Article: Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma

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TitleDownregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
AuthorsLi, Y2
Chen, L1
Nie, CJ2
Zeng, TT2
Liu, H2
Mao, X2
Qin, Y3
Zhu, YH2
Fu, L1
Guan, XY1 2
Issue Date2011
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
CitationCancer Research, 2011, v. 71 n. 19, p. 6106-6115 [How to Cite?]
DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-4291
AbstractDeletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease. ©2011 AACR.
ISSN0008-5472
2011 Impact Factor: 7.856
2011 SCImago Journal Rankings: 1.309
DOIhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4291
ReferencesReferences in Scopus
GrantsEsophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
Esophageal Carcinoma Research Center
DC Field
Value
dc.contributor.authorLi, Y
dc.contributor.authorChen, L
dc.contributor.authorNie, CJ
dc.contributor.authorZeng, TT
dc.contributor.authorLiu, H
dc.contributor.authorMao, X
dc.contributor.authorQin, Y
dc.contributor.authorZhu, YH
dc.contributor.authorFu, L
dc.contributor.authorGuan, XY
dc.date.accessioned2011-12-21T08:48:23Z
dc.date.available2011-12-21T08:48:23Z
dc.date.issued2011
dc.description.abstractDeletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease. ©2011 AACR.
dc.description.grantEsophageal Carcinoma Research Center
dc.description.grantEsophageal Carcinoma Research Center
dc.description.grantEsophageal Carcinoma Research Center
dc.description.grantEsophageal Carcinoma Research Center
dc.description.grantEsophageal Carcinoma Research Center
dc.description.grantEsophageal Carcinoma Research Center
dc.description.grantcode96288
dc.description.grantcode96290
dc.description.grantcode96289
dc.description.grantcode96293
dc.description.grantcode96292
dc.description.grantcode96291
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer Research, 2011, v. 71 n. 19, p. 6106-6115 [How to Cite?]
DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-4291
dc.identifier.doihttp://dx.doi.org/10.1158/0008-5472.CAN-10-4291
dc.identifier.epage6115
dc.identifier.hkuros198004
dc.identifier.isiWOS:000295397700004
Funding AgencyGrant Number
National Natural Science Foundation of China30700820
30772475
30971606
Research Fund for the Doctoral Program of Higher Education of China20070558272
Sun Yat-Sen University85000-3171311
National Key Sci-Tech Special Project of China2008ZX10002-022
Hong Kong Research Grant Council Central AllocationHKUST 2/06C
Funding Information:

This work was supported by Grants from the National Natural Science Foundation of China (30700820, 30772475, and 30971606), Research Fund for the Doctoral Program of Higher Education of China (20070558272) and Sun Yat-Sen University "Hundred Talents Program" (85000-3171311), National Key Sci-Tech Special Project of China (2008ZX10002-022), Hong Kong Research Grant Council Central Allocation (HKUST 2/06C).

dc.identifier.issn0008-5472
2011 Impact Factor: 7.856
2011 SCImago Journal Rankings: 1.309
dc.identifier.issue19
dc.identifier.pmid21844183
dc.identifier.scopuseid_2-s2.0-80053349237
dc.identifier.spage6106
dc.identifier.urihttp://hdl.handle.net/10722/143746
dc.identifier.volume71
dc.languageeng
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
dc.publisher.placeUnited States
dc.relation.ispartofCancer Research
dc.relation.referencesReferences in Scopus
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathology - physiopathology
dc.subject.meshCyclin-Dependent Kinase 4 - genetics
dc.subject.meshEsophageal Neoplasms - genetics - pathology - physiopathology
dc.subject.meshRNA-Binding Proteins - genetics
dc.subject.meshTrans-Activators - genetics
dc.titleDownregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Sun Yat-Sen University
  3. First Affiliated Hospital of Zhengzhou University