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Article: Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy

TitleFailure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy
Authors
KeywordsChinese
Epilepsy
Febrile seizures
SCN1A
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.epilepsia.com/
Citation
Epilepsia, 2010, v. 51 n. 9, p. 1878-1881 How to Cite?
AbstractA recent study in Caucasians found an association between the single nucleotide polymorphism (SNP) of SCN1A, IVS5N +5 G>A (rs3812718), and febrile seizures (FS). We examined whether this and other tagging SNPs of SCN1A were associated with an increased risk of FS in Han Chinese. A total of 728 Han Chinese patients with focal epilepsy were recruited: 97 had a history of FS (58% male, mean age 35 ± 12 years) and 631 did not (50% male, mean age 40 ± 15 years). Genotyping was performed for IVS5N +5 G>A and seven other tagging SNPs selected from the HapMap database. Genotyping was also performed in 848 ethnically matched population controls (50% male, mean age 37 ± 17 years). There was no statistically significant difference in either allele or genotype frequency of any of the SNPs studied between epilepsy patients with and without FS, and between epilepsy patients with FS and controls. The results do not suggest that SCN1A SNPs are susceptibility factors for FS in Han Chinese. © 2010 International League Against Epilepsy.
Persistent Identifierhttp://hdl.handle.net/10722/143538
ISSN
2015 Impact Factor: 4.706
2015 SCImago Journal Rankings: 2.579
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of the Hong Kong Special Administrative Region, ChinaCUHK4466/06M
Funding Information:

Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. CUHK4466/06M). We would like to thank Drs. Brian Tomlinson and Gary Wong, both of the Chinese University of Hong Kong, for providing some of the DNA samples of the population controls. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. None of the authors has any confl ict of interest to disclose.

References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Cen_HK
dc.contributor.authorWong, Ven_HK
dc.contributor.authorNg, PWen_HK
dc.contributor.authorLui, CHTen_HK
dc.contributor.authorSin, NCen_HK
dc.contributor.authorWong, KSen_HK
dc.contributor.authorBaum, Len_HK
dc.contributor.authorKwan, Pen_HK
dc.date.accessioned2011-12-12T03:51:37Z-
dc.date.available2011-12-12T03:51:37Z-
dc.date.issued2010en_HK
dc.identifier.citationEpilepsia, 2010, v. 51 n. 9, p. 1878-1881en_HK
dc.identifier.issn0013-9580en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143538-
dc.description.abstractA recent study in Caucasians found an association between the single nucleotide polymorphism (SNP) of SCN1A, IVS5N +5 G>A (rs3812718), and febrile seizures (FS). We examined whether this and other tagging SNPs of SCN1A were associated with an increased risk of FS in Han Chinese. A total of 728 Han Chinese patients with focal epilepsy were recruited: 97 had a history of FS (58% male, mean age 35 ± 12 years) and 631 did not (50% male, mean age 40 ± 15 years). Genotyping was performed for IVS5N +5 G>A and seven other tagging SNPs selected from the HapMap database. Genotyping was also performed in 848 ethnically matched population controls (50% male, mean age 37 ± 17 years). There was no statistically significant difference in either allele or genotype frequency of any of the SNPs studied between epilepsy patients with and without FS, and between epilepsy patients with FS and controls. The results do not suggest that SCN1A SNPs are susceptibility factors for FS in Han Chinese. © 2010 International League Against Epilepsy.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.epilepsia.com/en_HK
dc.relation.ispartofEpilepsiaen_HK
dc.subjectChineseen_HK
dc.subjectEpilepsyen_HK
dc.subjectFebrile seizuresen_HK
dc.subjectSCN1Aen_HK
dc.titleFailure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsyen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1528-1167.2010.02587.xen_HK
dc.identifier.pmid20477842-
dc.identifier.scopuseid_2-s2.0-77956335164en_HK
dc.identifier.hkuros183158-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956335164&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1878en_HK
dc.identifier.epage1881en_HK
dc.identifier.isiWOS:000281554800030-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, C=36605668200en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK
dc.identifier.scopusauthoridNg, PW=7201376949en_HK
dc.identifier.scopusauthoridLui, CHT=36943011700en_HK
dc.identifier.scopusauthoridSin, NC=6602256513en_HK
dc.identifier.scopusauthoridWong, KS=7404759405en_HK
dc.identifier.scopusauthoridBaum, L=7103310839en_HK
dc.identifier.scopusauthoridKwan, P=7004369601en_HK
dc.identifier.citeulike7782435-

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