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Article: Significant linkage to migrane with aura on chromosome 11q24

TitleSignificant linkage to migrane with aura on chromosome 11q24
Authors
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2003, v. 12 n. 19, p. 2511-2517 How to Cite?
AbstractMigraine with aura (MA) is a prevalent neurological condition with strong evidence for a genetic basis. Familial hemiplegic migraine, a rare Mendelian form of MA, can be caused by mutations in the calcium channel gene, CACNA1A or in the ATP1A2 gene, a Na +/K + pump. Susceptibility genes for the more prevalent forms of migraine have yet to be identified despite several reports of linkage including loci on 4q24, 1q31, 19p13 and Xq24-28. We have undertaken a genome-wide screen of 43 Canadian families, segregating MA with families chosen for an apparent autosomal dominant pattern of transmission. Diagnosis was based upon International Headache Society Criteria. Parametric linkage analysis revealed a novel locus on 11q24 with a two-point LOD score of 4.2 and a multi-point parametric LOD score of 5.6. We did not find any support for linkage at previously reported loci. The lack of consensus amongst linkage studies, including this study, is probably an indication of the heterogeneity that is inherent for MA. Nevertheless, the finding of a highly significant locus with a LOD score of 5.6 is powerful evidence that a gene increasing susceptibility to MA resides on 11q24. Several candidate genes map to this region of the genome including a number of iion channel genes such as GRIK4, SCNB2, KCNJ5 and KCNJ1.
Persistent Identifierhttp://hdl.handle.net/10722/143623
ISSN
2015 Impact Factor: 5.985
2015 SCImago Journal Rankings: 4.288
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCader, ZMen_HK
dc.contributor.authorNobleTopham, Sen_HK
dc.contributor.authorDyment, DAen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorBrown, JDen_HK
dc.contributor.authorRice, GPAen_HK
dc.contributor.authorEbers, GCen_HK
dc.date.accessioned2011-12-16T08:08:13Z-
dc.date.available2011-12-16T08:08:13Z-
dc.date.issued2003en_HK
dc.identifier.citationHuman Molecular Genetics, 2003, v. 12 n. 19, p. 2511-2517en_HK
dc.identifier.issn0964-6906en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143623-
dc.description.abstractMigraine with aura (MA) is a prevalent neurological condition with strong evidence for a genetic basis. Familial hemiplegic migraine, a rare Mendelian form of MA, can be caused by mutations in the calcium channel gene, CACNA1A or in the ATP1A2 gene, a Na +/K + pump. Susceptibility genes for the more prevalent forms of migraine have yet to be identified despite several reports of linkage including loci on 4q24, 1q31, 19p13 and Xq24-28. We have undertaken a genome-wide screen of 43 Canadian families, segregating MA with families chosen for an apparent autosomal dominant pattern of transmission. Diagnosis was based upon International Headache Society Criteria. Parametric linkage analysis revealed a novel locus on 11q24 with a two-point LOD score of 4.2 and a multi-point parametric LOD score of 5.6. We did not find any support for linkage at previously reported loci. The lack of consensus amongst linkage studies, including this study, is probably an indication of the heterogeneity that is inherent for MA. Nevertheless, the finding of a highly significant locus with a LOD score of 5.6 is powerful evidence that a gene increasing susceptibility to MA resides on 11q24. Several candidate genes map to this region of the genome including a number of iion channel genes such as GRIK4, SCNB2, KCNJ5 and KCNJ1.en_HK
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Molecular Geneticsen_HK
dc.titleSignificant linkage to migrane with aura on chromosome 11q24en_HK
dc.typeArticleen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/hmg/ddg252en_HK
dc.identifier.pmid12915447-
dc.identifier.scopuseid_2-s2.0-0141730254en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141730254&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue19en_HK
dc.identifier.spage2511en_HK
dc.identifier.epage2517en_HK
dc.identifier.isiWOS:000185429800010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCader, ZM=6507078731en_HK
dc.identifier.scopusauthoridNobleTopham, S=6603179748en_HK
dc.identifier.scopusauthoridDyment, DA=6603145913en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridBrown, JD=7409453329en_HK
dc.identifier.scopusauthoridRice, GPA=35394940900en_HK
dc.identifier.scopusauthoridEbers, GC=15219142200en_HK

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