Article: Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area

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TitleOccult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area
AuthorsHui, CK2
Sun, J1
Au, WY2
Lie, AKW2
Yueng, YH2
Zhang, HY2
Lee, NP2
Hou, JL1
Liang, R2
Lau, GKK2
KeywordsHematopoietic stem cell transplantation
Occult HBV
Prevalence of occult HBV
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
CitationJournal Of Hepatology, 2005, v. 42 n. 6, p. 813-819 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jhep.2005.01.018
AbstractBackground/Aims: The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors. Methods: We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive. Results: Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (P=0.45). Conclusions: The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
ISSN0168-8278
2011 Impact Factor: 9.264
2011 SCImago Journal Rankings: 0.765
DOIhttp://dx.doi.org/10.1016/j.jhep.2005.01.018
ISI Accession Number IDWOS:000229523400006
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHui, CK
dc.contributor.authorSun, J
dc.contributor.authorAu, WY
dc.contributor.authorLie, AKW
dc.contributor.authorYueng, YH
dc.contributor.authorZhang, HY
dc.contributor.authorLee, NP
dc.contributor.authorHou, JL
dc.contributor.authorLiang, R
dc.contributor.authorLau, GKK
dc.date.accessioned2011-12-02T05:19:24Z
dc.date.available2011-12-02T05:19:24Z
dc.date.issued2005
dc.description.abstractBackground/Aims: The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors. Methods: We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive. Results: Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (P=0.45). Conclusions: The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Hepatology, 2005, v. 42 n. 6, p. 813-819 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jhep.2005.01.018
dc.identifier.doihttp://dx.doi.org/10.1016/j.jhep.2005.01.018
dc.identifier.epage819
dc.identifier.hkuros98965
dc.identifier.isiWOS:000229523400006
dc.identifier.issn0168-8278
2011 Impact Factor: 9.264
2011 SCImago Journal Rankings: 0.765
dc.identifier.issue6
dc.identifier.pmid15885351
dc.identifier.scopuseid_2-s2.0-21044433150
dc.identifier.spage813
dc.identifier.urihttp://hdl.handle.net/10722/143474
dc.identifier.volume42
dc.languageeng
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
dc.publisher.placeNetherlands
dc.relation.ispartofJournal of Hepatology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshBlood Donors
dc.subject.meshCarrier State
dc.subject.meshDNA - Viral
dc.subject.meshEndemic Diseases
dc.subject.meshFemale
dc.subject.meshHematopoietic Stem Cell Transplantation
dc.subject.meshHepatitis B virus
dc.subject.meshHepatitis B - Chronic
dc.subject.meshHong Kong
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPredictive Value of Tests
dc.subject.meshPrevalence
dc.subject.meshRetrospective Studies
dc.subjectHematopoietic stem cell transplantation
dc.subjectOccult HBV
dc.subjectPrevalence of occult HBV
dc.titleOccult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area
dc.typeArticle
Author Affiliations
  1. Namfang Hospital
  2. The University of Hong Kong