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Article: Combined linkage and association sib-pair analysis for quantitative traits

TitleCombined linkage and association sib-pair analysis for quantitative traits
Authors
Issue Date1999
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
Citation
American Journal Of Human Genetics, 1999, v. 64 n. 1, p. 259-267 How to Cite?
AbstractAn extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.
Persistent Identifierhttp://hdl.handle.net/10722/143654
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFulker, DWen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorHewitt, JKen_HK
dc.date.accessioned2011-12-16T08:08:42Z-
dc.date.available2011-12-16T08:08:42Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal Of Human Genetics, 1999, v. 64 n. 1, p. 259-267en_HK
dc.identifier.issn0002-9297en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143654-
dc.description.abstractAn extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.en_HK
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/en_HK
dc.relation.ispartofAmerican Journal of Human Geneticsen_HK
dc.titleCombined linkage and association sib-pair analysis for quantitative traitsen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1086/302193en_HK
dc.identifier.pmid9915965-
dc.identifier.scopuseid_2-s2.0-0033366671en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033366671&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue1en_HK
dc.identifier.spage259en_HK
dc.identifier.epage267en_HK
dc.identifier.isiWOS:000078477400031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFulker, DW=7005792286en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridHewitt, JK=7202713286en_HK

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