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Article: Cochrane reviews on the benefits/risks of fluoride toothpastes

TitleCochrane reviews on the benefits/risks of fluoride toothpastes
Authors
Keywordscaries
evidence-based medicine
fluoride
systematic review
Issue Date2011
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2011, v. 90 n. 5, p. 573-579 How to Cite?
AbstractThis concise review presents two Cochrane Reviews undertaken to determine: (1) the relative effectiveness of fluoride toothpastes of different concentrations in preventing dental caries in children and adolescents; and (2) the relationship between the use of topical fluorides in young children and their risk of developing dental fluorosis. To determine the relative effectiveness of fluoride toothpastes of different concentrations, we undertook a network meta-analysis utilizing both direct and indirect comparisons from randomized controlled trials (RCTs). The review examining fluorosis included evidence from experimental and observational studies. The findings of the reviews confirm the benefits of using fluoride toothpaste, when compared with placebo, in preventing caries in children and adolescents, but only significantly for fluoride concentrations of 1000 ppm and above. The relative caries-preventive effects of fluoride toothpastes of different concentrations increase with higher fluoride concentration. However, there is weak, unreliable evidence that starting the use of fluoride toothpaste in children under 12 months of age may be associated with an increased risk of fluorosis. The decision of what fluoride levels to use for children under 6 years should be balanced between the risk of developing dental caries and that of mild fluorosis. © 2011 International & American Associations for Dental Research.
Persistent Identifierhttp://hdl.handle.net/10722/143463
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
Funding AgencyGrant Number
Cochrane Oral Health Group
Manchester Biomedical Research Centre
Department of Health, UK
National Institute for Health Research (NIHR), UK
The University of Hong Kong, HK200807176031
Funding Information:

The review authors acknowledge the support of the Cochrane Oral Health Group, the peer reviewers for their extensive and helpful comments on earlier drafts of this review, and the Manchester Biomedical Research Centre. This work was supported by: the Department of Health Cochrane Review Incentive Scheme 2008, UK; the National Institute for Health Research (NIHR), UK; and The University of Hong Kong (CRCG grant project no. 200807176031), HK.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, MCMen_HK
dc.contributor.authorClarkson, Jen_HK
dc.contributor.authorGlenny, AMen_HK
dc.contributor.authorLo, ECMen_HK
dc.contributor.authorMarinho, VCCen_HK
dc.contributor.authorTsang, BWKen_HK
dc.contributor.authorWalsh, Ten_HK
dc.contributor.authorWorthington, HVen_HK
dc.date.accessioned2011-12-01T03:45:13Z-
dc.date.available2011-12-01T03:45:13Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Dental Research, 2011, v. 90 n. 5, p. 573-579en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143463-
dc.description.abstractThis concise review presents two Cochrane Reviews undertaken to determine: (1) the relative effectiveness of fluoride toothpastes of different concentrations in preventing dental caries in children and adolescents; and (2) the relationship between the use of topical fluorides in young children and their risk of developing dental fluorosis. To determine the relative effectiveness of fluoride toothpastes of different concentrations, we undertook a network meta-analysis utilizing both direct and indirect comparisons from randomized controlled trials (RCTs). The review examining fluorosis included evidence from experimental and observational studies. The findings of the reviews confirm the benefits of using fluoride toothpaste, when compared with placebo, in preventing caries in children and adolescents, but only significantly for fluoride concentrations of 1000 ppm and above. The relative caries-preventive effects of fluoride toothpastes of different concentrations increase with higher fluoride concentration. However, there is weak, unreliable evidence that starting the use of fluoride toothpaste in children under 12 months of age may be associated with an increased risk of fluorosis. The decision of what fluoride levels to use for children under 6 years should be balanced between the risk of developing dental caries and that of mild fluorosis. © 2011 International & American Associations for Dental Research.en_HK
dc.languageeng-
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc..-
dc.subjectcariesen_HK
dc.subjectevidence-based medicineen_HK
dc.subjectfluorideen_HK
dc.subjectsystematic reviewen_HK
dc.subject.meshCariostatic Agents - administration and dosage - adverse effects - therapeutic use-
dc.subject.meshDental Caries - prevention and control-
dc.subject.meshFluorides - administration and dosage - adverse effects - therapeutic use-
dc.subject.meshFluorosis, Dental - etiology-
dc.subject.meshToothpastes - adverse effects - chemistry - therapeutic use-
dc.titleCochrane reviews on the benefits/risks of fluoride toothpastesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=90&issue=5&spage=573&epage=579&date=2011&atitle=Cochrane+reviews+on+the+benefits/risks+of+fluoride+toothpastes-
dc.identifier.emailWong, MCM:mcmwong@hkucc.hku.hken_HK
dc.identifier.emailLo, ECM:hrdplcm@hkucc.hku.hken_HK
dc.identifier.authorityWong, MCM=rp00024en_HK
dc.identifier.authorityLo, ECM=rp00015en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0022034510393346en_HK
dc.identifier.pmid21248357-
dc.identifier.scopuseid_2-s2.0-79955854105en_HK
dc.identifier.hkuros185545-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955854105&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume90en_HK
dc.identifier.issue5en_HK
dc.identifier.spage573en_HK
dc.identifier.epage579en_HK
dc.identifier.eissn1544-0591-
dc.identifier.isiWOS:000289490000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, MCM=26029250900en_HK
dc.identifier.scopusauthoridClarkson, J=7102852990en_HK
dc.identifier.scopusauthoridGlenny, AM=7004684536en_HK
dc.identifier.scopusauthoridLo, ECM=7101705982en_HK
dc.identifier.scopusauthoridMarinho, VCC=7004346070en_HK
dc.identifier.scopusauthoridTsang, BWK=35114041400en_HK
dc.identifier.scopusauthoridWalsh, T=25630088500en_HK
dc.identifier.scopusauthoridWorthington, HV=7102322448en_HK

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