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Conference Paper: Association analysis in a variance components framework

TitleAssociation analysis in a variance components framework
Authors
KeywordsAssociation
Extended pedigree
QTL
TDT
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841
Citation
Genetic Epidemiology, 2001, v. 21 SUPPL. 1, p. S341-S346 How to Cite?
AbstractAssociation analyses conducted in a variance components framework can include information from all available individuals but remain unbiased in the presence of familiality or linkage. Models that include both linkage and association parameters provide different estimates of the effect of a single locus and can be used to distinguish causal polymorphisms from other types of variation. We examine some of these models and their properties in a blind analysis of the simulated Genetic Analysis Workshop 12 data sets. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/143619
ISSN
2015 Impact Factor: 2.553
2015 SCImago Journal Rankings: 2.101
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAbecasis, GRen_HK
dc.contributor.authorCardon, LRen_HK
dc.contributor.authorCookson, WOCen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorCherny, SSen_HK
dc.date.accessioned2011-12-16T08:08:09Z-
dc.date.available2011-12-16T08:08:09Z-
dc.date.issued2001en_HK
dc.identifier.citationGenetic Epidemiology, 2001, v. 21 SUPPL. 1, p. S341-S346en_HK
dc.identifier.issn0741-0395en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143619-
dc.description.abstractAssociation analyses conducted in a variance components framework can include information from all available individuals but remain unbiased in the presence of familiality or linkage. Models that include both linkage and association parameters provide different estimates of the effect of a single locus and can be used to distinguish causal polymorphisms from other types of variation. We examine some of these models and their properties in a blind analysis of the simulated Genetic Analysis Workshop 12 data sets. © 2001 Wiley-Liss, Inc.en_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841en_HK
dc.relation.ispartofGenetic Epidemiologyen_HK
dc.subjectAssociationen_HK
dc.subjectExtended pedigreeen_HK
dc.subjectQTLen_HK
dc.subjectTDTen_HK
dc.titleAssociation analysis in a variance components frameworken_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11793695-
dc.identifier.scopuseid_2-s2.0-0034797728en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034797728&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issueSUPPL. 1en_HK
dc.identifier.spageS341en_HK
dc.identifier.epageS346en_HK
dc.identifier.isiWOS:000171462700064-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAbecasis, GR=6604013253en_HK
dc.identifier.scopusauthoridCardon, LR=7005082964en_HK
dc.identifier.scopusauthoridCookson, WOC=35261536800en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK

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