File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of inner retinal dysfunction on slow double-stimulation multifocal electroretinogram

TitleEffect of inner retinal dysfunction on slow double-stimulation multifocal electroretinogram
Authors
Issue Date2011
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal of Ophthalmology, 2011, v. 95 n. 11, p. 1597-1602 How to Cite?
AbstractPURPOSE: This study investigated the retinal adaptive mechanism in inner retinal dysfunction using the slow double-stimulation multifocal electroretinogram (mfERG) paradigm. METHODS: Slow double-stimulation mfERG responses were recorded from 15 eyes of 15 4-month-old Mongolian gerbils in control conditions and after suppression of inner retinal responses with injections of tetrodotoxin (TTX) and N-methyl-d-aspartic acid (NMDA). The stimulation consisted of five video frames: the two initial frames with multifocal flashes were triggered by two independent m-sequences, followed by three dark video frames. The results were compared with findings in humans: 7 subjects with glaucoma and 31 age-matched normal subjects were measured using the same mfERG protocol. RESULTS: The stimulation generates two responses (M(1) and M(2)) from the two independent multifocal frames. The M(1):M(2) ratio showed a significant reduction after administration of TTX+NMDA in the animal study. This matched with the human glaucoma findings. Glaucoma subjects generally have a reduced M(1):M(2) ratio; this ratio showed a sensitivity of 86%, with a specificity of 84% for differentiating normal eyes from glaucomatous eyes. CONCLUSION: This stimulation paradigm provides a method of measuring temporal visual characteristics. The M(1):M(2) ratio acts as an indirect functional indicator of retinal adaptation, which may be abnormal in the diseased retina. Further development of this method may help to describe the functional variation in the diseased retina and to predict the occurrence of a range of retinopathies.
Persistent Identifierhttp://hdl.handle.net/10722/143733
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
ISI Accession Number ID
Funding AgencyGrant Number
Departmental General Research FundGU585
GU858
Grants for Post-Doctoral FellowshipG-YX3C
Hong Kong Polytechnic UniversityJ-BB76
Funding Information:

This study was supported by the Departmental General Research Fund (GU585, GU858), the Grants for Post-Doctoral Fellowship (G-YX3C) and the Niche Areas Glaucoma Research (J-BB76) from The Hong Kong Polytechnic University.

References

 

DC FieldValueLanguage
dc.contributor.authorChu, PHWen_HK
dc.contributor.authorNg, YFen_HK
dc.contributor.authorTing, PWKen_HK
dc.contributor.authorLung, JCYen_HK
dc.contributor.authorHo, WCen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorTo, CHen_HK
dc.contributor.authorChan, HHLen_HK
dc.date.accessioned2011-12-21T08:47:37Z-
dc.date.available2011-12-21T08:47:37Z-
dc.date.issued2011en_HK
dc.identifier.citationBritish Journal of Ophthalmology, 2011, v. 95 n. 11, p. 1597-1602en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143733-
dc.description.abstractPURPOSE: This study investigated the retinal adaptive mechanism in inner retinal dysfunction using the slow double-stimulation multifocal electroretinogram (mfERG) paradigm. METHODS: Slow double-stimulation mfERG responses were recorded from 15 eyes of 15 4-month-old Mongolian gerbils in control conditions and after suppression of inner retinal responses with injections of tetrodotoxin (TTX) and N-methyl-d-aspartic acid (NMDA). The stimulation consisted of five video frames: the two initial frames with multifocal flashes were triggered by two independent m-sequences, followed by three dark video frames. The results were compared with findings in humans: 7 subjects with glaucoma and 31 age-matched normal subjects were measured using the same mfERG protocol. RESULTS: The stimulation generates two responses (M(1) and M(2)) from the two independent multifocal frames. The M(1):M(2) ratio showed a significant reduction after administration of TTX+NMDA in the animal study. This matched with the human glaucoma findings. Glaucoma subjects generally have a reduced M(1):M(2) ratio; this ratio showed a sensitivity of 86%, with a specificity of 84% for differentiating normal eyes from glaucomatous eyes. CONCLUSION: This stimulation paradigm provides a method of measuring temporal visual characteristics. The M(1):M(2) ratio acts as an indirect functional indicator of retinal adaptation, which may be abnormal in the diseased retina. Further development of this method may help to describe the functional variation in the diseased retina and to predict the occurrence of a range of retinopathies.en_HK
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.rightsBritish Journal of Ophthalmology. Copyright © BMJ Publishing Group.-
dc.rightsThe following statements must accompany the articles posted on the Contributor(s)’s and/or his/her institution’s website: Locked and research funded articles acknowledgement: This article has been accepted for publication in [Contributor, please insert journal name]. The definitive copyedited, typeset version [Contributor please insert complete citation information when available] is available online at: www. [Contributor please insert as applicable] .com Unlocked article acknowledgement: This article has been accepted for publication in [Contributor please insert full citation] following peer review and can also be viewed on the journal’s website at www. [Contributor please insert as applicable] .com-
dc.subject.meshAdaptation, Physiological - physiologyen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshElectroretinography - methodsen_HK
dc.subject.meshGlaucoma, Open-Angle - complications - diagnosis - physiopathologyen_HK
dc.subject.meshRetinal Diseases - diagnosis - etiology - physiopathologyen_HK
dc.titleEffect of inner retinal dysfunction on slow double-stimulation multifocal electroretinogramen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.emailChan, HHL: henryhl.chan@polyu.edu.hk-
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/bjophthalmol-2011-300263en_HK
dc.identifier.pmid21849350-
dc.identifier.scopuseid_2-s2.0-80054938549en_HK
dc.identifier.hkuros197908en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054938549&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1597en_HK
dc.identifier.epage1602en_HK
dc.identifier.isiWOS:000296233900026-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, HHL=24774420300en_HK
dc.identifier.scopusauthoridTo, CH=34881125500en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridHo, WC=36945655400en_HK
dc.identifier.scopusauthoridLung, JCY=24385392700en_HK
dc.identifier.scopusauthoridTing, PWK=7006341219en_HK
dc.identifier.scopusauthoridNg, YF=23989024100en_HK
dc.identifier.scopusauthoridChu, PHW=9243174200en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats