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Article: Distinguishing population stratification from genuine allelic effects with Mx: Association of ADH2 with alcohol consumption

TitleDistinguishing population stratification from genuine allelic effects with Mx: Association of ADH2 with alcohol consumption
Authors
KeywordsADH2
Admixture
Alcohol consumption
Genetic association
Identical by descent (IBD)
Linkage
Linkage disequilibrium
Mx
Population stratification
Statistical model
Twins
Issue Date1999
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244
Citation
Behavior Genetics, 1999, v. 29 n. 4, p. 233-243 How to Cite?
AbstractA universal problem in genetic association studies is to distinguish associations due to genuine effects of the locus under investigation, or linkage disequilibrium with a nearby locus that has a genuine effect, from associations due to population stratification or other artifacts. Fulker et al. (1999) have suggested a test using unselected sib pairs to distinguish these two causes of association. The test is readily implemented within a standard maximum-likelihood framework using the Mx package. The approach is applied to data on ADH2 genotypes and a measure of alcohol consumption from an Australian DZ twin pair sample. Results indicate that the association of the ADH2*2 allele with lower alcohol consumption cannot be explained by simple admixture and that there may be genuine allelic effects of the locus on alcohol consumption. Power calculations are provided to show that these results are plausible for the sample size in this study and consider the effects of genetic architecture and sample structure on required sample sizes for the Fulker et al. test.
Persistent Identifierhttp://hdl.handle.net/10722/143671
ISSN
2015 Impact Factor: 3.268
2015 SCImago Journal Rankings: 1.457
References

 

DC FieldValueLanguage
dc.contributor.authorNeale, MCen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorWhitfield, JBen_HK
dc.contributor.authorHeath, ACen_HK
dc.contributor.authorBirley, AJen_HK
dc.contributor.authorMartin, NGen_HK
dc.date.accessioned2011-12-16T08:09:20Z-
dc.date.available2011-12-16T08:09:20Z-
dc.date.issued1999en_HK
dc.identifier.citationBehavior Genetics, 1999, v. 29 n. 4, p. 233-243en_HK
dc.identifier.issn0001-8244en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143671-
dc.description.abstractA universal problem in genetic association studies is to distinguish associations due to genuine effects of the locus under investigation, or linkage disequilibrium with a nearby locus that has a genuine effect, from associations due to population stratification or other artifacts. Fulker et al. (1999) have suggested a test using unselected sib pairs to distinguish these two causes of association. The test is readily implemented within a standard maximum-likelihood framework using the Mx package. The approach is applied to data on ADH2 genotypes and a measure of alcohol consumption from an Australian DZ twin pair sample. Results indicate that the association of the ADH2*2 allele with lower alcohol consumption cannot be explained by simple admixture and that there may be genuine allelic effects of the locus on alcohol consumption. Power calculations are provided to show that these results are plausible for the sample size in this study and consider the effects of genetic architecture and sample structure on required sample sizes for the Fulker et al. test.en_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244en_HK
dc.relation.ispartofBehavior Geneticsen_HK
dc.subjectADH2en_HK
dc.subjectAdmixtureen_HK
dc.subjectAlcohol consumptionen_HK
dc.subjectGenetic associationen_HK
dc.subjectIdentical by descent (IBD)en_HK
dc.subjectLinkageen_HK
dc.subjectLinkage disequilibriumen_HK
dc.subjectMxen_HK
dc.subjectPopulation stratificationen_HK
dc.subjectStatistical modelen_HK
dc.subjectTwinsen_HK
dc.titleDistinguishing population stratification from genuine allelic effects with Mx: Association of ADH2 with alcohol consumptionen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0032709969en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032709969&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue4en_HK
dc.identifier.spage233en_HK
dc.identifier.epage243en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNeale, MC=35418917800en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridWhitfield, JB=16187873900en_HK
dc.identifier.scopusauthoridHeath, AC=7201835346en_HK
dc.identifier.scopusauthoridBirley, AJ=7006130385en_HK
dc.identifier.scopusauthoridMartin, NG=35376988300en_HK

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