File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
  • Basic View
  • Metadata View
  • XML View
TitleDownregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
 
AuthorsLi, Y2
Chen, L1
Nie, CJ2
Zeng, TT2
Liu, H2
Mao, X2
Qin, Y3
Zhu, YH2
Fu, L1
Guan, XY2 1
 
Issue Date2011
 
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
 
CitationCancer Research, 2011, v. 71 n. 19, p. 6106-6115 [How to Cite?]
DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-4291
 
AbstractDeletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease. ©2011 AACR.
 
ISSN0008-5472
2013 Impact Factor: 9.284
2013 SCImago Journal Rankings: 5.627
 
DOIhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4291
 
ISI Accession Number IDWOS:000295397700004
Funding AgencyGrant Number
National Natural Science Foundation of China30700820
30772475
30971606
Research Fund for the Doctoral Program of Higher Education of China20070558272
Sun Yat-Sen University85000-3171311
National Key Sci-Tech Special Project of China2008ZX10002-022
Hong Kong Research Grant Council Central AllocationHKUST 2/06C
Funding Information:

This work was supported by Grants from the National Natural Science Foundation of China (30700820, 30772475, and 30971606), Research Fund for the Doctoral Program of Higher Education of China (20070558272) and Sun Yat-Sen University "Hundred Talents Program" (85000-3171311), National Key Sci-Tech Special Project of China (2008ZX10002-022), Hong Kong Research Grant Council Central Allocation (HKUST 2/06C).

 
ReferencesReferences in Scopus
 
GrantsEsophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
 
DC FieldValue
dc.contributor.authorLi, Y
 
dc.contributor.authorChen, L
 
dc.contributor.authorNie, CJ
 
dc.contributor.authorZeng, TT
 
dc.contributor.authorLiu, H
 
dc.contributor.authorMao, X
 
dc.contributor.authorQin, Y
 
dc.contributor.authorZhu, YH
 
dc.contributor.authorFu, L
 
dc.contributor.authorGuan, XY
 
dc.date.accessioned2011-12-21T08:48:23Z
 
dc.date.available2011-12-21T08:48:23Z
 
dc.date.issued2011
 
dc.description.abstractDeletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease. ©2011 AACR.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCancer Research, 2011, v. 71 n. 19, p. 6106-6115 [How to Cite?]
DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-4291
 
dc.identifier.doihttp://dx.doi.org/10.1158/0008-5472.CAN-10-4291
 
dc.identifier.epage6115
 
dc.identifier.hkuros198004
 
dc.identifier.isiWOS:000295397700004
Funding AgencyGrant Number
National Natural Science Foundation of China30700820
30772475
30971606
Research Fund for the Doctoral Program of Higher Education of China20070558272
Sun Yat-Sen University85000-3171311
National Key Sci-Tech Special Project of China2008ZX10002-022
Hong Kong Research Grant Council Central AllocationHKUST 2/06C
Funding Information:

This work was supported by Grants from the National Natural Science Foundation of China (30700820, 30772475, and 30971606), Research Fund for the Doctoral Program of Higher Education of China (20070558272) and Sun Yat-Sen University "Hundred Talents Program" (85000-3171311), National Key Sci-Tech Special Project of China (2008ZX10002-022), Hong Kong Research Grant Council Central Allocation (HKUST 2/06C).

 
dc.identifier.issn0008-5472
2013 Impact Factor: 9.284
2013 SCImago Journal Rankings: 5.627
 
dc.identifier.issue19
 
dc.identifier.pmid21844183
 
dc.identifier.scopuseid_2-s2.0-80053349237
 
dc.identifier.spage6106
 
dc.identifier.urihttp://hdl.handle.net/10722/143746
 
dc.identifier.volume71
 
dc.languageeng
 
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer Research
 
dc.relation.projectEsophageal Carcinoma Research Center
 
dc.relation.projectEsophageal Carcinoma Research Center
 
dc.relation.projectEsophageal Carcinoma Research Center
 
dc.relation.projectEsophageal Carcinoma Research Center
 
dc.relation.projectEsophageal Carcinoma Research Center
 
dc.relation.projectEsophageal Carcinoma Research Center
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathology - physiopathology
 
dc.subject.meshCyclin-Dependent Kinase 4 - genetics
 
dc.subject.meshEsophageal Neoplasms - genetics - pathology - physiopathology
 
dc.subject.meshRNA-Binding Proteins - genetics
 
dc.subject.meshTrans-Activators - genetics
 
dc.titleDownregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Li, Y</contributor.author>
<contributor.author>Chen, L</contributor.author>
<contributor.author>Nie, CJ</contributor.author>
<contributor.author>Zeng, TT</contributor.author>
<contributor.author>Liu, H</contributor.author>
<contributor.author>Mao, X</contributor.author>
<contributor.author>Qin, Y</contributor.author>
<contributor.author>Zhu, YH</contributor.author>
<contributor.author>Fu, L</contributor.author>
<contributor.author>Guan, XY</contributor.author>
<date.accessioned>2011-12-21T08:48:23Z</date.accessioned>
<date.available>2011-12-21T08:48:23Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Cancer Research, 2011, v. 71 n. 19, p. 6106-6115</identifier.citation>
<identifier.issn>0008-5472</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/143746</identifier.uri>
<description.abstract>Deletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease. &#169;2011 AACR.</description.abstract>
<language>eng</language>
<publisher>American Association for Cancer Research. The Journal&apos;s web site is located at http://cancerres.aacrjournals.org/</publisher>
<relation.ispartof>Cancer Research</relation.ispartof>
<subject.mesh>Carcinoma, Squamous Cell - genetics - pathology - physiopathology</subject.mesh>
<subject.mesh>Cyclin-Dependent Kinase 4 - genetics</subject.mesh>
<subject.mesh>Esophageal Neoplasms - genetics - pathology - physiopathology</subject.mesh>
<subject.mesh>RNA-Binding Proteins - genetics</subject.mesh>
<subject.mesh>Trans-Activators - genetics</subject.mesh>
<title>Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1158/0008-5472.CAN-10-4291</identifier.doi>
<identifier.pmid>21844183</identifier.pmid>
<identifier.scopus>eid_2-s2.0-80053349237</identifier.scopus>
<identifier.hkuros>198004</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053349237&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>71</identifier.volume>
<identifier.issue>19</identifier.issue>
<identifier.spage>6106</identifier.spage>
<identifier.epage>6115</identifier.epage>
<identifier.isi>WOS:000295397700004</identifier.isi>
<publisher.place>United States</publisher.place>
<relation.project>Esophageal Carcinoma Research Center</relation.project>
<relation.project>Esophageal Carcinoma Research Center</relation.project>
<relation.project>Esophageal Carcinoma Research Center</relation.project>
<relation.project>Esophageal Carcinoma Research Center</relation.project>
<relation.project>Esophageal Carcinoma Research Center</relation.project>
<relation.project>Esophageal Carcinoma Research Center</relation.project>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University
  3. First Affiliated Hospital of Zhengzhou University