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Article: Report of the committee on the genetic constitution of chromosomes 7, 8 and 9

TitleReport of the committee on the genetic constitution of chromosomes 7, 8 and 9
Authors
Issue Date1987
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CGR
Citation
Cytogenetics And Cell Genetics, 1987, v. 46 n. 1-4, p. 170-187 How to Cite?
AbstractThe principal assignment to human chromosome 7 since the last workshop has been the locus for cystic fibrosis (CF). The linkage of PON and CF was established at HGM8 (Eiberg et al. 1985) but the linkage group could not be assigned to a chromosome. The localization of CF and PON on chromosome 7 was demonstrated through linkage to a randomly isolated DNA segment, DOCRI-917 (now D7S15; Tsui et al. 1985), which was assigned to chromosome 7 (Knowlton et al. 1985). There are two new confirmed locus assignments on chromosome 8. Wilson et al. (1986) used human-Syrian hamster and human-Chinese hamster somatic cell hybrids to map the gene for beta-glycerol phosphatase (GPB). The enzyme catalyses the hydrolysis of beta-glycerol phosphate and their studies indicated that it may be a dimer. Wijnen et al. (HGM9) screened a panel of Chinese hamster - human hybrids and observed a discordance in segregation for GPB with every human chromosome except chromosome 8. Two other assigned loci GSR and PLAT co-segregated with GPB without exception. The results from one subclone suggests that GPB may be on the long arm of the chromosome (Wilson et al. 1986). The location of the glutamic-pyruvate transaminase locus (GPT) has finally been confirmed on chromosome 8 by linkage studies with TG and D8S19, with a lod for GPT-D8S19 greater than 3 at 22% recombination (O'Connell et al. HGM9; O'Connell, personal communication). Three new loci have been mapped to chromosome 9. Galactosyltransferase (GGTB2) was mapped by in situ hybridization studies (Duncan et al. 1986) using a cDNA probe and confirmed by Shaper et al. (1986) using a bovine probe. The gene maps to 9p21-p13. Two abstracts presented at this meeting map the fifth component of complement to the long arm of 9. Linkage between the ABO blood group and dopamine-beta-hydroxylase (DBH) has been suggested (Elston et al. 1979) and confirmed (Asamoah et al. 1987; Goldin et al. 1982). Data presented at the meeting assign DBH to 9q34 by in situ hybridization with a cDNA clone (Craig et al., personal communication) indicating that it is the structural DBH locus on 9. The regional assignment of delta-aminolevulinate dehydratase (ALAD, Wang et al. 1985) is confirmed by in situ hybridization of 9q34 (Potluri et al. 1987).
Persistent Identifierhttp://hdl.handle.net/10722/143613
ISSN
2003 Impact Factor: 1.162
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSpence, MAen_HK
dc.contributor.authorTsui, LCen_HK
dc.date.accessioned2011-12-15T06:56:00Z-
dc.date.available2011-12-15T06:56:00Z-
dc.date.issued1987en_HK
dc.identifier.citationCytogenetics And Cell Genetics, 1987, v. 46 n. 1-4, p. 170-187en_HK
dc.identifier.issn0301-0171en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143613-
dc.description.abstractThe principal assignment to human chromosome 7 since the last workshop has been the locus for cystic fibrosis (CF). The linkage of PON and CF was established at HGM8 (Eiberg et al. 1985) but the linkage group could not be assigned to a chromosome. The localization of CF and PON on chromosome 7 was demonstrated through linkage to a randomly isolated DNA segment, DOCRI-917 (now D7S15; Tsui et al. 1985), which was assigned to chromosome 7 (Knowlton et al. 1985). There are two new confirmed locus assignments on chromosome 8. Wilson et al. (1986) used human-Syrian hamster and human-Chinese hamster somatic cell hybrids to map the gene for beta-glycerol phosphatase (GPB). The enzyme catalyses the hydrolysis of beta-glycerol phosphate and their studies indicated that it may be a dimer. Wijnen et al. (HGM9) screened a panel of Chinese hamster - human hybrids and observed a discordance in segregation for GPB with every human chromosome except chromosome 8. Two other assigned loci GSR and PLAT co-segregated with GPB without exception. The results from one subclone suggests that GPB may be on the long arm of the chromosome (Wilson et al. 1986). The location of the glutamic-pyruvate transaminase locus (GPT) has finally been confirmed on chromosome 8 by linkage studies with TG and D8S19, with a lod for GPT-D8S19 greater than 3 at 22% recombination (O'Connell et al. HGM9; O'Connell, personal communication). Three new loci have been mapped to chromosome 9. Galactosyltransferase (GGTB2) was mapped by in situ hybridization studies (Duncan et al. 1986) using a cDNA probe and confirmed by Shaper et al. (1986) using a bovine probe. The gene maps to 9p21-p13. Two abstracts presented at this meeting map the fifth component of complement to the long arm of 9. Linkage between the ABO blood group and dopamine-beta-hydroxylase (DBH) has been suggested (Elston et al. 1979) and confirmed (Asamoah et al. 1987; Goldin et al. 1982). Data presented at the meeting assign DBH to 9q34 by in situ hybridization with a cDNA clone (Craig et al., personal communication) indicating that it is the structural DBH locus on 9. The regional assignment of delta-aminolevulinate dehydratase (ALAD, Wang et al. 1985) is confirmed by in situ hybridization of 9q34 (Potluri et al. 1987).en_HK
dc.languageeng-
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CGRen_HK
dc.relation.ispartofCytogenetics and Cell Geneticsen_HK
dc.rightsCytogenetics and Cell Genetics. Copyright © S Karger AG.-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Human, Pair 7-
dc.subject.meshChromosomes, Human, Pair 8-
dc.subject.meshChromosomes, Human, Pair 9-
dc.subject.meshGenetic Markers-
dc.titleReport of the committee on the genetic constitution of chromosomes 7, 8 and 9en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-0171&volume=46&issue=1-4&spage=170&epage=187&date=1987&atitle=Report+of+the+committee+on+the+genetic+constitution+of+chromosomes+7,+8+and+9-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000132476-
dc.identifier.pmid3507273en_HK
dc.identifier.scopuseid_2-s2.0-0023630772en_HK
dc.identifier.volume46en_HK
dc.identifier.issue1-4en_HK
dc.identifier.spage170en_HK
dc.identifier.epage187en_HK
dc.identifier.isiWOS:A1987N171900007-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridSpence, MA=7103007607en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK

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