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Article: Myasthenia gravis in Hong Kong Chinese. I. Epidemiology and adult disease

TitleMyasthenia gravis in Hong Kong Chinese. I. Epidemiology and adult disease
Authors
Keywordsadult-onset
Chinese
epidemiology
myasthenia gravis
Issue Date1992
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANE
Citation
Acta Neurologica Scandinavica, 1992, v. 86 n. 2, p. 113-119 How to Cite?
AbstractA territory-wide study of myasthenia gravis (MG) was conducted in Hong Kong. Two hundred and sixty-two Chinese patients (159 adult and 103 paediatric onset) were identified, corresponding to a point prevalence and period prevalence of 53.5 and 62.2 per million respectively, and an average annual incidence of 4.0 per million population. Nine patients died, 7 from MG, giving a case fatality rate of 0.027. Female predominance was present in the whole group of patients (female to male ratio 1.6:1) and in those with adult disease (ratio 2.1:1), but not in those with onset in childhood (ration 1.1:1). Onset of disease was most common in the first 3 decades of life, and became less common in subsequent decades. Juvenile onset MG occurred in 39.3% of patients and restricted ocular MG in 47.9%. Familial occurrence was found in 5 patients. In the 159 adult onset patients, ocular disease was most common (32.7%), followed by mild generalised (29.6%), moderately severe generalised (24.5%), fulminating (11.9%) and late severe disease (1.3%). The mean age of onset of symptoms was 36.7 years. The symptomatology was similar to that of Caucasoid populations. Autoimmune thyroid disease was the commonest associated disease, and the incidence of thymoma among thymic abnormalities was high at 38%.
Persistent Identifierhttp://hdl.handle.net/10722/143600
ISSN
2015 Impact Factor: 2.559
2015 SCImago Journal Rankings: 1.203
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, YLen_HK
dc.contributor.authorHawkins, BRen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorWong, Ven_HK
dc.contributor.authorWoo, Een_HK
dc.date.accessioned2011-12-12T03:52:13Z-
dc.date.available2011-12-12T03:52:13Z-
dc.date.issued1992en_HK
dc.identifier.citationActa Neurologica Scandinavica, 1992, v. 86 n. 2, p. 113-119en_HK
dc.identifier.issn0001-6314en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143600-
dc.description.abstractA territory-wide study of myasthenia gravis (MG) was conducted in Hong Kong. Two hundred and sixty-two Chinese patients (159 adult and 103 paediatric onset) were identified, corresponding to a point prevalence and period prevalence of 53.5 and 62.2 per million respectively, and an average annual incidence of 4.0 per million population. Nine patients died, 7 from MG, giving a case fatality rate of 0.027. Female predominance was present in the whole group of patients (female to male ratio 1.6:1) and in those with adult disease (ratio 2.1:1), but not in those with onset in childhood (ration 1.1:1). Onset of disease was most common in the first 3 decades of life, and became less common in subsequent decades. Juvenile onset MG occurred in 39.3% of patients and restricted ocular MG in 47.9%. Familial occurrence was found in 5 patients. In the 159 adult onset patients, ocular disease was most common (32.7%), followed by mild generalised (29.6%), moderately severe generalised (24.5%), fulminating (11.9%) and late severe disease (1.3%). The mean age of onset of symptoms was 36.7 years. The symptomatology was similar to that of Caucasoid populations. Autoimmune thyroid disease was the commonest associated disease, and the incidence of thymoma among thymic abnormalities was high at 38%.en_HK
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANEen_HK
dc.relation.ispartofActa Neurologica Scandinavicaen_HK
dc.subjectadult-onseten_HK
dc.subjectChineseen_HK
dc.subjectepidemiologyen_HK
dc.subjectmyasthenia gravisen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshEthnic Groups/*statistics & numerical dataen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequency/geneticsen_US
dc.subject.meshHLA-B Antigens/geneticsen_US
dc.subject.meshHong Kong/epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyasthenia Gravis/diagnosis/*epidemiology/geneticsen_US
dc.subject.meshNeurologic Examinationen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThymoma/diagnosis/epidemiology/geneticsen_US
dc.subject.meshThymus Neoplasms/diagnosis/epidemiology/geneticsen_US
dc.titleMyasthenia gravis in Hong Kong Chinese. I. Epidemiology and adult diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid1414218-
dc.identifier.scopuseid_2-s2.0-0026732855en_HK
dc.identifier.volume86en_HK
dc.identifier.issue2en_HK
dc.identifier.spage113en_HK
dc.identifier.epage119en_HK
dc.identifier.isiWOS:A1992JL20500001-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridYu, YL=8094845300en_HK
dc.identifier.scopusauthoridHawkins, BR=35944486200en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK
dc.identifier.scopusauthoridWoo, E=7103371219en_HK

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