Article: Optimal sibship selection for genotyping in quantitative trait locus linkage analysis

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- Cherny, Stacey Shawn
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Publisher Website: 10.1159/000053350
Scopus: eid_2-s2.0-0035007458
PMID: 11359064

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Title	Optimal sibship selection for genotyping in quantitative trait locus linkage analysis
Authors	Purcell, S1 2 Cherny, SS1 4 Hewitt, JK3 Sham, PC1
Keywords	Linkage Methodology Quantitative trait loci Selection Sibs Variance components
Issue Date	2001
Publisher	S Karger AG. The Journal's web site is located at http://www.karger.com/HHE
Citation	Human Heredity, 2001, v. 52 n. 1, p. 1-13 [How to Cite?] DOI: http://dx.doi.org/10.1159/000053350
Abstract	In this paper we present a novel method for selecting optimally informative sibships of any size for quantitative trait locus (QTL) linkage analysis. The method allocates a quantitative index of potential informativeness to each sibship on the basis of observed trait scores and an assumed true QTL model. Any sample of phenotypically screened sibships can therefore be easily rank-ordered for selective genotyping. The quantitative index is the sibship's expected contribution to the non-centrality parameter. This expectation represents the weighted sum of χ2 test statistics that would be obtained given the observed trait values over all possible sibship genotypic configurations; each configuration is weighted by the likelihood of it occurring given the assumed true genetic model. The properties of this procedure are explored in relation to the accuracy of the assumed true genetic model and sibship size. In comparison to previous methods of selecting phenotypically extreme sibships for genotyping, the proposed method is considerably more efficient and is robust with regard to the specification of the genetic model. Copyright © 2001 S. Karger AG, Basel.
ISSN	0001-5652 2011 Impact Factor: 1.789 2011 SCImago Journal Rankings: 0.335
DOI	http://dx.doi.org/10.1159/000053350
ISI Accession Number ID	WOS:000168976300001
References	References in Scopus

DC Field	Value
dc.contributor.author	Purcell, S
dc.contributor.author	Cherny, SS
dc.contributor.author	Hewitt, JK
dc.contributor.author	Sham, PC
dc.date.accessioned	2011-12-16T08:09:25Z
dc.date.available	2011-12-16T08:09:25Z
dc.date.issued	2001
dc.description.abstract	In this paper we present a novel method for selecting optimally informative sibships of any size for quantitative trait locus (QTL) linkage analysis. The method allocates a quantitative index of potential informativeness to each sibship on the basis of observed trait scores and an assumed true QTL model. Any sample of phenotypically screened sibships can therefore be easily rank-ordered for selective genotyping. The quantitative index is the sibship's expected contribution to the non-centrality parameter. This expectation represents the weighted sum of χ2 test statistics that would be obtained given the observed trait values over all possible sibship genotypic configurations; each configuration is weighted by the likelihood of it occurring given the assumed true genetic model. The properties of this procedure are explored in relation to the accuracy of the assumed true genetic model and sibship size. In comparison to previous methods of selecting phenotypically extreme sibships for genotyping, the proposed method is considerably more efficient and is robust with regard to the specification of the genetic model. Copyright © 2001 S. Karger AG, Basel.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Human Heredity, 2001, v. 52 n. 1, p. 1-13 [How to Cite?] DOI: http://dx.doi.org/10.1159/000053350
dc.identifier.doi	http://dx.doi.org/10.1159/000053350
dc.identifier.epage	13
dc.identifier.isi	WOS:000168976300001
dc.identifier.issn	0001-5652 2011 Impact Factor: 1.789 2011 SCImago Journal Rankings: 0.335
dc.identifier.issue	1
dc.identifier.pmid	11359064
dc.identifier.scopus	eid_2-s2.0-0035007458
dc.identifier.spage	1
dc.identifier.uri	http://hdl.handle.net/10722/143680
dc.identifier.volume	52
dc.publisher	S Karger AG. The Journal's web site is located at http://www.karger.com/HHE
dc.publisher.place	Switzerland
dc.relation.ispartof	Human Heredity
dc.relation.references	References in Scopus
dc.subject	Linkage
dc.subject	Methodology
dc.subject	Quantitative trait loci
dc.subject	Selection
dc.subject	Sibs
dc.subject	Variance components
dc.title	Optimal sibship selection for genotyping in quantitative trait locus linkage analysis
dc.type	Article

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SGDP Research Centre
University of Colorado at Boulder
Wellcome Trust Centre for Human Genetics

Article: Optimal sibship selection for genotyping in quantitative trait locus linkage analysis

The HKU Scholars Hub has contact details for these author(s).