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Article: Life events and depression in a community sample of siblings
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TitleLife events and depression in a community sample of siblings
 
AuthorsRijsdijk, FV1
Sham, PC1
Sterne, A1
Purcell, S1
McGuffin, P1
Farmer, A1
Goldberg, D1
Mann, A1
Cherny, SS1
Webster, M1
Ball, D1
Eley, TC1
Plomin, R1
 
Issue Date2001
 
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
CitationPsychological Medicine, 2001, v. 31 n. 3, p. 401-410 [How to Cite?]
 
AbstractBackground. The overall aim of the GENESiS project is to identify quantitative trait loci (QTLs) for anxiety/depression, and to examine the interaction between these loci and psychosocial adversity. Here we present life-events data with the aim of clarifying: (i) the aetiology of life events as inferred from sibling correlations; (ii) the relationship between life events and measures of anxiety and depression, as well as neuroticism; and (iii) the interaction between life events and neuroticism on anxiety/depression indices. Methods. We assessed the occurrence of one network and three personal life-event categories and multiple indices of anxiety/depression including General Health Questionnaire, Anhedonic Depression, Anxious Arousal and Neuroticism in a large community-based sample of 2150 sib pairs, 410 trios and 81 quads. Liability threshold models and raw ordinal maximum likelihood were used to estimate within-individual and between-sibling correlations of life events. The relationship between life events and indices of emotional states and personality were assessed by multiple linear regression and canonical correlations. Results. Life events showed sibling correlations of 0·37 for network events and between 0·10 and 0·19 for personal events. Adverse life events were related to anxiety and depression and, to a less extent, neuroticism. Trait-vulnerability (as indexed by co-sib's neuroticism, anxiety and depression) accounted for 11% and life events for 3% of the variance in emotional states. There were no interaction effects. Conclusions. Life events show moderate familiality and are significantly related to symptoms of anxiety and depression in the community. Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety.
 
ISSN0033-2917
2013 Impact Factor: 5.428
 
ISI Accession Number IDWOS:000168192700002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorRijsdijk, FV
 
dc.contributor.authorSham, PC
 
dc.contributor.authorSterne, A
 
dc.contributor.authorPurcell, S
 
dc.contributor.authorMcGuffin, P
 
dc.contributor.authorFarmer, A
 
dc.contributor.authorGoldberg, D
 
dc.contributor.authorMann, A
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorWebster, M
 
dc.contributor.authorBall, D
 
dc.contributor.authorEley, TC
 
dc.contributor.authorPlomin, R
 
dc.date.accessioned2011-12-16T08:09:29Z
 
dc.date.available2011-12-16T08:09:29Z
 
dc.date.issued2001
 
dc.description.abstractBackground. The overall aim of the GENESiS project is to identify quantitative trait loci (QTLs) for anxiety/depression, and to examine the interaction between these loci and psychosocial adversity. Here we present life-events data with the aim of clarifying: (i) the aetiology of life events as inferred from sibling correlations; (ii) the relationship between life events and measures of anxiety and depression, as well as neuroticism; and (iii) the interaction between life events and neuroticism on anxiety/depression indices. Methods. We assessed the occurrence of one network and three personal life-event categories and multiple indices of anxiety/depression including General Health Questionnaire, Anhedonic Depression, Anxious Arousal and Neuroticism in a large community-based sample of 2150 sib pairs, 410 trios and 81 quads. Liability threshold models and raw ordinal maximum likelihood were used to estimate within-individual and between-sibling correlations of life events. The relationship between life events and indices of emotional states and personality were assessed by multiple linear regression and canonical correlations. Results. Life events showed sibling correlations of 0·37 for network events and between 0·10 and 0·19 for personal events. Adverse life events were related to anxiety and depression and, to a less extent, neuroticism. Trait-vulnerability (as indexed by co-sib's neuroticism, anxiety and depression) accounted for 11% and life events for 3% of the variance in emotional states. There were no interaction effects. Conclusions. Life events show moderate familiality and are significantly related to symptoms of anxiety and depression in the community. Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationPsychological Medicine, 2001, v. 31 n. 3, p. 401-410 [How to Cite?]
 
dc.identifier.epage410
 
dc.identifier.isiWOS:000168192700002
 
dc.identifier.issn0033-2917
2013 Impact Factor: 5.428
 
dc.identifier.issue3
 
dc.identifier.pmid11305848
 
dc.identifier.scopuseid_2-s2.0-0035067950
 
dc.identifier.spage401
 
dc.identifier.urihttp://hdl.handle.net/10722/143686
 
dc.identifier.volume31
 
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofPsychological Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.titleLife events and depression in a community sample of siblings
 
dc.typeArticle
 
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<description.abstract>Background. The overall aim of the GENESiS project is to identify quantitative trait loci (QTLs) for anxiety/depression, and to examine the interaction between these loci and psychosocial adversity. Here we present life-events data with the aim of clarifying: (i) the aetiology of life events as inferred from sibling correlations; (ii) the relationship between life events and measures of anxiety and depression, as well as neuroticism; and (iii) the interaction between life events and neuroticism on anxiety/depression indices. Methods. We assessed the occurrence of one network and three personal life-event categories and multiple indices of anxiety/depression including General Health Questionnaire, Anhedonic Depression, Anxious Arousal and Neuroticism in a large community-based sample of 2150 sib pairs, 410 trios and 81 quads. Liability threshold models and raw ordinal maximum likelihood were used to estimate within-individual and between-sibling correlations of life events. The relationship between life events and indices of emotional states and personality were assessed by multiple linear regression and canonical correlations. Results. Life events showed sibling correlations of 0&#183;37 for network events and between 0&#183;10 and 0&#183;19 for personal events. Adverse life events were related to anxiety and depression and, to a less extent, neuroticism. Trait-vulnerability (as indexed by co-sib&apos;s neuroticism, anxiety and depression) accounted for 11% and life events for 3% of the variance in emotional states. There were no interaction effects. Conclusions. Life events show moderate familiality and are significantly related to symptoms of anxiety and depression in the community. Appropriate modelling of life events in linkage and association analyses should help to identify QTLs for depression and anxiety.</description.abstract>
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Author Affiliations
  1. King's College London