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Article: The familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuse

TitleThe familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuse
Authors
Keywordsadolescence
alcohol abuse
antisocial behavior
comorbidity
depression
family study
Issue Date1997
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1997, v. 74 n. 2, p. 183-191 How to Cite?
AbstractThis study describes results from an ongoing family study of adolescent boys and their families designed to investigate potential risk factors for substance abuse. The adolescent treatment probands have severe drug and alcohol related problems and were recruited through a residential rehabilitation program. To date, the sample includes 251 individuals: 39 male probands and their families and 34 control families matched for age and geographic location (zip code). Probands and participating family members are given a structured interview which assesses alcohol and drug problems, and various psychiatric symptoms. The purpose of the present study was to examine the coaggregation of depressive symptoms, antisocial behavior, and alcohol misuse. Multivariate pedigree analyses were performed using a model that allowed for the estimation of vertical familial transmission, residual sibling resemblance, and assortative mating. Spouse correlations were estimated at .57, .21, and .31 for antisocial behavior, depressive symptoms, and alcohol abuse, respectively. Residual sibling environment (i.e., sibling resemblance unaccounted for by parent-offspring transmission) was not found for alcohol problem symptoms, but did contribute to resemblance for antisocial behavior and depressive symptoms. The proportion of variance accounted for by vertical familial transmission was estimated at approximately 30 to 40%. More important, correlations among the transmissible family factors for these psychiatric syndromes ranged from .58 to .73, suggesting substantial overlap among the underlying familial antecedents for these disorders.
Persistent Identifierhttp://hdl.handle.net/10722/143701
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorStallings, MCen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorYoung, SEen_HK
dc.contributor.authorMiles, DRen_HK
dc.contributor.authorHewitt, JKen_HK
dc.contributor.authorFulker, DWen_HK
dc.date.accessioned2011-12-16T08:09:37Z-
dc.date.available2011-12-16T08:09:37Z-
dc.date.issued1997en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1997, v. 74 n. 2, p. 183-191en_HK
dc.identifier.issn0148-7299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143701-
dc.description.abstractThis study describes results from an ongoing family study of adolescent boys and their families designed to investigate potential risk factors for substance abuse. The adolescent treatment probands have severe drug and alcohol related problems and were recruited through a residential rehabilitation program. To date, the sample includes 251 individuals: 39 male probands and their families and 34 control families matched for age and geographic location (zip code). Probands and participating family members are given a structured interview which assesses alcohol and drug problems, and various psychiatric symptoms. The purpose of the present study was to examine the coaggregation of depressive symptoms, antisocial behavior, and alcohol misuse. Multivariate pedigree analyses were performed using a model that allowed for the estimation of vertical familial transmission, residual sibling resemblance, and assortative mating. Spouse correlations were estimated at .57, .21, and .31 for antisocial behavior, depressive symptoms, and alcohol abuse, respectively. Residual sibling environment (i.e., sibling resemblance unaccounted for by parent-offspring transmission) was not found for alcohol problem symptoms, but did contribute to resemblance for antisocial behavior and depressive symptoms. The proportion of variance accounted for by vertical familial transmission was estimated at approximately 30 to 40%. More important, correlations among the transmissible family factors for these psychiatric syndromes ranged from .58 to .73, suggesting substantial overlap among the underlying familial antecedents for these disorders.en_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located aten_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_HK
dc.subjectadolescenceen_HK
dc.subjectalcohol abuseen_HK
dc.subjectantisocial behavioren_HK
dc.subjectcomorbidityen_HK
dc.subjectdepressionen_HK
dc.subjectfamily studyen_HK
dc.titleThe familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuseen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1096-8628(19970418)74:2<183::AID-AJMG14>3.0.CO;2-Een_HK
dc.identifier.pmid9129721-
dc.identifier.scopuseid_2-s2.0-0030951592en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030951592&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue2en_HK
dc.identifier.spage183en_HK
dc.identifier.epage191en_HK
dc.identifier.isiWOS:A1997WV79700014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridStallings, MC=7003293535en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridYoung, SE=7404514524en_HK
dc.identifier.scopusauthoridMiles, DR=7201525219en_HK
dc.identifier.scopusauthoridHewitt, JK=7202713286en_HK
dc.identifier.scopusauthoridFulker, DW=7005792286en_HK

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