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Conference Paper: The effect of genotype and pedigree error on linkage analysis: Analysis of three asthma genome scans

TitleThe effect of genotype and pedigree error on linkage analysis: Analysis of three asthma genome scans
Authors
KeywordsAsthma
Genome scan
Genotype error
Linkage
Pedigree error
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841
Citation
Genetic Epidemiology, 2001, v. 21 SUPPL. 1, p. S117-S122 How to Cite?
AbstractThe effects of genotype and relationship errors on linkage results are evaluated in three of the Genetic Analysis Workshop 12 asthma genome scans. A number of errors are detected in the samples. While the evidence for linkage is not striking in any data set with or without error, in some cases the difference in test statistic could support different conclusions. The results provide empirical evidence for the predicted effects of genotype and relationship error and highlight the need for rigorous detection and elimination of data error in complex trait studies. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/143627
ISSN
2015 Impact Factor: 2.553
2015 SCImago Journal Rankings: 2.101
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorAbecasis, GRen_HK
dc.contributor.authorCookson, WOCen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorCardon, LRen_HK
dc.date.accessioned2011-12-16T08:08:16Z-
dc.date.available2011-12-16T08:08:16Z-
dc.date.issued2001en_HK
dc.identifier.citationGenetic Epidemiology, 2001, v. 21 SUPPL. 1, p. S117-S122en_HK
dc.identifier.issn0741-0395en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143627-
dc.description.abstractThe effects of genotype and relationship errors on linkage results are evaluated in three of the Genetic Analysis Workshop 12 asthma genome scans. A number of errors are detected in the samples. While the evidence for linkage is not striking in any data set with or without error, in some cases the difference in test statistic could support different conclusions. The results provide empirical evidence for the predicted effects of genotype and relationship error and highlight the need for rigorous detection and elimination of data error in complex trait studies. © 2001 Wiley-Liss, Inc.en_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841en_HK
dc.relation.ispartofGenetic Epidemiologyen_HK
dc.subjectAsthmaen_HK
dc.subjectGenome scanen_HK
dc.subjectGenotype erroren_HK
dc.subjectLinkageen_HK
dc.subjectPedigree erroren_HK
dc.titleThe effect of genotype and pedigree error on linkage analysis: Analysis of three asthma genome scansen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11793653-
dc.identifier.scopuseid_2-s2.0-0034797721en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034797721&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issueSUPPL. 1en_HK
dc.identifier.spageS117en_HK
dc.identifier.epageS122en_HK
dc.identifier.isiWOS:000171462700024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridAbecasis, GR=6604013253en_HK
dc.identifier.scopusauthoridCookson, WOC=35261536800en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridCardon, LR=7005082964en_HK

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