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Article: Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma

TitleDownregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma
Authors
Issue Date2011
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2011, v. 71 n. 19, p. 6106-6115 How to Cite?
AbstractDeletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease. ©2011 AACR.
Persistent Identifierhttp://hdl.handle.net/10722/143746
ISSN
2014 Impact Factor: 9.329
2013 SCImago Journal Rankings: 5.627
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30700820
30772475
30971606
Research Fund for the Doctoral Program of Higher Education of China20070558272
Sun Yat-Sen University85000-3171311
National Key Sci-Tech Special Project of China2008ZX10002-022
Hong Kong Research Grant Council Central AllocationHKUST 2/06C
Funding Information:

This work was supported by Grants from the National Natural Science Foundation of China (30700820, 30772475, and 30971606), Research Fund for the Doctoral Program of Higher Education of China (20070558272) and Sun Yat-Sen University "Hundred Talents Program" (85000-3171311), National Key Sci-Tech Special Project of China (2008ZX10002-022), Hong Kong Research Grant Council Central Allocation (HKUST 2/06C).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorNie, CJen_HK
dc.contributor.authorZeng, TTen_HK
dc.contributor.authorLiu, Hen_HK
dc.contributor.authorMao, Xen_HK
dc.contributor.authorQin, Yen_HK
dc.contributor.authorZhu, YHen_HK
dc.contributor.authorFu, Len_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2011-12-21T08:48:23Z-
dc.date.available2011-12-21T08:48:23Z-
dc.date.issued2011en_HK
dc.identifier.citationCancer Research, 2011, v. 71 n. 19, p. 6106-6115en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143746-
dc.description.abstractDeletions on chromosome 3p occur often in many solid tumors, including esophageal squamous cell carcinoma (ESCC), suggesting the existence at this location of one or more tumor suppressor genes (TSG). In this study, we characterized RBMS3 gene encoding an RNA-binding protein as a candidate TSG located at 3p24. Downregulation of RBMS3 mRNA and protein levels was documented in approximately 50% of the primary ESCCs examined. Clinical association studies determined that RBMS3 downregulation was associated with poor clinical outcomes. RBMS3 expression effectively suppressed the tumorigenicity of ESCC cells in vitro and in vivo, including by inhibition of cell growth rate, foci formation, soft agar colony formation, and tumor formation in nude mice. Molecular analyses revealed that RBMS3 downregulated c-Myc and CDK4, leading to subsequent inhibition of Rb phosphorylation. Together, our findings suggest a tumor suppression function for the human RBMS3 gene in ESCC, acting through c-Myc downregulation, with genetic loss of this gene in ESCC contributing to poor outcomes in this deadly disease. ©2011 AACR.en_HK
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - pathology - physiopathology-
dc.subject.meshCyclin-Dependent Kinase 4 - genetics-
dc.subject.meshEsophageal Neoplasms - genetics - pathology - physiopathology-
dc.subject.meshRNA-Binding Proteins - genetics-
dc.subject.meshTrans-Activators - genetics-
dc.titleDownregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailFu, L:gracefu@graduate.hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityFu, L=rp01435en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1158/0008-5472.CAN-10-4291en_HK
dc.identifier.pmid21844183en_HK
dc.identifier.scopuseid_2-s2.0-80053349237en_HK
dc.identifier.hkuros198004en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053349237&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume71en_HK
dc.identifier.issue19en_HK
dc.identifier.spage6106en_HK
dc.identifier.epage6115en_HK
dc.identifier.isiWOS:000295397700004-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectEsophageal Carcinoma Research Center-
dc.relation.projectEsophageal Carcinoma Research Center-
dc.relation.projectEsophageal Carcinoma Research Center-
dc.relation.projectEsophageal Carcinoma Research Center-
dc.relation.projectEsophageal Carcinoma Research Center-
dc.relation.projectEsophageal Carcinoma Research Center-
dc.identifier.scopusauthoridLi, Y=36079617800en_HK
dc.identifier.scopusauthoridChen, L=23569135400en_HK
dc.identifier.scopusauthoridNie, CJ=36463961500en_HK
dc.identifier.scopusauthoridZeng, TT=37015099200en_HK
dc.identifier.scopusauthoridLiu, H=27171509500en_HK
dc.identifier.scopusauthoridMao, X=7402841436en_HK
dc.identifier.scopusauthoridQin, Y=7403100680en_HK
dc.identifier.scopusauthoridZhu, YH=19338197800en_HK
dc.identifier.scopusauthoridFu, L=22979236700en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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