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Article: Quantitative-trait locus for specific language and reading deficits on chromosome 6p

TitleQuantitative-trait locus for specific language and reading deficits on chromosome 6p
Authors
Issue Date1999
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
Citation
American Journal Of Human Genetics, 1999, v. 64 n. 1, p. 157-164 How to Cite?
AbstractReading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.
Persistent Identifierhttp://hdl.handle.net/10722/143657
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGayán, Jen_HK
dc.contributor.authorSmith, SDen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorCardon, LRen_HK
dc.contributor.authorFulker, DWen_HK
dc.contributor.authorBrower, AMen_HK
dc.contributor.authorOlson, RKen_HK
dc.contributor.authorPennington, BFen_HK
dc.contributor.authorDeFries, JCen_HK
dc.date.accessioned2011-12-16T08:09:05Z-
dc.date.available2011-12-16T08:09:05Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal Of Human Genetics, 1999, v. 64 n. 1, p. 157-164en_HK
dc.identifier.issn0002-9297en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143657-
dc.description.abstractReading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.en_HK
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/en_HK
dc.relation.ispartofAmerican Journal of Human Geneticsen_HK
dc.titleQuantitative-trait locus for specific language and reading deficits on chromosome 6pen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1086/302191en_HK
dc.identifier.pmid9915954-
dc.identifier.scopuseid_2-s2.0-0033364213en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033364213&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue1en_HK
dc.identifier.spage157en_HK
dc.identifier.epage164en_HK
dc.identifier.isiWOS:000078477400020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGayán, J=6603558565en_HK
dc.identifier.scopusauthoridSmith, SD=7406648635en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridCardon, LR=7005082964en_HK
dc.identifier.scopusauthoridFulker, DW=7005792286en_HK
dc.identifier.scopusauthoridBrower, AM=35966543900en_HK
dc.identifier.scopusauthoridOlson, RK=7402602725en_HK
dc.identifier.scopusauthoridPennington, BF=7007139540en_HK
dc.identifier.scopusauthoridDeFries, JC=7005658115en_HK
dc.identifier.citeulike7501867-

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