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Article: Neurodevelopmental profile of Down syndrome in Chinese children

TitleNeurodevelopmental profile of Down syndrome in Chinese children
Authors
KeywordsDevelopmental quotient
Down syndrome
Epilepsy
Hearing impairment
Neurodevelopmental profile
Ocular features
Issue Date1996
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPC
Citation
Journal Of Paediatrics And Child Health, 1996, v. 32 n. 2, p. 153-157 How to Cite?
AbstractObjective: To give an overall appraisal of the clinical features of Down syndrome (DS) in Chinese children with emphasis on the neurodevelopmental outcome, and to compare the related complications with that of other races. Methodology: The records of 124 Chinese children with DS assessed at the Child Assessment Centre of the University Department of Paediatrics in the Duchess of Kent Children's Hospital from 1985 to 1993 were reviewed. Results: Thirty-one per cent of patients had microcephaly. Eighty-five per cent (33/39) when assessed in the first year of life had a developmental quotient (DQ) above 50 but only 29% (2/7) had DQ above 50 when assessed after the age of 5. Only two patients (1.6%) had epilepsy: infantile spasms (1) and Lennox-Gastaut syndrome (1). Hearing impairment was found in 45% of children with mild conductive hearing impairment being the most common. Conclusions: Chinese children with DS, when compared with other races, were similarly intellectually disabled, but were less likely to develop epilepsy.
Persistent Identifierhttp://hdl.handle.net/10722/143589
ISSN
2015 Impact Factor: 1.477
2015 SCImago Journal Rankings: 0.692
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, KLen_HK
dc.contributor.authorWong, Ven_HK
dc.date.accessioned2011-12-12T03:52:09Z-
dc.date.available2011-12-12T03:52:09Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Paediatrics And Child Health, 1996, v. 32 n. 2, p. 153-157en_HK
dc.identifier.issn1034-4810en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143589-
dc.description.abstractObjective: To give an overall appraisal of the clinical features of Down syndrome (DS) in Chinese children with emphasis on the neurodevelopmental outcome, and to compare the related complications with that of other races. Methodology: The records of 124 Chinese children with DS assessed at the Child Assessment Centre of the University Department of Paediatrics in the Duchess of Kent Children's Hospital from 1985 to 1993 were reviewed. Results: Thirty-one per cent of patients had microcephaly. Eighty-five per cent (33/39) when assessed in the first year of life had a developmental quotient (DQ) above 50 but only 29% (2/7) had DQ above 50 when assessed after the age of 5. Only two patients (1.6%) had epilepsy: infantile spasms (1) and Lennox-Gastaut syndrome (1). Hearing impairment was found in 45% of children with mild conductive hearing impairment being the most common. Conclusions: Chinese children with DS, when compared with other races, were similarly intellectually disabled, but were less likely to develop epilepsy.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JPCen_HK
dc.relation.ispartofJournal of Paediatrics and Child Healthen_HK
dc.subjectDevelopmental quotienten_HK
dc.subjectDown syndromeen_HK
dc.subjectEpilepsyen_HK
dc.subjectHearing impairmenten_HK
dc.subjectNeurodevelopmental profileen_HK
dc.subjectOcular featuresen_HK
dc.subject.meshAdolescenten_US
dc.subject.mesh*Asian Continental Ancestry Groupen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChina/ethnologyen_US
dc.subject.meshDown Syndrome/*complications/ethnology/geneticsen_US
dc.subject.meshEpilepsy/*etiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHearing Disorders/*etiologyen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMental Retardation/*etiologyen_US
dc.subject.meshMicrocephaly/*etiologyen_US
dc.titleNeurodevelopmental profile of Down syndrome in Chinese childrenen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9156526-
dc.identifier.scopuseid_2-s2.0-0030004199en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030004199&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue2en_HK
dc.identifier.spage153en_HK
dc.identifier.epage157en_HK
dc.identifier.isiWOS:A1996UL94400014-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridKwong, KL=7103035460en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK

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