File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area

TitleOccult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area
Authors
KeywordsHematopoietic stem cell transplantation
Occult HBV
Prevalence of occult HBV
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
Journal Of Hepatology, 2005, v. 42 n. 6, p. 813-819 How to Cite?
AbstractBackground/Aims: The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors. Methods: We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive. Results: Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (P=0.45). Conclusions: The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/143474
ISSN
2014 Impact Factor: 11.336
2014 SCImago Journal Rankings: 3.477
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, CKen_HK
dc.contributor.authorSun, Jen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorYueng, YHen_HK
dc.contributor.authorZhang, HYen_HK
dc.contributor.authorLee, NPen_HK
dc.contributor.authorHou, JLen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLau, GKKen_HK
dc.date.accessioned2011-12-02T05:19:24Z-
dc.date.available2011-12-02T05:19:24Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Hepatology, 2005, v. 42 n. 6, p. 813-819en_HK
dc.identifier.issn0168-8278en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143474-
dc.description.abstractBackground/Aims: The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors. Methods: We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive. Results: Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (P=0.45). Conclusions: The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhepen_HK
dc.relation.ispartofJournal of Hepatologyen_HK
dc.subjectHematopoietic stem cell transplantationen_HK
dc.subjectOccult HBVen_HK
dc.subjectPrevalence of occult HBVen_HK
dc.subject.meshAdulten_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshCarrier Stateen_US
dc.subject.meshDNA - Viralen_US
dc.subject.meshEndemic Diseasesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHematopoietic Stem Cell Transplantationen_US
dc.subject.meshHepatitis B virusen_US
dc.subject.meshHepatitis B - Chronicen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleOccult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic areaen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, NP: nikkilee@hku.hken_HK
dc.identifier.emailLiang, R: rliang@hku.hken_HK
dc.identifier.authorityLee, NP=rp00263en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jhep.2005.01.018en_HK
dc.identifier.pmid15885351en_HK
dc.identifier.scopuseid_2-s2.0-21044433150en_HK
dc.identifier.hkuros98965-
dc.identifier.hkuros111908-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21044433150&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue6en_HK
dc.identifier.spage813en_HK
dc.identifier.epage819en_HK
dc.identifier.isiWOS:000229523400006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHui, CK=35082057900en_HK
dc.identifier.scopusauthoridSun, J=7410369598en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridLie, AKW=7004510870en_HK
dc.identifier.scopusauthoridYueng, YH=8965962100en_HK
dc.identifier.scopusauthoridZhang, HY=8965962000en_HK
dc.identifier.scopusauthoridLee, NP=7402722690en_HK
dc.identifier.scopusauthoridHou, JL=14037396800en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats