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- Publisher Website: 10.1007/BF02359758
- Scopus: eid_2-s2.0-0029911351
- PMID: 8917952
- WOS: WOS:A1996VN23100010
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Article: An improved multipoint sib-pair analysis of quantitative traits
Title | An improved multipoint sib-pair analysis of quantitative traits |
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Authors | |
Keywords | identical by descent marker alleles maximum likelihood Multipoint sib-pair analysis quantitative traits |
Issue Date | 1996 |
Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244 |
Citation | Behavior Genetics, 1996, v. 26 n. 5, p. 527-532 How to Cite? |
Abstract | Kruglyak and Lander (1995) recently published a multipoint sib-pair procedure based on the expected distribution of zero, one and two marker alleles shared identical by descent (ibd) and the method of maximum- likelihood (ML). Their approach uses phenotypic sib-pair differences, which ignores the bivariate structure of sib-pair data. Their simulations suggested that their method was more powerful than the regression method of Haseman and Elston (1972). We show through computation and simulation that their approach can be made more powerful still if the bivariate nature of sib-pair data is acknowledged. In addition, methods based on the average number of shared alleles that also employ bivariate ML procedures (Nance and Neale, 1989; Xu and Atchley, 1995) are more powerful than the approach they recommend and very similar to true ML using the distribution of ibd. The simple ML approach using the average number of shared alleles that we recommend seems to offer both optimal power and flexibility. |
Persistent Identifier | http://hdl.handle.net/10722/143651 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 1.092 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fulker, DW | en_HK |
dc.contributor.author | Cherny, SS | en_HK |
dc.date.accessioned | 2011-12-16T08:08:41Z | - |
dc.date.available | 2011-12-16T08:08:41Z | - |
dc.date.issued | 1996 | en_HK |
dc.identifier.citation | Behavior Genetics, 1996, v. 26 n. 5, p. 527-532 | en_HK |
dc.identifier.issn | 0001-8244 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/143651 | - |
dc.description.abstract | Kruglyak and Lander (1995) recently published a multipoint sib-pair procedure based on the expected distribution of zero, one and two marker alleles shared identical by descent (ibd) and the method of maximum- likelihood (ML). Their approach uses phenotypic sib-pair differences, which ignores the bivariate structure of sib-pair data. Their simulations suggested that their method was more powerful than the regression method of Haseman and Elston (1972). We show through computation and simulation that their approach can be made more powerful still if the bivariate nature of sib-pair data is acknowledged. In addition, methods based on the average number of shared alleles that also employ bivariate ML procedures (Nance and Neale, 1989; Xu and Atchley, 1995) are more powerful than the approach they recommend and very similar to true ML using the distribution of ibd. The simple ML approach using the average number of shared alleles that we recommend seems to offer both optimal power and flexibility. | en_HK |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244 | en_HK |
dc.relation.ispartof | Behavior Genetics | en_HK |
dc.subject | identical by descent | en_HK |
dc.subject | marker alleles | en_HK |
dc.subject | maximum likelihood | en_HK |
dc.subject | Multipoint sib-pair analysis | en_HK |
dc.subject | quantitative traits | en_HK |
dc.title | An improved multipoint sib-pair analysis of quantitative traits | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Cherny, SS: cherny@hku.hk | en_HK |
dc.identifier.authority | Cherny, SS=rp00232 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/BF02359758 | en_HK |
dc.identifier.pmid | 8917952 | - |
dc.identifier.scopus | eid_2-s2.0-0029911351 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029911351&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 26 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 527 | en_HK |
dc.identifier.epage | 532 | en_HK |
dc.identifier.isi | WOS:A1996VN23100010 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Fulker, DW=7005792286 | en_HK |
dc.identifier.scopusauthorid | Cherny, SS=7004670001 | en_HK |
dc.identifier.issnl | 0001-8244 | - |