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Article: Ataxia telangiectasia in Chinese children. A clinical and electrophysiological study

TitleAtaxia telangiectasia in Chinese children. A clinical and electrophysiological study
Authors
Issue Date1987
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/clineuro
Citation
Clinical Neurology And Neurosurgery, 1987, v. 89 n. 3, p. 137-144 How to Cite?
AbstractThe clinical manifestations, immunological, chromosomal, and multimodal electrophysiological studies of five Chinese patients with ataxia telangiectasia are described. One died of hepatocellular carcinoma not associated with Hepatitis B-antigenaemia. Another died of respiratory failure. Two siblings are free of sinopulmonary infections although they are wheelchair bound. Computed tomography of the brain showed cerebellar atrophy in four cases. Nerve conduction studies showed evidence of axonal neuropathy in all cases with the earliest detection at six years. Electromyography showed mild denervation changes in two cases. Two patients had abnormal somatosensory evoked potentials and one had abnormal visual and brain stem auditory evoked potentials. The level of alpha foetal protein was elevated whereas the serum carcino-'mbryonic antigen was normal in all patients.
Persistent Identifierhttp://hdl.handle.net/10722/143505
ISSN
2015 Impact Factor: 1.198
2015 SCImago Journal Rankings: 0.555
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, Ven_HK
dc.contributor.authorYu, YLen_HK
dc.contributor.authorChanLui, WYen_HK
dc.date.accessioned2011-12-12T03:51:19Z-
dc.date.available2011-12-12T03:51:19Z-
dc.date.issued1987en_HK
dc.identifier.citationClinical Neurology And Neurosurgery, 1987, v. 89 n. 3, p. 137-144en_HK
dc.identifier.issn0303-8467en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143505-
dc.description.abstractThe clinical manifestations, immunological, chromosomal, and multimodal electrophysiological studies of five Chinese patients with ataxia telangiectasia are described. One died of hepatocellular carcinoma not associated with Hepatitis B-antigenaemia. Another died of respiratory failure. Two siblings are free of sinopulmonary infections although they are wheelchair bound. Computed tomography of the brain showed cerebellar atrophy in four cases. Nerve conduction studies showed evidence of axonal neuropathy in all cases with the earliest detection at six years. Electromyography showed mild denervation changes in two cases. Two patients had abnormal somatosensory evoked potentials and one had abnormal visual and brain stem auditory evoked potentials. The level of alpha foetal protein was elevated whereas the serum carcino-'mbryonic antigen was normal in all patients.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/clineuroen_HK
dc.relation.ispartofClinical Neurology and Neurosurgeryen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAtaxia Telangiectasia/*physiopathologyen_US
dc.subject.meshCerebellum/physiologyen_US
dc.subject.meshChilden_US
dc.subject.meshElectromyographyen_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshEvoked Potentialsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNeural Conductionen_US
dc.titleAtaxia telangiectasia in Chinese children. A clinical and electrophysiological studyen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid3665286-
dc.identifier.scopuseid_2-s2.0-0023269465en_HK
dc.identifier.volume89en_HK
dc.identifier.issue3en_HK
dc.identifier.spage137en_HK
dc.identifier.epage144en_HK
dc.identifier.isiWOS:A1987K375700002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK
dc.identifier.scopusauthoridYu, YL=8094845300en_HK
dc.identifier.scopusauthoridChanLui, WY=6507549100en_HK

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