Article: Seroprevalence of pandemic h1n1 antibody among health care workers in hong kong following receipt of monovalent 2009 h1n1 influenza vaccine
| Title | Seroprevalence of pandemic h1n1 antibody among health care workers in hong kong following receipt of monovalent 2009 h1n1 influenza vaccine | ||||||||
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| Authors | Zhou, Y2 Ng, DMW2 Seto, WH1 Ip, DKM2 Kwok, HKH1 Ma, ESK2 Ng, S2 Lau, LLH2 Peiris, JSM2 3 Cowling, BJ2 | ||||||||
| Keywords | Influenza virus A H1N1 Seroprevalence 2009 H1N1 influenza Antibody titer Immunogenicity | ||||||||
| Issue Date | 2011 | ||||||||
| Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | ||||||||
| Citation | Plos One, 2011, v. 6 n. 11 [How to Cite?] DOI: http://dx.doi.org/10.1371/journal.pone.0027169 | ||||||||
| Abstract | Background: Healthcare workers in many countries are recommended to receive influenza vaccine to protect themselves as well as patients. A monovalent H1N1 vaccine became available in Hong Kong in December 2009 and around 10% of local healthcare workers had received the vaccine by February 2010. Methods: We conducted a cross-sectional study of the prevalence of antibody to pandemic (H1N1) 2009 among HCWs in Hong Kong in February-March 2010 following the first pandemic wave and the pH1N1 vaccination campaign. In this study we focus on the subset of healthcare workers who reported receipt of non-adjuvanted monovalent 2009 H1N1 vaccine (Panenza, Sanofi Pasteur). Sera collected from HCWs were tested for antibody against the pH1N1 virus by hemagglutination inhibition (HI) and viral neutralization (VN) assays. Results: We enrolled 703 HCWs. Among 104 HCWs who reported receipt of pH1N1 vaccine, 54% (95% confidence interval (CI): 44%-63%) had antibody titer ≥1:40 by HI and 42% (95% CI: 33%-52%) had antibody titer ≥1:40 by VN. The proportion of HCWs with antibody titer ≥1:40 by HI and VN significantly decreased with age, and the proportion with antibody titer ≥1:40 by VN was marginally significantly lower among HCWs who reported prior receipt of 2007-08 seasonal influenza vaccine (odds ratio: 0.43; 95% CI: 0.19-1.00). After adjustment for age, the effect of prior seasonal vaccine receipt was not statistically significant. Conclusions: Our findings suggest that monovalent H1N1 vaccine may have had suboptimal immunogenicity in HCWs in Hong Kong. Larger studies are required to confirm whether influenza vaccine maintains high efficacy and effectiveness in HCWs. © 2011 Zhou et al. | ||||||||
| ISSN | 1932-6203 2011 Impact Factor: 4.092 2011 SCImago Journal Rankings: 0.519 | ||||||||
| DOI | http://dx.doi.org/10.1371/journal.pone.0027169 | ||||||||
| ISI Accession Number ID | WOS:000297348800017
Funding Information: This work has received financial support from the Area of Excellence Scheme of the Hong Kong University Grants Committee (grant no. AoE/M-12/06). The funding body was not involved in the collection, analysis, and interpretation of data, the writing of the article, or the decision to submit it for publication. | ||||||||
| PubMed Central ID | PMC3213124 | ||||||||
| References | References in Scopus | ||||||||
| Grants | Control of Pandemic and Inter-pandemic Influenza |
| dc.contributor.author | Zhou, Y | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Ng, DMW | ||||||||
| dc.contributor.author | Seto, WH | ||||||||
| dc.contributor.author | Ip, DKM | ||||||||
| dc.contributor.author | Kwok, HKH | ||||||||
| dc.contributor.author | Ma, ESK | ||||||||
| dc.contributor.author | Ng, S | ||||||||
| dc.contributor.author | Lau, LLH | ||||||||
| dc.contributor.author | Peiris, JSM | ||||||||
| dc.contributor.author | Cowling, BJ | ||||||||
| dc.date.accessioned | 2011-12-21T08:54:26Z | ||||||||
| dc.date.available | 2011-12-21T08:54:26Z | ||||||||
| dc.date.issued | 2011 | ||||||||
| dc.description.abstract | Background: Healthcare workers in many countries are recommended to receive influenza vaccine to protect themselves as well as patients. A monovalent H1N1 vaccine became available in Hong Kong in December 2009 and around 10% of local healthcare workers had received the vaccine by February 2010. Methods: We conducted a cross-sectional study of the prevalence of antibody to pandemic (H1N1) 2009 among HCWs in Hong Kong in February-March 2010 following the first pandemic wave and the pH1N1 vaccination campaign. In this study we focus on the subset of healthcare workers who reported receipt of non-adjuvanted monovalent 2009 H1N1 vaccine (Panenza, Sanofi Pasteur). Sera collected from HCWs were tested for antibody against the pH1N1 virus by hemagglutination inhibition (HI) and viral neutralization (VN) assays. Results: We enrolled 703 HCWs. Among 104 HCWs who reported receipt of pH1N1 vaccine, 54% (95% confidence interval (CI): 44%-63%) had antibody titer ≥1:40 by HI and 42% (95% CI: 33%-52%) had antibody titer ≥1:40 by VN. The proportion of HCWs with antibody titer ≥1:40 by HI and VN significantly decreased with age, and the proportion with antibody titer ≥1:40 by VN was marginally significantly lower among HCWs who reported prior receipt of 2007-08 seasonal influenza vaccine (odds ratio: 0.43; 95% CI: 0.19-1.00). After adjustment for age, the effect of prior seasonal vaccine receipt was not statistically significant. Conclusions: Our findings suggest that monovalent H1N1 vaccine may have had suboptimal immunogenicity in HCWs in Hong Kong. Larger studies are required to confirm whether influenza vaccine maintains high efficacy and effectiveness in HCWs. © 2011 Zhou et al. | ||||||||
| dc.description.grant | Control of Pandemic and Inter-pandemic Influenza | ||||||||
| dc.description.grantcode | 97655 | ||||||||
| dc.description.nature | published_or_final_version | ||||||||
| dc.identifier.citation | Plos One, 2011, v. 6 n. 11 [How to Cite?] DOI: http://dx.doi.org/10.1371/journal.pone.0027169 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0027169 | ||||||||
| dc.identifier.epage | e27169 | ||||||||
| dc.identifier.hkuros | 197999 | ||||||||
| dc.identifier.isi | WOS:000297348800017
Funding Information: This work has received financial support from the Area of Excellence Scheme of the Hong Kong University Grants Committee (grant no. AoE/M-12/06). The funding body was not involved in the collection, analysis, and interpretation of data, the writing of the article, or the decision to submit it for publication. | ||||||||
| dc.identifier.issn | 1932-6203 2011 Impact Factor: 4.092 2011 SCImago Journal Rankings: 0.519 | ||||||||
| dc.identifier.issue | 11 | ||||||||
| dc.identifier.pmcid | PMC3213124 | ||||||||
| dc.identifier.pmid | 22102878 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-80755159561 | ||||||||
| dc.identifier.spage | e27169 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/143772 | ||||||||
| dc.identifier.volume | 6 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | ||||||||
| dc.publisher.place | United States | ||||||||
| dc.relation.ispartof | PLoS ONE | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License | ||||||||
| dc.subject | Influenza virus A H1N1 | ||||||||
| dc.subject | Seroprevalence | ||||||||
| dc.subject | 2009 H1N1 influenza | ||||||||
| dc.subject | Antibody titer | ||||||||
| dc.subject | Immunogenicity | ||||||||
| dc.title | Seroprevalence of pandemic h1n1 antibody among health care workers in hong kong following receipt of monovalent 2009 h1n1 influenza vaccine | ||||||||
| dc.type | Article |
Author Affiliations
- Hong Kong Hospital Authority
- The University of Hong Kong
- HKU-Pasteur Research Centre