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Article: Meta-analysis of association between a catechol-O-methyltransferase gene polymorphism and attention deficit hyperactivity disorder

TitleMeta-analysis of association between a catechol-O-methyltransferase gene polymorphism and attention deficit hyperactivity disorder
Authors
KeywordsAttention deficit hyperactivity disorder (ADHD)
Catechol-O- methyltransferase (COMT)
Meta-analysis
Polymorphism
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244
Citation
Behavior Genetics, 2006, v. 36 n. 5, p. 651-659 How to Cite?
AbstractThere have been conflicting reports on the association between the Val158/108Met polymorphism of the catechol-O-methyltransferase (COMT) gene and attention deficit hyperactivity disorder (ADHD). Therefore we would like to perform a meta-analysis of previous studies to assess the overall magnitude and significance of the association. Family-based and case-control studies of the association between the COMT gene polymorphism and ADHD were searched systematically and comprehensively. Odds ratios (OR) of association were pooled by the fixed effects model if no significant heterogeneity was present among different studies. Subgroup analysis by gender and ADHD subtypes were also performed. Eleven family-based and two case-control studies were identified. After pooling the results, no significant association between the COMT Val158/108Met polymorphism and ADHD was found (OR 0.99 (95% CI: 0.88-1.12), P = 0.87). There was also no significant association when the results were stratified by gender or ADHD subtype. There was no significant statistical heterogeneity (χ2 = 12.27, P = 0.2) although clinical heterogeneity was present in the studies, especially the ethnicity of subjects. Sensitivity analysis demonstrated absence of undue influence of any single study. Standard regression analysis showed no significant publication bias. We concluded that no significant association was present between the most common COMT gene polymorphism and ADHD. Further studies should employ larger sample size in more homogeneous subjects. Further investigations in moderator variables and gene-gene and gene-environment interactions are also warranted. © Springer Science+Business Media, Inc. 2006.
Persistent Identifierhttp://hdl.handle.net/10722/143534
ISSN
2015 Impact Factor: 3.268
2015 SCImago Journal Rankings: 1.457
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, DKLen_HK
dc.contributor.authorWong, Ven_HK
dc.date.accessioned2011-12-12T03:51:35Z-
dc.date.available2011-12-12T03:51:35Z-
dc.date.issued2006en_HK
dc.identifier.citationBehavior Genetics, 2006, v. 36 n. 5, p. 651-659en_HK
dc.identifier.issn0001-8244en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143534-
dc.description.abstractThere have been conflicting reports on the association between the Val158/108Met polymorphism of the catechol-O-methyltransferase (COMT) gene and attention deficit hyperactivity disorder (ADHD). Therefore we would like to perform a meta-analysis of previous studies to assess the overall magnitude and significance of the association. Family-based and case-control studies of the association between the COMT gene polymorphism and ADHD were searched systematically and comprehensively. Odds ratios (OR) of association were pooled by the fixed effects model if no significant heterogeneity was present among different studies. Subgroup analysis by gender and ADHD subtypes were also performed. Eleven family-based and two case-control studies were identified. After pooling the results, no significant association between the COMT Val158/108Met polymorphism and ADHD was found (OR 0.99 (95% CI: 0.88-1.12), P = 0.87). There was also no significant association when the results were stratified by gender or ADHD subtype. There was no significant statistical heterogeneity (χ2 = 12.27, P = 0.2) although clinical heterogeneity was present in the studies, especially the ethnicity of subjects. Sensitivity analysis demonstrated absence of undue influence of any single study. Standard regression analysis showed no significant publication bias. We concluded that no significant association was present between the most common COMT gene polymorphism and ADHD. Further studies should employ larger sample size in more homogeneous subjects. Further investigations in moderator variables and gene-gene and gene-environment interactions are also warranted. © Springer Science+Business Media, Inc. 2006.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0001-8244en_HK
dc.relation.ispartofBehavior Geneticsen_HK
dc.subjectAttention deficit hyperactivity disorder (ADHD)en_HK
dc.subjectCatechol-O- methyltransferase (COMT)en_HK
dc.subjectMeta-analysisen_HK
dc.subjectPolymorphismen_HK
dc.subject.meshAmino Acid Substitutionen_US
dc.subject.meshAttention Deficit Disorder with Hyperactivity/enzymology/*geneticsen_US
dc.subject.meshCatechol O-Methyltransferase/*geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMethionineen_US
dc.subject.meshOdds Ratioen_US
dc.subject.mesh*Polymorphism, Geneticen_US
dc.subject.meshValineen_US
dc.titleMeta-analysis of association between a catechol-O-methyltransferase gene polymorphism and attention deficit hyperactivity disorderen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10519-006-9076-5en_HK
dc.identifier.pmid16676224-
dc.identifier.scopuseid_2-s2.0-33746895813en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746895813&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue5en_HK
dc.identifier.spage651en_HK
dc.identifier.epage659en_HK
dc.identifier.isiWOS:000239589700003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheuk, DKL=8705936100en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK

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