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Article: Acupuncture for epilepsy

TitleAcupuncture for epilepsy
Authors
KeywordsAcupuncture therapy [*methods]
Child
Drugs, Chinese herbal [therapeutic use]
Epilepsy [*therapy]
Humans
Randomized controlled trials
Treatment outcome
Issue Date2006
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.mrw.interscience.wiley.com/cochrane/cochrane_clsysrev_articles_fs.html
Citation
Cochrane Database Of Systematic Reviews, 2006 n. 2 How to Cite?
AbstractBackground: Seizures are poorly controlled in many people with epilepsy despite adequate current antiepileptic treatments. There is increasing interest in alternative therapies such as acupuncture; however, it remains unclear whether the existing evidence is rigorous enough to support the use of acupuncture. Objectives: To determine the effectiveness and safety of acupuncture in people with epilepsy. Search strategy: We searched the Cochrane Epilepsy Group's Specialized Register (June 2005) and the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 3, 2005). We also searched MEDLINE, EMBASE, CINAHL, AMED, TCMLARS, China Biological Medicine Database, Chinese Acupuncture Trials Register, National Center for Complementary and Alternative Medicine, and National Institute of Health Clinical Trials Database from inception to June 2005. Reference lists from relevant trials were reviewed. No language restrictions were imposed. Selection criteria: Randomised controlled trials evaluating any form of acupuncture involving people of any age with any type of epilepsy were included. Trials included were those comparing acupuncture with placebo, shamor no treatment; or comparing acupuncture plus other treatments with the same other treatments. Trials that only compared different acupuncture methods or compared acupuncture alone with other treatments were excluded. Data collection and analysis: Two review authors independently extracted trial data and assessed trial quality using the Jadad score. Relative risk (RR) was used for binary data and weighted mean difference for continuous data, and 95% confidence intervals are given. Where possible, analyses were by intention to treat. Main results: Three small trials of varying methodological quality and with short follow up met the inclusion criteria. Two studied children in China and one studied adults in Norway. The two Chinese studies compared acupuncture plus Chinese herbs with Chinese herbs alone while the Norwegian study compared acupuncture with sham acupuncture. The two Chinese studies found that more children treated with acupuncture achieved 75% or greater reduction in seizure frequency (RR 1.52, 95% CI 1.12 to 2.05) and seizure duration (RR 2.38, 95% CI 1.13 to 5) with a significant 50% or greater reduction in seizure duration (RR 1.36, 95% CI 1.07 to 1.73). However, the two trials were of low quality without adequate description of randomisation method, concealment of randomisation or blinding. On the other hand, the higher quality Norwegian trial found that acupuncture did not improve the mean seizure frequency, seizure-free weeks, or quality of life in adults. Authors' conclusions: The current evidence does not support acupuncture as a treatment for epilepsy. Much larger high quality clinical trials employing appropriate controls are needed. Copyright © 2006 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/143533
ISSN
2014 Impact Factor: 6.035
2015 SCImago Journal Rankings: 2.366
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, DKLen_HK
dc.contributor.authorWong, Ven_HK
dc.date.accessioned2011-12-12T03:51:34Z-
dc.date.available2011-12-12T03:51:34Z-
dc.date.issued2006en_HK
dc.identifier.citationCochrane Database Of Systematic Reviews, 2006 n. 2en_HK
dc.identifier.issn1469-493Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/143533-
dc.description.abstractBackground: Seizures are poorly controlled in many people with epilepsy despite adequate current antiepileptic treatments. There is increasing interest in alternative therapies such as acupuncture; however, it remains unclear whether the existing evidence is rigorous enough to support the use of acupuncture. Objectives: To determine the effectiveness and safety of acupuncture in people with epilepsy. Search strategy: We searched the Cochrane Epilepsy Group's Specialized Register (June 2005) and the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 3, 2005). We also searched MEDLINE, EMBASE, CINAHL, AMED, TCMLARS, China Biological Medicine Database, Chinese Acupuncture Trials Register, National Center for Complementary and Alternative Medicine, and National Institute of Health Clinical Trials Database from inception to June 2005. Reference lists from relevant trials were reviewed. No language restrictions were imposed. Selection criteria: Randomised controlled trials evaluating any form of acupuncture involving people of any age with any type of epilepsy were included. Trials included were those comparing acupuncture with placebo, shamor no treatment; or comparing acupuncture plus other treatments with the same other treatments. Trials that only compared different acupuncture methods or compared acupuncture alone with other treatments were excluded. Data collection and analysis: Two review authors independently extracted trial data and assessed trial quality using the Jadad score. Relative risk (RR) was used for binary data and weighted mean difference for continuous data, and 95% confidence intervals are given. Where possible, analyses were by intention to treat. Main results: Three small trials of varying methodological quality and with short follow up met the inclusion criteria. Two studied children in China and one studied adults in Norway. The two Chinese studies compared acupuncture plus Chinese herbs with Chinese herbs alone while the Norwegian study compared acupuncture with sham acupuncture. The two Chinese studies found that more children treated with acupuncture achieved 75% or greater reduction in seizure frequency (RR 1.52, 95% CI 1.12 to 2.05) and seizure duration (RR 2.38, 95% CI 1.13 to 5) with a significant 50% or greater reduction in seizure duration (RR 1.36, 95% CI 1.07 to 1.73). However, the two trials were of low quality without adequate description of randomisation method, concealment of randomisation or blinding. On the other hand, the higher quality Norwegian trial found that acupuncture did not improve the mean seizure frequency, seizure-free weeks, or quality of life in adults. Authors' conclusions: The current evidence does not support acupuncture as a treatment for epilepsy. Much larger high quality clinical trials employing appropriate controls are needed. Copyright © 2006 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.mrw.interscience.wiley.com/cochrane/cochrane_clsysrev_articles_fs.htmlen_HK
dc.relation.ispartofCochrane Database of Systematic Reviewsen_HK
dc.subjectAcupuncture therapy [*methods]en_HK
dc.subjectChilden_HK
dc.subjectDrugs, Chinese herbal [therapeutic use]en_HK
dc.subjectEpilepsy [*therapy]en_HK
dc.subjectHumansen_HK
dc.subjectRandomized controlled trialsen_HK
dc.subjectTreatment outcomeen_HK
dc.subject.meshAcupuncture Therapy/*methodsen_US
dc.subject.meshChilden_US
dc.subject.meshDrugs, Chinese Herbal/therapeutic useen_US
dc.subject.meshEpilepsy/*therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshRandomized Controlled Trials as Topicen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleAcupuncture for epilepsyen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/14651858.CD005062.pub2en_HK
dc.identifier.pmid16625622en_US
dc.identifier.scopuseid_2-s2.0-37649027054en_HK
dc.identifier.hkuros115513-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37649027054&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.issue2en_HK
dc.identifier.spageCD005062en_US
dc.identifier.epageCD005062en_US
dc.identifier.eissn1469-493X-
dc.identifier.isiWOS:000236932100050-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheuk, DKL=8705936100en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK

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