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Article: A first stage genome-wide screen for regions shared identical-by-descent in hutterite families with multiple sclerosis

TitleA first stage genome-wide screen for regions shared identical-by-descent in hutterite families with multiple sclerosis
Authors
KeywordsHaplotype
Hutterite
MHC
Multiple sclerosis
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 4, p. 467-472 How to Cite?
AbstractThe complexity of multiple sclerosis (MS) genetics has made the search for novel genes using traditional sharing methods problematic. In order to minimize the genetic heterogeneity present in the MS population we have screened the Canadian MS population for individuals belonging to the Hutterite Brethren. Seven Hutterites with clinically definite MS were ascertained and are related to a common founder by eight generations. Six of the 7 affected individuals and 21 of their unaffected family members (total = 27) were genotyped for 807 markers. Haplotypes were then inspected for sharing among the six MS patients. There were three haplotypes shared among all six MS patients. The haplotypes were located at 2q34-35, 4q31-32, and 17p13. An additional 15 haplotypes were shared among five of the six Hutterites MS patients. The HLA Class II region was one of the highlighted regions; however, the shared MHC haplotype bore the DRB1*04 allele and not the MS-associated DRB1*15 allele providing further evidence of the complexity of the MHC. Additional genotyping to refine the haplotypes followed by screening for potential variants may lead to the identification of a novel MS susceptibility gene(s) in this unique population. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/143649
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDyment, DAen_HK
dc.contributor.authorCader, MZen_HK
dc.contributor.authorDatta, Aen_HK
dc.contributor.authorBroxholme, SJen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorWiller, CJen_HK
dc.contributor.authorRamagopalan, Sen_HK
dc.contributor.authorHerrera, BMen_HK
dc.contributor.authorOrton, Sen_HK
dc.contributor.authorChao, Men_HK
dc.contributor.authorSadovnick, ADen_HK
dc.contributor.authorHader, Men_HK
dc.contributor.authorHader, Wen_HK
dc.contributor.authorEbers, GCen_HK
dc.date.accessioned2011-12-16T08:08:40Z-
dc.date.available2011-12-16T08:08:40Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 4, p. 467-472en_HK
dc.identifier.issn1552-4841en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143649-
dc.description.abstractThe complexity of multiple sclerosis (MS) genetics has made the search for novel genes using traditional sharing methods problematic. In order to minimize the genetic heterogeneity present in the MS population we have screened the Canadian MS population for individuals belonging to the Hutterite Brethren. Seven Hutterites with clinically definite MS were ascertained and are related to a common founder by eight generations. Six of the 7 affected individuals and 21 of their unaffected family members (total = 27) were genotyped for 807 markers. Haplotypes were then inspected for sharing among the six MS patients. There were three haplotypes shared among all six MS patients. The haplotypes were located at 2q34-35, 4q31-32, and 17p13. An additional 15 haplotypes were shared among five of the six Hutterites MS patients. The HLA Class II region was one of the highlighted regions; however, the shared MHC haplotype bore the DRB1*04 allele and not the MS-associated DRB1*15 allele providing further evidence of the complexity of the MHC. Additional genotyping to refine the haplotypes followed by screening for potential variants may lead to the identification of a novel MS susceptibility gene(s) in this unique population. © 2007 Wiley-Liss, Inc.en_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Geneticsen_HK
dc.subjectHaplotypeen_HK
dc.subjectHutteriteen_HK
dc.subjectMHCen_HK
dc.subjectMultiple sclerosisen_HK
dc.titleA first stage genome-wide screen for regions shared identical-by-descent in hutterite families with multiple sclerosisen_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ajmg.b.30620en_HK
dc.identifier.pmid18081025-
dc.identifier.scopuseid_2-s2.0-45149127094en_HK
dc.identifier.hkuros145502-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-45149127094&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume147en_HK
dc.identifier.issue4en_HK
dc.identifier.spage467en_HK
dc.identifier.epage472en_HK
dc.identifier.isiWOS:000256331000010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridDyment, DA=6603145913en_HK
dc.identifier.scopusauthoridCader, MZ=20933757900en_HK
dc.identifier.scopusauthoridDatta, A=16027753200en_HK
dc.identifier.scopusauthoridBroxholme, SJ=55275415700en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridWiller, CJ=6602404452en_HK
dc.identifier.scopusauthoridRamagopalan, S=14049256200en_HK
dc.identifier.scopusauthoridHerrera, BM=8859807100en_HK
dc.identifier.scopusauthoridOrton, S=14834203300en_HK
dc.identifier.scopusauthoridChao, M=22955246800en_HK
dc.identifier.scopusauthoridSadovnick, AD=7005523120en_HK
dc.identifier.scopusauthoridHader, M=51563740000en_HK
dc.identifier.scopusauthoridHader, W=7003933740en_HK
dc.identifier.scopusauthoridEbers, GC=15219142200en_HK

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