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Article: Establishment and characterization of human non-small cell lung cancer cell lines

TitleEstablishment and characterization of human non-small cell lung cancer cell lines
Authors
Issue Date2012
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/mmr/
Citation
Molecular Medicine Reports, 2012, v. 5 n. 1, p. 114-117 How to Cite?
AbstractNon-small cell lung cancer (NSCLC), a highly malignant tumor, is common in China and is associated with a very poor 5-year survival rate. To better understand the cancer biology of this disease, we report here the establishment of three new NSCLC cell lines, SCC210011, SCC211441 and ACC212102, from the tumor tissue of three NSCLC patients. By histological analysis, we found that all three cell lines displayed the typical features of endothelial cancer cells. The population doubling times of SCC210011, SCC211441 and ACC212102 cells were 42, 38 and 25 h, respectively. Our cytogenetic studies indicated that these cell lines exhibit structural and numerical chromosomal abnormalities. Furthermore, the tumorigenicity in nude mice was confirmed, and H&E staining results revealed that they resembled the primary tissue. These newly established cell lines may serve as useful models for studying the molecular pathogenesis of NSCLC.
Persistent Identifierhttp://hdl.handle.net/10722/143745
ISSN
2015 Impact Factor: 1.559
2015 SCImago Journal Rankings: 0.637
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30772475
30700820
30971606
Sun Yat-Sen University85000-3171311
Nation Key Sci-Tech Special Project of China2008ZX10002-022
Funding Information:

This study was supported in part by grants from the National Natural Science Foundation of China (30772475, 30700820 and 30971606), the Sun Yat-Sen University 'Hundred Talents Program' (85000-3171311), and the Nation Key Sci-Tech Special Project of China (2008ZX10002-022).

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Jen_HK
dc.contributor.authorYang, Hen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorZhu, Yen_HK
dc.contributor.authorDai, Yen_HK
dc.contributor.authorChen, Ken_HK
dc.contributor.authorAi, Jen_HK
dc.contributor.authorZeng, Ten_HK
dc.contributor.authorMao, Xen_HK
dc.contributor.authorLiu, Len_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorGuan, XYen_HK
dc.date.accessioned2011-12-21T08:48:21Z-
dc.date.available2011-12-21T08:48:21Z-
dc.date.issued2012en_HK
dc.identifier.citationMolecular Medicine Reports, 2012, v. 5 n. 1, p. 114-117en_HK
dc.identifier.issn1791-2997en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143745-
dc.description.abstractNon-small cell lung cancer (NSCLC), a highly malignant tumor, is common in China and is associated with a very poor 5-year survival rate. To better understand the cancer biology of this disease, we report here the establishment of three new NSCLC cell lines, SCC210011, SCC211441 and ACC212102, from the tumor tissue of three NSCLC patients. By histological analysis, we found that all three cell lines displayed the typical features of endothelial cancer cells. The population doubling times of SCC210011, SCC211441 and ACC212102 cells were 42, 38 and 25 h, respectively. Our cytogenetic studies indicated that these cell lines exhibit structural and numerical chromosomal abnormalities. Furthermore, the tumorigenicity in nude mice was confirmed, and H&E staining results revealed that they resembled the primary tissue. These newly established cell lines may serve as useful models for studying the molecular pathogenesis of NSCLC.en_HK
dc.languageengen_US
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/mmr/-
dc.relation.ispartofMolecular Medicine Reportsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - genetics - pathologyen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLung Neoplasms - genetics - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Nudeen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNeoplasm Transplantationen_HK
dc.subject.meshTransplantation, Heterologousen_HK
dc.subject.meshTumor Cells, Cultureden_HK
dc.titleEstablishment and characterization of human non-small cell lung cancer cell linesen_HK
dc.typeArticleen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3892/mmr.2011.613en_HK
dc.identifier.pmid21971914-
dc.identifier.scopuseid_2-s2.0-84855238397en_HK
dc.identifier.hkuros198001en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855238397&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue1en_HK
dc.identifier.spage114en_HK
dc.identifier.epage117en_HK
dc.identifier.isiWOS:000297486700021-
dc.publisher.placeGreece-
dc.identifier.scopusauthoridLi, J=54881130300en_HK
dc.identifier.scopusauthoridYang, H=54881171200en_HK
dc.identifier.scopusauthoridChen, L=23569135400en_HK
dc.identifier.scopusauthoridLi, Y=36078636500en_HK
dc.identifier.scopusauthoridZhu, Y=19338197800en_HK
dc.identifier.scopusauthoridDai, Y=37014328400en_HK
dc.identifier.scopusauthoridChen, K=54881178400en_HK
dc.identifier.scopusauthoridAi, J=54881072600en_HK
dc.identifier.scopusauthoridZeng, T=37015099200en_HK
dc.identifier.scopusauthoridMao, X=7402841436en_HK
dc.identifier.scopusauthoridLiu, L=54881133800en_HK
dc.identifier.scopusauthoridLi, X=54880729200en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK

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