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Article: Electro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator

TitleElectro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator
Authors
KeywordsCystathionine-β-synthase
Electro-acupuncture
Hydrogen sulfide
Hypoxic-ischemic brain-damage
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2010, v. 485 n. 1, p. 74-78 How to Cite?
AbstractWe investigated whether hydrogen sulfide (H 2S) may be a mediator of electro-acupuncture (EA) stimulation treatment for hypoxic-ischemic brain-damage (HIBD). We studied a HIBD 7-day-old rat model with 4 types of treatments: (1) 14 sessions of EA; (2) hydroxylamine (HA), an inhibitor of cystathionine-β-synthase (CBS), the key enzyme of H 2S generation; (3) both EA and HA; or (4) no treatment. Sham-treated rats with or without EA were also studied. Regional cerebral blood flow (rCBF) was monitored before, during and after EA at different periods of treatment (d1, 7 and 14 sessions). We evaluated motor function, H 2S levels and CBS expression in the cerebral cortex and prepared cerebral pathomorphological images after 14 sessions of treatment. EA stimulation could increase local blood circulation and improve motor function in HIBD rats. HIBD significantly increased H 2S levels of brain tissue as compared with sham treatment, and EA treatment could decrease the H 2S generation. Rats with HIBD receiving both EA and HA therapy showed greatly recovered motor function and brain morphology. H 2S might be a mediator of EA treatment of HIBD in rats. © 2010 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/143560
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
Funding AgencyGrant Number
International Cooperation of Science and Technique Foundation of Beijing2007G05
Funding Information:

The study was approved by the Animal Research Committee of China, PLA General Hospital (Beijing). The research was sponsored by the International Cooperation of Science and Technique Foundation of Beijing (2007G05).

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorZou, LPen_HK
dc.contributor.authorDu, JBen_HK
dc.contributor.authorWong, Ven_HK
dc.date.accessioned2011-12-12T03:51:54Z-
dc.date.available2011-12-12T03:51:54Z-
dc.date.issued2010en_HK
dc.identifier.citationNeuroscience Letters, 2010, v. 485 n. 1, p. 74-78en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143560-
dc.description.abstractWe investigated whether hydrogen sulfide (H 2S) may be a mediator of electro-acupuncture (EA) stimulation treatment for hypoxic-ischemic brain-damage (HIBD). We studied a HIBD 7-day-old rat model with 4 types of treatments: (1) 14 sessions of EA; (2) hydroxylamine (HA), an inhibitor of cystathionine-β-synthase (CBS), the key enzyme of H 2S generation; (3) both EA and HA; or (4) no treatment. Sham-treated rats with or without EA were also studied. Regional cerebral blood flow (rCBF) was monitored before, during and after EA at different periods of treatment (d1, 7 and 14 sessions). We evaluated motor function, H 2S levels and CBS expression in the cerebral cortex and prepared cerebral pathomorphological images after 14 sessions of treatment. EA stimulation could increase local blood circulation and improve motor function in HIBD rats. HIBD significantly increased H 2S levels of brain tissue as compared with sham treatment, and EA treatment could decrease the H 2S generation. Rats with HIBD receiving both EA and HA therapy showed greatly recovered motor function and brain morphology. H 2S might be a mediator of EA treatment of HIBD in rats. © 2010 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.subjectCystathionine-β-synthaseen_HK
dc.subjectElectro-acupunctureen_HK
dc.subjectHydrogen sulfideen_HK
dc.subjectHypoxic-ischemic brain-damageen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshCerebral Cortex/drug effects/metabolism/pathologyen_US
dc.subject.meshCerebrovascular Circulationen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshCystathionine beta-Synthase/antagonists & inhibitorsen_US
dc.subject.mesh*Electroacupunctureen_US
dc.subject.meshHydrogen Sulfide/*metabolismen_US
dc.subject.meshHydroxylamine/therapeutic useen_US
dc.subject.meshHypoxia-Ischemia, Brain/metabolism/physiopathology/*prevention & controlen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleElectro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediatoren_HK
dc.typeArticleen_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neulet.2010.08.068en_HK
dc.identifier.pmid20813156en_HK
dc.identifier.scopuseid_2-s2.0-77957233842en_HK
dc.identifier.hkuros183159-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957233842&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume485en_HK
dc.identifier.issue1en_HK
dc.identifier.spage74en_HK
dc.identifier.epage78en_HK
dc.identifier.isiWOS:000283266700015-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLiu, Y=36071871200en_HK
dc.identifier.scopusauthoridZou, LP=8124318700en_HK
dc.identifier.scopusauthoridDu, JB=7402574838en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK
dc.identifier.citeulike7820037-

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