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Article: Life events and depression in a community sample of siblings

TitleLife events and depression in a community sample of siblings
Authors
Issue Date2001
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2001, v. 31 n. 3, p. 401-410 How to Cite?
AbstractBackground. The overall aim of the GENESiS project is to identify quantitative trait loci (QTLs) for anxiety/depression, and to examine the interaction between these loci and psychosocial adversity. Here we present life-events data with the aim of clarifying: (i) the aetiology of life events as inferred from sibling correlations; (ii) the relationship between life events and measures of anxiety and depression, as well as neuroticism; and (iii) the interaction between life events and neuroticism on anxiety/depression indices. Methods. We assessed the occurrence of one network and three personal life-event categories and multiple indices of anxiety/depression including General Health Questionnaire, Anhedonic Depression, Anxious Arousal and Neuroticism in a large community-based sample of 2150 sib pairs, 410 trios and 81 quads. Liability threshold models and raw ordinal maximum likelihood were used to estimate within-individual and between-sibling correlations of life events. The relationship between life events and indices of emotional states and personality were assessed by multiple linear regression and canonical correlations. Results. Life events showed sibling correlations of 0·37 for network events and between 0·10 and 0·19 for personal events. Adverse life events were related to anxiety and depression and, to a less extent, neuroticism. Trait-vulnerability (as indexed by co-sib's neuroticism, anxiety and depression) accounted for 11% and life events for 3% of the variance in emotional states. There were no interaction effects. Conclusions. Life events show moderate familiality and are significantly related to symptoms of anxiety and depression in the community. Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety.
Persistent Identifierhttp://hdl.handle.net/10722/143686
ISSN
2014 Impact Factor: 5.938
2014 SCImago Journal Rankings: 2.592
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRijsdijk, FVen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorSterne, Aen_HK
dc.contributor.authorPurcell, Sen_HK
dc.contributor.authorMcGuffin, Pen_HK
dc.contributor.authorFarmer, Aen_HK
dc.contributor.authorGoldberg, Den_HK
dc.contributor.authorMann, Aen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorWebster, Men_HK
dc.contributor.authorBall, Den_HK
dc.contributor.authorEley, TCen_HK
dc.contributor.authorPlomin, Ren_HK
dc.date.accessioned2011-12-16T08:09:29Z-
dc.date.available2011-12-16T08:09:29Z-
dc.date.issued2001en_HK
dc.identifier.citationPsychological Medicine, 2001, v. 31 n. 3, p. 401-410en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143686-
dc.description.abstractBackground. The overall aim of the GENESiS project is to identify quantitative trait loci (QTLs) for anxiety/depression, and to examine the interaction between these loci and psychosocial adversity. Here we present life-events data with the aim of clarifying: (i) the aetiology of life events as inferred from sibling correlations; (ii) the relationship between life events and measures of anxiety and depression, as well as neuroticism; and (iii) the interaction between life events and neuroticism on anxiety/depression indices. Methods. We assessed the occurrence of one network and three personal life-event categories and multiple indices of anxiety/depression including General Health Questionnaire, Anhedonic Depression, Anxious Arousal and Neuroticism in a large community-based sample of 2150 sib pairs, 410 trios and 81 quads. Liability threshold models and raw ordinal maximum likelihood were used to estimate within-individual and between-sibling correlations of life events. The relationship between life events and indices of emotional states and personality were assessed by multiple linear regression and canonical correlations. Results. Life events showed sibling correlations of 0·37 for network events and between 0·10 and 0·19 for personal events. Adverse life events were related to anxiety and depression and, to a less extent, neuroticism. Trait-vulnerability (as indexed by co-sib's neuroticism, anxiety and depression) accounted for 11% and life events for 3% of the variance in emotional states. There were no interaction effects. Conclusions. Life events show moderate familiality and are significantly related to symptoms of anxiety and depression in the community. Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety.en_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.titleLife events and depression in a community sample of siblingsen_HK
dc.typeArticleen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11305848en_HK
dc.identifier.scopuseid_2-s2.0-0035067950en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035067950&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue3en_HK
dc.identifier.spage401en_HK
dc.identifier.epage410en_HK
dc.identifier.isiWOS:000168192700002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridRijsdijk, FV=6701830835en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridSterne, A=6603417496en_HK
dc.identifier.scopusauthoridPurcell, S=7005489464en_HK
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_HK
dc.identifier.scopusauthoridFarmer, A=7102158824en_HK
dc.identifier.scopusauthoridGoldberg, D=7401442597en_HK
dc.identifier.scopusauthoridMann, A=7201627833en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridWebster, M=36485786500en_HK
dc.identifier.scopusauthoridBall, D=7202703810en_HK
dc.identifier.scopusauthoridEley, TC=7003787769en_HK
dc.identifier.scopusauthoridPlomin, R=36050187200en_HK

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