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Article: Multipoint interval mapping of quantitative trait loci, using sib pairs

TitleMultipoint interval mapping of quantitative trait loci, using sib pairs
Authors
Issue Date1995
PublisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/
Citation
American Journal Of Human Genetics, 1995, v. 56 n. 5, p. 1224-1233 How to Cite?
AbstractThe sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.
Persistent Identifierhttp://hdl.handle.net/10722/143653
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFulker, DWen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorCardon, LRen_HK
dc.date.accessioned2011-12-16T08:08:42Z-
dc.date.available2011-12-16T08:08:42Z-
dc.date.issued1995en_HK
dc.identifier.citationAmerican Journal Of Human Genetics, 1995, v. 56 n. 5, p. 1224-1233en_HK
dc.identifier.issn0002-9297en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143653-
dc.description.abstractThe sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.en_HK
dc.publisherCell Press. The Journal's web site is located at http://www.cell.com/AJHG/en_HK
dc.relation.ispartofAmerican Journal of Human Geneticsen_HK
dc.titleMultipoint interval mapping of quantitative trait loci, using sib pairsen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7726180-
dc.identifier.scopuseid_2-s2.0-0028947057en_HK
dc.identifier.volume56en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1224en_HK
dc.identifier.epage1233en_HK
dc.identifier.isiWOS:A1995QU58600027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFulker, DW=7005792286en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridCardon, LR=7005082964en_HK

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