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Article: The search for the cystic fibrosis gene

TitleThe search for the cystic fibrosis gene
Authors
Buchwald, MTsui, LCRiordan, JR
Issue Date1989
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
American Journal Of Physiology - Lung Cellular And Molecular Physiology, 1989, v. 257 n. 2, p. 1/1 How to Cite?
AbstractThis article reviews progress made to date in the attempt to find the gene causing cystic fibrosis (CF). The search has been focused on a region of the human genome containing no more than 10 genes and has been accomplished in two steps. First, linkage analysis was used to localize the gene to the q31 band of chromosome 7. Subsequently, molecular cloning methods were employed to isolate DNA segments estimated to be within 400,000 base pairs of the CF gene. The current challenge in the research is to find the genes located in this interval and to then prove that one of them is the CF gene. The approaches by which this will be accomplished are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/143712
ISSN
0002-9513
ISI Accession Number ID
WOS:A1989AL12600081

 

DC FieldValueLanguage
dc.contributor.authorBuchwald, Men_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorRiordan, JRen_HK
dc.date.accessioned2011-12-16T08:42:24Z-
dc.date.available2011-12-16T08:42:24Z-
dc.date.issued1989en_HK
dc.identifier.citationAmerican Journal Of Physiology - Lung Cellular And Molecular Physiology, 1989, v. 257 n. 2, p. 1/1en_HK
dc.identifier.issn0002-9513en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143712-
dc.description.abstractThis article reviews progress made to date in the attempt to find the gene causing cystic fibrosis (CF). The search has been focused on a region of the human genome containing no more than 10 genes and has been accomplished in two steps. First, linkage analysis was used to localize the gene to the q31 band of chromosome 7. Subsequently, molecular cloning methods were employed to isolate DNA segments estimated to be within 400,000 base pairs of the CF gene. The current challenge in the research is to find the genes located in this interval and to then prove that one of them is the CF gene. The approaches by which this will be accomplished are discussed.en_HK
dc.languageeng-
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_HK
dc.relation.ispartofAmerican Journal of Physiology - Lung Cellular and Molecular Physiologyen_HK
dc.rightsAmerican Journal of Physiology: Lung Cellular and Molecular Physiology. Copyright © American Physiological Society.-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Human, Pair 7-
dc.subject.meshCloning, Molecular-
dc.subject.meshCystic Fibrosis - genetics-
dc.subject.meshGenes-
dc.titleThe search for the cystic fibrosis geneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1040-0605&volume=257&issue=2&spage=L47&epage=L52&date=1989&atitle=The+search+for+the+cystic+fibrosis+gene-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid2669523-
dc.identifier.scopuseid_2-s2.0-0024424115en_HK
dc.identifier.volume257en_HK
dc.identifier.issue2en_HK
dc.identifier.spage1/1en_HK
dc.identifier.epage1/1en_HK
dc.identifier.isiWOS:A1989AL12600081-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBuchwald, M=7006759922en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridRiordan, JR=7202229758en_HK
dc.identifier.issnl0002-9513-

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