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Article: Use of multivariate linkage analysis for dissection of a complex cognitive trait

TitleUse of multivariate linkage analysis for dissection of a complex cognitive trait
Authors
Issue Date2003
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
Citation
American Journal Of Human Genetics, 2003, v. 72 n. 3, p. 561-570 How to Cite?
AbstractReplication of linkage results for complex traits has been exceedingly difficult, owing in part to the inability to measure the precise underlying phenotype, small sample sizes, genetic heterogeneity, and statistical methods employed in analysis. Often, in any particular study, multiple correlated traits have been collected, yet these have been analyzed independently or, at most, in bivariate analyses. Theoretical arguments suggest that full multivariate analysis of all available traits should offer more power to detect linkage; however, this has not yet been evaluated on a genomewide scale. Here, we conduct multivariate genomewide analyses of quantitative-trait loci that influence reading- and language-related measures in families affected with developmental dyslexia. The results of these analyses are substantially clearer than those of previous univariate analyses of the same data set, helping to resolve a number of key issues. These outcomes highlight the relevance of multivariate analysis for complex disorders for dissection of linkage results in correlated traits. The approach employed here may aid positional cloning of susceptibility genes in a wide spectrum of complex traits.
Persistent Identifierhttp://hdl.handle.net/10722/143668
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMarlow, AJen_HK
dc.contributor.authorFisher, SEen_HK
dc.contributor.authorFrancks, Cen_HK
dc.contributor.authorMacPhie, ILen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorRichardson, AJen_HK
dc.contributor.authorTalcott, JBen_HK
dc.contributor.authorStein, JFen_HK
dc.contributor.authorMonaco, APen_HK
dc.contributor.authorCardon, LRen_HK
dc.date.accessioned2011-12-16T08:09:16Z-
dc.date.available2011-12-16T08:09:16Z-
dc.date.issued2003en_HK
dc.identifier.citationAmerican Journal Of Human Genetics, 2003, v. 72 n. 3, p. 561-570en_HK
dc.identifier.issn0002-9297en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143668-
dc.description.abstractReplication of linkage results for complex traits has been exceedingly difficult, owing in part to the inability to measure the precise underlying phenotype, small sample sizes, genetic heterogeneity, and statistical methods employed in analysis. Often, in any particular study, multiple correlated traits have been collected, yet these have been analyzed independently or, at most, in bivariate analyses. Theoretical arguments suggest that full multivariate analysis of all available traits should offer more power to detect linkage; however, this has not yet been evaluated on a genomewide scale. Here, we conduct multivariate genomewide analyses of quantitative-trait loci that influence reading- and language-related measures in families affected with developmental dyslexia. The results of these analyses are substantially clearer than those of previous univariate analyses of the same data set, helping to resolve a number of key issues. These outcomes highlight the relevance of multivariate analysis for complex disorders for dissection of linkage results in correlated traits. The approach employed here may aid positional cloning of susceptibility genes in a wide spectrum of complex traits.en_HK
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/en_HK
dc.relation.ispartofAmerican Journal of Human Geneticsen_HK
dc.titleUse of multivariate linkage analysis for dissection of a complex cognitive traiten_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1086/368201en_HK
dc.identifier.pmid12587094-
dc.identifier.scopuseid_2-s2.0-0037371605en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037371605&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume72en_HK
dc.identifier.issue3en_HK
dc.identifier.spage561en_HK
dc.identifier.epage570en_HK
dc.identifier.isiWOS:000181152600006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001003588-
dc.identifier.scopusauthoridMarlow, AJ=7004140967en_HK
dc.identifier.scopusauthoridFisher, SE=7401755825en_HK
dc.identifier.scopusauthoridFrancks, C=6603599497en_HK
dc.identifier.scopusauthoridMacPhie, IL=6602915370en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridRichardson, AJ=35472888000en_HK
dc.identifier.scopusauthoridTalcott, JB=7006209587en_HK
dc.identifier.scopusauthoridStein, JF=7402750907en_HK
dc.identifier.scopusauthoridMonaco, AP=7201638991en_HK
dc.identifier.scopusauthoridCardon, LR=7005082964en_HK

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