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Article: Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: Findings from a 30-year survey

TitleLower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: Findings from a 30-year survey
Authors
KeywordsChinese
Migrants
Myeloma incidence
Issue Date2011
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 2011, v. 52 n. 12, p. 2316-2320 How to Cite?
AbstractThe etiology of plasma cell myeloma (PCM) is largely unknown. Its incidence varies widely in different ethnic groups. Migrant study may help determine the relative contributions of genetic versus environmental factors to PCM pathogenesis. We performed a retrospective review of the computerized records of all patients diagnosed with PCM between 1975 and 2004 in British Columbia (BC), and identified patients of Chinese ethnicity. This was compared with PCM incidence in Hong Kong (HK) Chinese. Age distributions of HK, BC and BC Chinese populations were obtained from the census departments to calculate world age-standardized rates (WASRs). The WASR of PCM over the 30-year period in BC Chinese was 1.64/100 000 person-years (95% confidence interval [CI] 1.371.93). This was similar to the WASR observed in HK (1.78, 95% CI 1.731.83), with a standardized incidence ratio (SIR) of 0.91 (95% CI 0.741.10). The rate was much lower than that in the BC non-Chinese background population (WASR 3.59, 95% CI 3.503.68; SIR 0.46, 95% CI 0.380.56). The lower rates in BC Chinese were maintained across all years, both genders and in all age groups above 45 years. Our observations suggest a strong genetic component as the cause of differences in the ethnic predisposition to PCM. © 2011 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/143770
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_HK
dc.contributor.authorSong, Ken_HK
dc.contributor.authorMang, Oen_HK
dc.contributor.authorIp, DKMen_HK
dc.contributor.authorAu, WYen_HK
dc.date.accessioned2011-12-21T08:54:16Z-
dc.date.available2011-12-21T08:54:16Z-
dc.date.issued2011en_HK
dc.identifier.citationLeukemia And Lymphoma, 2011, v. 52 n. 12, p. 2316-2320en_HK
dc.identifier.issn1042-8194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143770-
dc.description.abstractThe etiology of plasma cell myeloma (PCM) is largely unknown. Its incidence varies widely in different ethnic groups. Migrant study may help determine the relative contributions of genetic versus environmental factors to PCM pathogenesis. We performed a retrospective review of the computerized records of all patients diagnosed with PCM between 1975 and 2004 in British Columbia (BC), and identified patients of Chinese ethnicity. This was compared with PCM incidence in Hong Kong (HK) Chinese. Age distributions of HK, BC and BC Chinese populations were obtained from the census departments to calculate world age-standardized rates (WASRs). The WASR of PCM over the 30-year period in BC Chinese was 1.64/100 000 person-years (95% confidence interval [CI] 1.371.93). This was similar to the WASR observed in HK (1.78, 95% CI 1.731.83), with a standardized incidence ratio (SIR) of 0.91 (95% CI 0.741.10). The rate was much lower than that in the BC non-Chinese background population (WASR 3.59, 95% CI 3.503.68; SIR 0.46, 95% CI 0.380.56). The lower rates in BC Chinese were maintained across all years, both genders and in all age groups above 45 years. Our observations suggest a strong genetic component as the cause of differences in the ethnic predisposition to PCM. © 2011 Informa UK, Ltd.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_HK
dc.relation.ispartofLeukemia and Lymphomaen_HK
dc.subjectChineseen_HK
dc.subjectMigrantsen_HK
dc.subjectMyeloma incidenceen_HK
dc.titleLower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: Findings from a 30-year surveyen_HK
dc.typeArticleen_HK
dc.identifier.emailIp, DKM:dkmip@hku.hken_HK
dc.identifier.authorityIp, DKM=rp00256en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3109/10428194.2011.601475en_HK
dc.identifier.pmid21851219-
dc.identifier.scopuseid_2-s2.0-82255193015en_HK
dc.identifier.hkuros198042en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-82255193015&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2316en_HK
dc.identifier.epage2320en_HK
dc.identifier.isiWOS:000297700900017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, V=54782412600en_HK
dc.identifier.scopusauthoridSong, K=8737393700en_HK
dc.identifier.scopusauthoridMang, O=6603963663en_HK
dc.identifier.scopusauthoridIp, DKM=35117701600en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK

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