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Article: Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese

TitleAssociation between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese
Authors
KeywordsABCB1
Antiepileptic drugs
Chinese
Drug resistance
Drug transporters
Epilepsy
Genetic polymorphisms
MDR1
P-glycoprotein
Pharmacogenetics
Issue Date2007
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yebeh
Citation
Epilepsy And Behavior, 2007, v. 11 n. 1, p. 112-117 How to Cite?
AbstractThere is accumulating evidence to suggest that overexpression of efflux drug transporters at the blood-brain barrier, by reducing antiepileptic drug (AED) accumulation in the seizure foci, contributes to drug resistance in epilepsy. P-glycoprotein, encoded by the ABCB1 gene, is the most studied drug transporter. There are conflicting data as to whether the CC genotype of the ABCB1 3435C > T polymorphism is associated with drug resistance in Caucasian patients with epilepsy. We investigated this association in ethnic Chinese. ABCB1 3435C > T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls. Patients with drug-resistant epilepsy were more likely to have the TT genotype compared with those with drug-responsive epilepsy (16.7% vs 7.4%, odds ratio = 2.5, 95% confidence interval = 1.4-4.6, P = 0.0009). Our results contrast with those of studies of Caucasians, and highlight the complexity of the possible role of this polymorphism in AED response in different ethnic populations. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/143517
ISSN
2015 Impact Factor: 2.332
2015 SCImago Journal Rankings: 1.106
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwan, Pen_HK
dc.contributor.authorBaum, Len_HK
dc.contributor.authorWong, Ven_HK
dc.contributor.authorNg, PWen_HK
dc.contributor.authorLui, CHen_HK
dc.contributor.authorSin, NCen_HK
dc.contributor.authorHui, ACFen_HK
dc.contributor.authorYu, Een_HK
dc.contributor.authorWong, LKSen_HK
dc.date.accessioned2011-12-12T03:51:26Z-
dc.date.available2011-12-12T03:51:26Z-
dc.date.issued2007en_HK
dc.identifier.citationEpilepsy And Behavior, 2007, v. 11 n. 1, p. 112-117en_HK
dc.identifier.issn1525-5050en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143517-
dc.description.abstractThere is accumulating evidence to suggest that overexpression of efflux drug transporters at the blood-brain barrier, by reducing antiepileptic drug (AED) accumulation in the seizure foci, contributes to drug resistance in epilepsy. P-glycoprotein, encoded by the ABCB1 gene, is the most studied drug transporter. There are conflicting data as to whether the CC genotype of the ABCB1 3435C > T polymorphism is associated with drug resistance in Caucasian patients with epilepsy. We investigated this association in ethnic Chinese. ABCB1 3435C > T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls. Patients with drug-resistant epilepsy were more likely to have the TT genotype compared with those with drug-responsive epilepsy (16.7% vs 7.4%, odds ratio = 2.5, 95% confidence interval = 1.4-4.6, P = 0.0009). Our results contrast with those of studies of Caucasians, and highlight the complexity of the possible role of this polymorphism in AED response in different ethnic populations. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yebehen_HK
dc.relation.ispartofEpilepsy and Behavioren_HK
dc.subjectABCB1en_HK
dc.subjectAntiepileptic drugsen_HK
dc.subjectChineseen_HK
dc.subjectDrug resistanceen_HK
dc.subjectDrug transportersen_HK
dc.subjectEpilepsyen_HK
dc.subjectGenetic polymorphismsen_HK
dc.subjectMDR1en_HK
dc.subjectP-glycoproteinen_HK
dc.subjectPharmacogeneticsen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnticonvulsants/therapeutic useen_US
dc.subject.meshAsian Continental Ancestry Group/*geneticsen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshChinaen_US
dc.subject.meshDrug Resistance/*geneticsen_US
dc.subject.meshEpilepsy/drug therapy/ethnology/*geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshP-Glycoprotein/*geneticsen_US
dc.subject.meshPolymorphism, Single Nucleotide/*geneticsen_US
dc.titleAssociation between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.yebeh.2007.04.013en_HK
dc.identifier.pmid17521963-
dc.identifier.scopuseid_2-s2.0-34447619872en_HK
dc.identifier.hkuros132507-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447619872&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1en_HK
dc.identifier.spage112en_HK
dc.identifier.epage117en_HK
dc.identifier.isiWOS:000248680300018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwan, P=7004369601en_HK
dc.identifier.scopusauthoridBaum, L=7103310839en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK
dc.identifier.scopusauthoridNg, PW=7201376949en_HK
dc.identifier.scopusauthoridLui, CH=7006065991en_HK
dc.identifier.scopusauthoridSin, NC=6602256513en_HK
dc.identifier.scopusauthoridHui, ACF=7102453810en_HK
dc.identifier.scopusauthoridYu, E=9843775900en_HK
dc.identifier.scopusauthoridWong, LKS=8622252600en_HK
dc.identifier.citeulike5145192-

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