A neurophysiological study in children with Miller Fisher Syndrome and Guillain-Barre syndrome

Abstract

Serial neurophysiological studies were performed in four children with Miller Fisher syndrome (MFS) (n = 2) and Guillain-Barre syndrome (GBS) (n = 2) to delineate the extent of subclinical neurological involvement. Nerve conduction study showed radiculoneuropathy in both MFS and GBS. Somatosensory evoked potential study showed evidence of peripheral and central involvement of the neural pathway in both. Brainstem auditory evoked potential study showed peripheral auditory and brainstem involvement in MFS but was normal in GBS. This study provides neurophysiological evidence that MFS and GBS might possibly belong to the clinical spectrum of encephalo-myelo-radiculo-neuropathy (EMRN) with different extent of central and peripheral involvement.