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Article: High-resolution mapping of quantitative trait loci in outbred mice

TitleHigh-resolution mapping of quantitative trait loci in outbred mice
Authors
Issue Date1999
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 1999, v. 21 n. 3, p. 305-308 How to Cite?
AbstractScreening the whole genome of a cross between two inbred animal strains has proved to be a powerful method for detecting genetic loci underlying quantitative behavioural traits, but the level of resolution offered by quantitative trait loci (QTL) mapping is still too coarse to permit molecular cloning of the genetic determinants. To achieve high-resolution mapping, we used an outbred stock of mice for which the entire genealogy is known. The heterogeneous stock (HS) was established 30 years ago from an eight-way cross of C57BL/6, BALB/c, RIII, AKR, DBA/2, I, A/J and C3H inbred mouse strains. At the time of the experiment reported here, the HS mice were at generation 58, theoretically offering at least a 30-fold increase in resolution for QTL mapping compared with a backcross or an F2 intercross. Using the HS mice we have mapped a QTL influencing a psychological trait in mice to a 0.8-cM interval on chromosome 1. This method allows simultaneous fine mapping of multiple QTLs, as shown by our report of a second QTL on chromosome 12. The high resolution possible with this approach makes QTLs accessible to positional cloning.
Persistent Identifierhttp://hdl.handle.net/10722/143704
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTalbot, CJen_HK
dc.contributor.authorNicod, Aen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorFulker, DWen_HK
dc.contributor.authorCollins, ACen_HK
dc.contributor.authorFlint, Jen_HK
dc.date.accessioned2011-12-16T08:09:38Z-
dc.date.available2011-12-16T08:09:38Z-
dc.date.issued1999en_HK
dc.identifier.citationNature Genetics, 1999, v. 21 n. 3, p. 305-308en_HK
dc.identifier.issn1061-4036en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143704-
dc.description.abstractScreening the whole genome of a cross between two inbred animal strains has proved to be a powerful method for detecting genetic loci underlying quantitative behavioural traits, but the level of resolution offered by quantitative trait loci (QTL) mapping is still too coarse to permit molecular cloning of the genetic determinants. To achieve high-resolution mapping, we used an outbred stock of mice for which the entire genealogy is known. The heterogeneous stock (HS) was established 30 years ago from an eight-way cross of C57BL/6, BALB/c, RIII, AKR, DBA/2, I, A/J and C3H inbred mouse strains. At the time of the experiment reported here, the HS mice were at generation 58, theoretically offering at least a 30-fold increase in resolution for QTL mapping compared with a backcross or an F2 intercross. Using the HS mice we have mapped a QTL influencing a psychological trait in mice to a 0.8-cM interval on chromosome 1. This method allows simultaneous fine mapping of multiple QTLs, as shown by our report of a second QTL on chromosome 12. The high resolution possible with this approach makes QTLs accessible to positional cloning.en_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_HK
dc.relation.ispartofNature Geneticsen_HK
dc.titleHigh-resolution mapping of quantitative trait loci in outbred miceen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/6825en_HK
dc.identifier.pmid10080185-
dc.identifier.scopuseid_2-s2.0-0032979854en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032979854&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue3en_HK
dc.identifier.spage305en_HK
dc.identifier.epage308en_HK
dc.identifier.isiWOS:000078977900026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTalbot, CJ=35093501800en_HK
dc.identifier.scopusauthoridNicod, A=6602219867en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridFulker, DW=7005792286en_HK
dc.identifier.scopusauthoridCollins, AC=7403186328en_HK
dc.identifier.scopusauthoridFlint, J=7102999294en_HK

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