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Article: Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships

TitleGenome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2004, v. 13 n. 19, p. 2173-2182 How to Cite?
AbstractThere is considerable evidence to suggest that the genetic vulnerabilities to depression and anxiety substantially overlap and quantitatively act to alter risk to both disorders. Continuous scales can be used to index this shared liability and are a complementary approach to the use of clinical phenotypes in the genetic analysis of depression and anxiety. The aim of this study (Genetic and Environmental Nature of Emotional States in Siblings) was to identify genetic variants for the liability to depression and anxiety after the application of quantitative genetic methodology to a large community-based sample (n = 34 371), using four well-validated questionnaires of depression and anxiety. Genetic model fitting was performed on 2658 unselected sibships, which provided evidence for a single common familial factor that accounted for a substantial proportion of the genetic variances and covariances of the four scales. Using the parameter estimates from this model, a composite index of liability (G) was constructed. This index was then used to select a smaller - but statistically powerful - sample for DNA collection (757 individuals, 297 sibships). These individuals were genotyped with more than 400 microsatellite markers. After the data were checked and cleaned, linkage analysis was performed on G and the personality scale of neuroticism using the regression-based linkage program MERLIN-REGRESS. The results indicated two potential quantitative trait loci (QTL): one on chromosome 1p (LOD 2.2) around 64 cM (43-70 cM) near marker D1S2892 and another on chromosome 6p (LOD 2.7) around 47 cM (34-63 cM) near marker D6S1610. Further exploratory sex-specific analyses suggested that these QTLs might have sex-limited effects. © Oxford University Press 2004; all rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/143669
ISSN
2014 Impact Factor: 6.393
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNash, MWen_HK
dc.contributor.authorHuezoDiaz, Pen_HK
dc.contributor.authorWilliamson, RJen_HK
dc.contributor.authorSterne, Aen_HK
dc.contributor.authorPurcell, Sen_HK
dc.contributor.authorHoda, Fen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorAbecasis, Gen_HK
dc.contributor.authorPrince, Men_HK
dc.contributor.authorGray, JAen_HK
dc.contributor.authorBall, Den_HK
dc.contributor.authorAsherson, Pen_HK
dc.contributor.authorMann, Aen_HK
dc.contributor.authorGoldberg, Den_HK
dc.contributor.authorMcGuffin, Pen_HK
dc.contributor.authorFarmer, Aen_HK
dc.contributor.authorPlomin, Ren_HK
dc.contributor.authorCraig, IWen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2011-12-16T08:09:19Z-
dc.date.available2011-12-16T08:09:19Z-
dc.date.issued2004en_HK
dc.identifier.citationHuman Molecular Genetics, 2004, v. 13 n. 19, p. 2173-2182en_HK
dc.identifier.issn0964-6906en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143669-
dc.description.abstractThere is considerable evidence to suggest that the genetic vulnerabilities to depression and anxiety substantially overlap and quantitatively act to alter risk to both disorders. Continuous scales can be used to index this shared liability and are a complementary approach to the use of clinical phenotypes in the genetic analysis of depression and anxiety. The aim of this study (Genetic and Environmental Nature of Emotional States in Siblings) was to identify genetic variants for the liability to depression and anxiety after the application of quantitative genetic methodology to a large community-based sample (n = 34 371), using four well-validated questionnaires of depression and anxiety. Genetic model fitting was performed on 2658 unselected sibships, which provided evidence for a single common familial factor that accounted for a substantial proportion of the genetic variances and covariances of the four scales. Using the parameter estimates from this model, a composite index of liability (G) was constructed. This index was then used to select a smaller - but statistically powerful - sample for DNA collection (757 individuals, 297 sibships). These individuals were genotyped with more than 400 microsatellite markers. After the data were checked and cleaned, linkage analysis was performed on G and the personality scale of neuroticism using the regression-based linkage program MERLIN-REGRESS. The results indicated two potential quantitative trait loci (QTL): one on chromosome 1p (LOD 2.2) around 64 cM (43-70 cM) near marker D1S2892 and another on chromosome 6p (LOD 2.7) around 47 cM (34-63 cM) near marker D6S1610. Further exploratory sex-specific analyses suggested that these QTLs might have sex-limited effects. © Oxford University Press 2004; all rights reserved.en_HK
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Molecular Geneticsen_HK
dc.titleGenome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibshipsen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/hmg/ddh239en_HK
dc.identifier.pmid15351774en_HK
dc.identifier.scopuseid_2-s2.0-5444275087en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-5444275087&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue19en_HK
dc.identifier.spage2173en_HK
dc.identifier.epage2182en_HK
dc.identifier.isiWOS:000223941500002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNash, MW=8771626900en_HK
dc.identifier.scopusauthoridHuezoDiaz, P=6506170044en_HK
dc.identifier.scopusauthoridWilliamson, RJ=7401944359en_HK
dc.identifier.scopusauthoridSterne, A=8771625100en_HK
dc.identifier.scopusauthoridPurcell, S=7005489464en_HK
dc.identifier.scopusauthoridHoda, F=6505990749en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridAbecasis, G=6604013253en_HK
dc.identifier.scopusauthoridPrince, M=23986134300en_HK
dc.identifier.scopusauthoridGray, JA=7404300712en_HK
dc.identifier.scopusauthoridBall, D=7202703810en_HK
dc.identifier.scopusauthoridAsherson, P=35402700900en_HK
dc.identifier.scopusauthoridMann, A=7201627833en_HK
dc.identifier.scopusauthoridGoldberg, D=7401442597en_HK
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_HK
dc.identifier.scopusauthoridFarmer, A=7102158824en_HK
dc.identifier.scopusauthoridPlomin, R=36050187200en_HK
dc.identifier.scopusauthoridCraig, IW=7102548208en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.citeulike3037303-

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