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Article: Reversible posterior leukoencephalopathy syndrome in Chinese children induced by chemotherapy: A review of five cases

TitleReversible posterior leukoencephalopathy syndrome in Chinese children induced by chemotherapy: A review of five cases
Authors
KeywordsAntineoplastic combined chemotherapy protocols
Child
Magnetic resonance imaging
Posterior leukoencephalopathy syndrome
Seizures
Issue Date2011
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 2011, v. 17 n. 1, p. 61-66 How to Cite?
AbstractThis is a retrospective review of the clinico-radiological features and neurological outcomes of reversible posterior leukoencephalopathy syndrome episodes in Chinese cancer children receiving chemotherapy in a regional hospital in Hong Kong from 1998 to 2008. Five children (3 males and 2 females) with a mean age of 7 years were identified, four of whom had acute lymphoblastic leukaemia and one had a central nervous system germ cell tumour. Presenting symptoms included seizures (100%), altered mental function (100%), headache (40%), and visual disturbance (60%). The mean systolic blood pressure at presentation was 158 mm Hg. Approximately 80% had typical radiological features of reversible posterior leukoencephalopathy syndrome. All showed complete recovery after the acute stage, but one subsequently developed epilepsy. Two patients ultimately died of refractory malignant disease. Two others were followed up for a mean of 6 years, and remained neurologically normal. This report was the first case review documenting reversible posterior leukoencephalopathy syndrome in Chinese cancer children. The clinico-radiological features and neurological outcomes were similar to those reported in western series. Early recognition of the syndrome is important to facilitate appropriate treatment. The central nervous system damage may not be reversible and thus long-term follow-up is warranted.
Persistent Identifierhttp://hdl.handle.net/10722/143753
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279
References

 

DC FieldValueLanguage
dc.contributor.authorBelaramani, KMen_HK
dc.contributor.authorLai, Ven_HK
dc.contributor.authorLi, CHen_HK
dc.contributor.authorLee, ACWen_HK
dc.contributor.authorKwong, NSen_HK
dc.date.accessioned2011-12-21T08:53:31Z-
dc.date.available2011-12-21T08:53:31Z-
dc.date.issued2011en_HK
dc.identifier.citationHong Kong Medical Journal, 2011, v. 17 n. 1, p. 61-66en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143753-
dc.description.abstractThis is a retrospective review of the clinico-radiological features and neurological outcomes of reversible posterior leukoencephalopathy syndrome episodes in Chinese cancer children receiving chemotherapy in a regional hospital in Hong Kong from 1998 to 2008. Five children (3 males and 2 females) with a mean age of 7 years were identified, four of whom had acute lymphoblastic leukaemia and one had a central nervous system germ cell tumour. Presenting symptoms included seizures (100%), altered mental function (100%), headache (40%), and visual disturbance (60%). The mean systolic blood pressure at presentation was 158 mm Hg. Approximately 80% had typical radiological features of reversible posterior leukoencephalopathy syndrome. All showed complete recovery after the acute stage, but one subsequently developed epilepsy. Two patients ultimately died of refractory malignant disease. Two others were followed up for a mean of 6 years, and remained neurologically normal. This report was the first case review documenting reversible posterior leukoencephalopathy syndrome in Chinese cancer children. The clinico-radiological features and neurological outcomes were similar to those reported in western series. Early recognition of the syndrome is important to facilitate appropriate treatment. The central nervous system damage may not be reversible and thus long-term follow-up is warranted.en_HK
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.subjectAntineoplastic combined chemotherapy protocolsen_HK
dc.subjectChilden_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subjectPosterior leukoencephalopathy syndromeen_HK
dc.subjectSeizuresen_HK
dc.subject.meshAntineoplastic Agents - adverse effects-
dc.subject.meshChild, Preschool-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshPosterior Leukoencephalopathy Syndrome - chemically induced - pathology - radiography-
dc.subject.meshRetrospective Studies-
dc.titleReversible posterior leukoencephalopathy syndrome in Chinese children induced by chemotherapy: A review of five casesen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, V:laiv@hku.hken_HK
dc.identifier.authorityLai, V=rp01516en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.pmid21282828-
dc.identifier.scopuseid_2-s2.0-79951485894en_HK
dc.identifier.hkuros197947en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951485894&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue1en_HK
dc.identifier.spage61en_HK
dc.identifier.epage66en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridBelaramani, KM=36436886100en_HK
dc.identifier.scopusauthoridLai, V=15829844300en_HK
dc.identifier.scopusauthoridLi, CH=8354475100en_HK
dc.identifier.scopusauthoridLee, ACW=7405631431en_HK
dc.identifier.scopusauthoridKwong, NS=12646682000en_HK

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