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Article: Possible evidence for a variant of myasthenia gravis based on HLA and acetylcholine receptor antibody in Chinese patients

TitlePossible evidence for a variant of myasthenia gravis based on HLA and acetylcholine receptor antibody in Chinese patients
Authors
Issue Date1989
Citation
Quarterly Journal Of Medicine, 1989, v. 70 n. 263, p. 235-241 How to Cite?
AbstractA comprehensive study of 194 Chinese patients with myasthenia gravis in Hong Kong has shown distinct differences from the patterns of disease seen in Caucasians. Restricted ocular myasthenia is the predominant disease type in patients presenting in the first two decades of life and is associated with absence or low titres of acetylcholine receptor antibody. Predisposition to this type of disease is strongly associated with HLA-DRw9. Generalized myasthenia gravis occurs predominantly in patients presenting after the age of 20 years and is accompanied by high titres of acetylcholine receptor antibody but is less strongly associated with HLA-DRw9. It is suggested that myasthenia gravis occurring within the first two decades of life and characterized by affected ocular muscles and absence or low titre of acetylcholine receptor antibody is a genetically determined variant of the disease which occurs commonly in Orientals.
Persistent Identifierhttp://hdl.handle.net/10722/143503
ISSN
1998 Impact Factor: 2.244
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHawkins, BRen_HK
dc.contributor.authorYu, YLen_HK
dc.contributor.authorWong, Ven_HK
dc.contributor.authorWoo, Een_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorDawkins, RLen_HK
dc.date.accessioned2011-12-12T03:51:18Z-
dc.date.available2011-12-12T03:51:18Z-
dc.date.issued1989en_HK
dc.identifier.citationQuarterly Journal Of Medicine, 1989, v. 70 n. 263, p. 235-241en_HK
dc.identifier.issn0033-5622en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143503-
dc.description.abstractA comprehensive study of 194 Chinese patients with myasthenia gravis in Hong Kong has shown distinct differences from the patterns of disease seen in Caucasians. Restricted ocular myasthenia is the predominant disease type in patients presenting in the first two decades of life and is associated with absence or low titres of acetylcholine receptor antibody. Predisposition to this type of disease is strongly associated with HLA-DRw9. Generalized myasthenia gravis occurs predominantly in patients presenting after the age of 20 years and is accompanied by high titres of acetylcholine receptor antibody but is less strongly associated with HLA-DRw9. It is suggested that myasthenia gravis occurring within the first two decades of life and characterized by affected ocular muscles and absence or low titre of acetylcholine receptor antibody is a genetically determined variant of the disease which occurs commonly in Orientals.en_HK
dc.languageengen_US
dc.relation.ispartofQuarterly Journal of Medicineen_HK
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group/*geneticsen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Variation/geneticsen_US
dc.subject.meshHLA Antigens/geneticsen_US
dc.subject.meshHLA-DR Antigens/*geneticsen_US
dc.subject.meshHistocompatibility Testingen_US
dc.subject.meshHong Kong/epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMyasthenia Gravis/epidemiology/*geneticsen_US
dc.subject.meshReceptors, Cholinergic/*immunologyen_US
dc.titlePossible evidence for a variant of myasthenia gravis based on HLA and acetylcholine receptor antibody in Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, V:vcnwong@hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityWong, V=rp00334en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid2602536-
dc.identifier.scopuseid_2-s2.0-0024389480en_HK
dc.identifier.volume70en_HK
dc.identifier.issue263en_HK
dc.identifier.spage235en_HK
dc.identifier.epage241en_HK
dc.identifier.isiWOS:A1989U807200007-
dc.identifier.scopusauthoridHawkins, BR=35944486200en_HK
dc.identifier.scopusauthoridYu, YL=8094845300en_HK
dc.identifier.scopusauthoridWong, V=7202525632en_HK
dc.identifier.scopusauthoridWoo, E=7103371219en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridDawkins, RL=7101883836en_HK

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