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Article: Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area
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TitleOccult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area
 
AuthorsHui, CK2 2
Sun, J1
Au, WY2
Lie, AKW2
Yueng, YH2 2
Zhang, HY2 2
Lee, NP2
Hou, JL1
Liang, R2
Lau, GKK2 2
 
KeywordsHematopoietic stem cell transplantation
Occult HBV
Prevalence of occult HBV
 
Issue Date2005
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
 
CitationJournal Of Hepatology, 2005, v. 42 n. 6, p. 813-819 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jhep.2005.01.018
 
AbstractBackground/Aims: The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors. Methods: We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive. Results: Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (P=0.45). Conclusions: The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
 
ISSN0168-8278
2012 Impact Factor: 9.858
2012 SCImago Journal Rankings: 2.797
 
DOIhttp://dx.doi.org/10.1016/j.jhep.2005.01.018
 
ISI Accession Number IDWOS:000229523400006
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHui, CK
 
dc.contributor.authorSun, J
 
dc.contributor.authorAu, WY
 
dc.contributor.authorLie, AKW
 
dc.contributor.authorYueng, YH
 
dc.contributor.authorZhang, HY
 
dc.contributor.authorLee, NP
 
dc.contributor.authorHou, JL
 
dc.contributor.authorLiang, R
 
dc.contributor.authorLau, GKK
 
dc.date.accessioned2011-12-02T05:19:24Z
 
dc.date.available2011-12-02T05:19:24Z
 
dc.date.issued2005
 
dc.description.abstractBackground/Aims: The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors. Methods: We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive. Results: Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (P=0.45). Conclusions: The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Hepatology, 2005, v. 42 n. 6, p. 813-819 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jhep.2005.01.018
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jhep.2005.01.018
 
dc.identifier.epage819
 
dc.identifier.hkuros98965
 
dc.identifier.hkuros111908
 
dc.identifier.isiWOS:000229523400006
 
dc.identifier.issn0168-8278
2012 Impact Factor: 9.858
2012 SCImago Journal Rankings: 2.797
 
dc.identifier.issue6
 
dc.identifier.pmid15885351
 
dc.identifier.scopuseid_2-s2.0-21044433150
 
dc.identifier.spage813
 
dc.identifier.urihttp://hdl.handle.net/10722/143474
 
dc.identifier.volume42
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofJournal of Hepatology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshBlood Donors
 
dc.subject.meshCarrier State
 
dc.subject.meshDNA - Viral
 
dc.subject.meshEndemic Diseases
 
dc.subject.meshFemale
 
dc.subject.meshHematopoietic Stem Cell Transplantation
 
dc.subject.meshHepatitis B virus
 
dc.subject.meshHepatitis B - Chronic
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPredictive Value of Tests
 
dc.subject.meshPrevalence
 
dc.subject.meshRetrospective Studies
 
dc.subjectHematopoietic stem cell transplantation
 
dc.subjectOccult HBV
 
dc.subjectPrevalence of occult HBV
 
dc.titleOccult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area
 
dc.typeArticle
 
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<contributor.author>Sun, J</contributor.author>
<contributor.author>Au, WY</contributor.author>
<contributor.author>Lie, AKW</contributor.author>
<contributor.author>Yueng, YH</contributor.author>
<contributor.author>Zhang, HY</contributor.author>
<contributor.author>Lee, NP</contributor.author>
<contributor.author>Hou, JL</contributor.author>
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<description.abstract>Background/Aims: The acquisition of hepatitis B virus (HBV) infection following organ transplantation from donors with occult HBV infection is an important cause of morbidity and mortality. The aim of this study is to determine the prevalence of occult HBV in allogeneic hematopoietic stem cell (HSC) transplantation donors. Methods: We performed a retrospective study on 124 consecutive hepatitis B surface antigen negative HSC donors. Their serum samples were analyzed by PCR for the pre-S/S, pre-core/core and X regions of the virus. Samples reactive by at least two PCR assays were considered HBV-DNA positive. Results: Nineteen of the 124 HSC donors (15.3%) had occult HBV infection. Sixteen of these 19 donors with occult HBV infection (84.2%) tested positive for hepatitis B core antibody while 78 of 105 subjects (74.3%) without occult HBV infection were also positive (P=0.56). Fourteen of the 19 donors (73.7%) with occult HBV infection tested positive for hepatitis B surface antibody while 67 of the 105 subjects without occult HBV infection were also positive (P=0.45). Conclusions: The prevalence of occult HBV infection among HSC donors in Hong Kong is high. Anti-HBc and anti-HBs status had no significant correlation with the presence of occult HBV infection. &#169; 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</description.abstract>
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Author Affiliations
  1. Namfang Hospital
  2. The University of Hong Kong