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Conference Paper: Selecting maximally informative sibships for QTL linkage analysis

TitleSelecting maximally informative sibships for QTL linkage analysis
Authors
Issue Date1999
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244
Citation
The Behavior Genetics Association Meeting: Abstracts. In Behavior Genetics, 1999, v. 29 n. 5, p. 352 How to Cite?
AbstractMuch work has been done in the area of increasing power of linkage studies by use of selective sampling. It is generally known that maximally discordant sib pairs are most informative, although affected pairs can be more informative still in the presence of a rare recessive. However, little work has been done in the area of construction of an optimal sample, once the sample size for genotyping has been determined. For example, clearly even under a simple additive model, the most extremely affected pairs will be more informative than all but the most extremely discordant pairs. When conducting a large-scale study where all sibships have been phenotyped and the next task is to select the potentially most informative sibships or members of a sibship for genotyping, a method for rank ordering all the sibships in a study by their potential informativeness for linkage would be most desirable. This will describe such a method and its implementation in a freely distributed Fortran program.
DescriptionThis journal issue pp. 349-375 entitled: Behavior Genetics Association Meeting: Abstracts
Persistent Identifierhttp://hdl.handle.net/10722/143645
ISSN
2015 Impact Factor: 3.268
2015 SCImago Journal Rankings: 1.457

 

DC FieldValueLanguage
dc.contributor.authorCherny, SSen_US
dc.contributor.authorPurcell, Sen_US
dc.contributor.authorRijsdijk, Fen_US
dc.contributor.authorHewitt, JKen_US
dc.contributor.authorSham, PCen_US
dc.date.accessioned2011-12-16T08:08:26Z-
dc.date.available2011-12-16T08:08:26Z-
dc.date.issued1999en_US
dc.identifier.citationThe Behavior Genetics Association Meeting: Abstracts. In Behavior Genetics, 1999, v. 29 n. 5, p. 352en_US
dc.identifier.issn0001-8244en_US
dc.identifier.urihttp://hdl.handle.net/10722/143645-
dc.descriptionThis journal issue pp. 349-375 entitled: Behavior Genetics Association Meeting: Abstracts-
dc.description.abstractMuch work has been done in the area of increasing power of linkage studies by use of selective sampling. It is generally known that maximally discordant sib pairs are most informative, although affected pairs can be more informative still in the presence of a rare recessive. However, little work has been done in the area of construction of an optimal sample, once the sample size for genotyping has been determined. For example, clearly even under a simple additive model, the most extremely affected pairs will be more informative than all but the most extremely discordant pairs. When conducting a large-scale study where all sibships have been phenotyped and the next task is to select the potentially most informative sibships or members of a sibship for genotyping, a method for rank ordering all the sibships in a study by their potential informativeness for linkage would be most desirable. This will describe such a method and its implementation in a freely distributed Fortran program.-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244en_US
dc.relation.ispartofBehavior Geneticsen_US
dc.titleSelecting maximally informative sibships for QTL linkage analysisen_US
dc.typeConference_Paperen_US
dc.identifier.emailCherny, SS: cherny@hku.hken_US
dc.identifier.authorityCherny, SS=rp00232en_US
dc.identifier.doi10.1023/A:1021614018034-
dc.identifier.volume29en_US
dc.identifier.issue5-
dc.identifier.spage352en_US
dc.identifier.epage352en_US
dc.customcontrol.immutablesml 140918-

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