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Article: Spectrum of anticonvulsant hypersensitivity syndrome: Controversy of treatment

TitleSpectrum of anticonvulsant hypersensitivity syndrome: Controversy of treatment
Authors
Issue Date2004
PublisherSage Publications, Inc.. The Journal's web site is located at http://jcn.sagepub.com
Citation
Journal Of Child Neurology, 2004, v. 19 n. 8, p. 619-623 How to Cite?
AbstractAn 18-month-old girl presented with a maculopapular rash 10 days after carbamazepine treatment. Initially, she was suspected of having a viral rash owing to associated fever. She deteriorated rapidly and was suspected of having anticonvulsant hypersensitivity syndrome or Stevens-Johnson syndrome. She developed features compatible with toxic epidermal necrolysis rapidly over 24 to 36 hours. Carbamazepine was then stopped. She responded immediately to high-dose intravenous pulse methylprednisone treatment. We discuss the controversy in the management of anticonvulsant hypersensitivity syndrome, toxic epidermal necrolysis, or Stevens-Johnson syndrome with high-dose corticosteroids, intravenous immunoglobulin, and antibiotics.
Persistent Identifierhttp://hdl.handle.net/10722/143554
ISSN
2015 Impact Factor: 1.434
2015 SCImago Journal Rankings: 0.694
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, WCen_HK
dc.contributor.authorLeung, JLSen_HK
dc.contributor.authorFung, CWen_HK
dc.contributor.authorChung, BHYen_HK
dc.contributor.authorWong, Ven_HK
dc.date.accessioned2011-12-12T03:51:50Z-
dc.date.available2011-12-12T03:51:50Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Child Neurology, 2004, v. 19 n. 8, p. 619-623en_HK
dc.identifier.issn0883-0738en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143554-
dc.description.abstractAn 18-month-old girl presented with a maculopapular rash 10 days after carbamazepine treatment. Initially, she was suspected of having a viral rash owing to associated fever. She deteriorated rapidly and was suspected of having anticonvulsant hypersensitivity syndrome or Stevens-Johnson syndrome. She developed features compatible with toxic epidermal necrolysis rapidly over 24 to 36 hours. Carbamazepine was then stopped. She responded immediately to high-dose intravenous pulse methylprednisone treatment. We discuss the controversy in the management of anticonvulsant hypersensitivity syndrome, toxic epidermal necrolysis, or Stevens-Johnson syndrome with high-dose corticosteroids, intravenous immunoglobulin, and antibiotics.en_HK
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://jcn.sagepub.comen_HK
dc.relation.ispartofJournal of Child Neurologyen_HK
dc.subject.meshAnticonvulsants/*adverse effectsen_US
dc.subject.meshCarbamazepine/*adverse effectsen_US
dc.subject.meshEpidermal Necrolysis, Toxic/*drug therapy/*etiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucocorticoids/*administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfusions, Intravenousen_US
dc.subject.meshMethylprednisolone/*administration & dosageen_US
dc.subject.meshPulse Therapy, Drugen_US
dc.subject.meshSyndromeen_US
dc.titleSpectrum of anticonvulsant hypersensitivity syndrome: Controversy of treatmenten_HK
dc.typeArticleen_HK
dc.identifier.emailChung, BHY:bhychung@hku.hken_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityChung, BHY=rp00473en_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15605473-
dc.identifier.scopuseid_2-s2.0-10444242583en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10444242583&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue8en_HK
dc.identifier.spage619en_HK
dc.identifier.epage623en_HK
dc.identifier.isiWOS:000228707600010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, WC=8318696100en_HK
dc.identifier.scopusauthoridLeung, JLS=7202180415en_HK
dc.identifier.scopusauthoridFung, CW=7102443761en_HK
dc.identifier.scopusauthoridChung, BHY=7203043997en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK

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