File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Optimal sibship selection for genotyping in quantitative trait locus linkage analysis

TitleOptimal sibship selection for genotyping in quantitative trait locus linkage analysis
Authors
KeywordsLinkage
Methodology
Quantitative trait loci
Selection
Sibs
Variance components
Issue Date2001
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHE
Citation
Human Heredity, 2001, v. 52 n. 1, p. 1-13 How to Cite?
AbstractIn this paper we present a novel method for selecting optimally informative sibships of any size for quantitative trait locus (QTL) linkage analysis. The method allocates a quantitative index of potential informativeness to each sibship on the basis of observed trait scores and an assumed true QTL model. Any sample of phenotypically screened sibships can therefore be easily rank-ordered for selective genotyping. The quantitative index is the sibship's expected contribution to the non-centrality parameter. This expectation represents the weighted sum of χ2 test statistics that would be obtained given the observed trait values over all possible sibship genotypic configurations; each configuration is weighted by the likelihood of it occurring given the assumed true genetic model. The properties of this procedure are explored in relation to the accuracy of the assumed true genetic model and sibship size. In comparison to previous methods of selecting phenotypically extreme sibships for genotyping, the proposed method is considerably more efficient and is robust with regard to the specification of the genetic model. Copyright © 2001 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/143680
ISSN
2014 Impact Factor: 1.474
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPurcell, Sen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorHewitt, JKen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2011-12-16T08:09:25Z-
dc.date.available2011-12-16T08:09:25Z-
dc.date.issued2001en_HK
dc.identifier.citationHuman Heredity, 2001, v. 52 n. 1, p. 1-13en_HK
dc.identifier.issn0001-5652en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143680-
dc.description.abstractIn this paper we present a novel method for selecting optimally informative sibships of any size for quantitative trait locus (QTL) linkage analysis. The method allocates a quantitative index of potential informativeness to each sibship on the basis of observed trait scores and an assumed true QTL model. Any sample of phenotypically screened sibships can therefore be easily rank-ordered for selective genotyping. The quantitative index is the sibship's expected contribution to the non-centrality parameter. This expectation represents the weighted sum of χ2 test statistics that would be obtained given the observed trait values over all possible sibship genotypic configurations; each configuration is weighted by the likelihood of it occurring given the assumed true genetic model. The properties of this procedure are explored in relation to the accuracy of the assumed true genetic model and sibship size. In comparison to previous methods of selecting phenotypically extreme sibships for genotyping, the proposed method is considerably more efficient and is robust with regard to the specification of the genetic model. Copyright © 2001 S. Karger AG, Basel.en_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/HHEen_HK
dc.relation.ispartofHuman Heredityen_HK
dc.subjectLinkageen_HK
dc.subjectMethodologyen_HK
dc.subjectQuantitative trait locien_HK
dc.subjectSelectionen_HK
dc.subjectSibsen_HK
dc.subjectVariance componentsen_HK
dc.titleOptimal sibship selection for genotyping in quantitative trait locus linkage analysisen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000053350en_HK
dc.identifier.pmid11359064en_HK
dc.identifier.scopuseid_2-s2.0-0035007458en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035007458&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage13en_HK
dc.identifier.isiWOS:000168976300001-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridPurcell, S=7005489464en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridHewitt, JK=7202713286en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats