Article: Prevention of nosocomial transmission of norovirus by strategic infection control measures
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- Publisher Website: 10.1086/658330
- Scopus: eid_2-s2.0-79952394548
- PMID: 21460507
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| Title | Prevention of nosocomial transmission of norovirus by strategic infection control measures |
|---|---|
| Authors | Cheng, VCC Wong, LMW Tai, JWM Chan, JFW To, KKW Li, IWS Hung, IFN Chan, KH Ho, PL Yuen, KY |
| Issue Date | 2011 |
| Publisher | University of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.html |
| Citation | Infection Control And Hospital Epidemiology, 2011, v. 32 n. 3, p. 229-237 [How to Cite?] DOI: http://dx.doi.org/10.1086/658330 |
| Abstract | BACKGROUND. Nosocomial outbreaks of norovirus infection pose a great challenge to the infection control team. METHODS. Between November 1, 2009, and February 28, 2010, strategic infection control measures were implemented in a hospital network. In addition to timely staff education and promotion of directly observed hand hygiene, reverse-transcription polymerase chain reaction for norovirus was performed as an added test by the microbiology laboratory for all fecal specimens irrespective of the request for testing. Laboratory-confirmed cases were followed up by the infection control team for timely intervention. The incidence of hospitalacquired norovirus infection per 1,000 potentially infectious patient-days was compared with the corresponding period in the preceding 12 months, and the incidence in the other 6 hospital networks in Hong Kong was chosen as the concurrent control. Phylogenetic analysis of norovirus isolates was performed. RESULTS. Of the 988 patients who were tested, 242 (25%) were positive for norovirus; 114 (47%) of those 242 patients had norovirus detected by our added test. Compared with the corresponding period in the preceding 12 months, the incidence of hospital-acquired norovirus infection decreased from 131 to 16 cases per 1,000 potentially infectious patient-days (P< .001), although the number of hospitalacquired infections was low in both the study period (n=8) and the historical control periods (n=11). The incidence of hospital-acquired norovirus infection in our hospital network (0.03 cases per 1,000 patient-days) was significantly lower than that of the concurrent control (0.06 cases per 1,000 patient-days) (P=.015). Forty-three (93%) of 46 norovirus isolates sequenced belonged to the genogroup II.4 variant. CONCLUSIONS. Strategic infection control measures with an added test may be useful in controlling nosocomial transmission of norovirus. © 2011 by The Society for Healthcare Epidemiology of America. All rights reserved. |
| ISSN | 0899-823X 2011 Impact Factor: 3.669 2011 SCImago Journal Rankings: 0.448 |
| DOI | http://dx.doi.org/10.1086/658330 |
| References | References in Scopus |
| dc.contributor.author | Cheng, VCC | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Wong, LMW | ||||||
| dc.contributor.author | Tai, JWM | ||||||
| dc.contributor.author | Chan, JFW | ||||||
| dc.contributor.author | To, KKW | ||||||
| dc.contributor.author | Li, IWS | ||||||
| dc.contributor.author | Hung, IFN | ||||||
| dc.contributor.author | Chan, KH | ||||||
| dc.contributor.author | Ho, PL | ||||||
| dc.contributor.author | Yuen, KY | ||||||
| dc.date.accessioned | 2011-11-24T10:04:08Z | ||||||
| dc.date.available | 2011-11-24T10:04:08Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | BACKGROUND. Nosocomial outbreaks of norovirus infection pose a great challenge to the infection control team. METHODS. Between November 1, 2009, and February 28, 2010, strategic infection control measures were implemented in a hospital network. In addition to timely staff education and promotion of directly observed hand hygiene, reverse-transcription polymerase chain reaction for norovirus was performed as an added test by the microbiology laboratory for all fecal specimens irrespective of the request for testing. Laboratory-confirmed cases were followed up by the infection control team for timely intervention. The incidence of hospitalacquired norovirus infection per 1,000 potentially infectious patient-days was compared with the corresponding period in the preceding 12 months, and the incidence in the other 6 hospital networks in Hong Kong was chosen as the concurrent control. Phylogenetic analysis of norovirus isolates was performed. RESULTS. Of the 988 patients who were tested, 242 (25%) were positive for norovirus; 114 (47%) of those 242 patients had norovirus detected by our added test. Compared with the corresponding period in the preceding 12 months, the incidence of hospital-acquired norovirus infection decreased from 131 to 16 cases per 1,000 potentially infectious patient-days (P< .001), although the number of hospitalacquired infections was low in both the study period (n=8) and the historical control periods (n=11). The incidence of hospital-acquired norovirus infection in our hospital network (0.03 cases per 1,000 patient-days) was significantly lower than that of the concurrent control (0.06 cases per 1,000 patient-days) (P=.015). Forty-three (93%) of 46 norovirus isolates sequenced belonged to the genogroup II.4 variant. CONCLUSIONS. Strategic infection control measures with an added test may be useful in controlling nosocomial transmission of norovirus. © 2011 by The Society for Healthcare Epidemiology of America. All rights reserved. | ||||||
| dc.description.nature | published_or_final_version | ||||||
| dc.identifier.citation | Infection Control And Hospital Epidemiology, 2011, v. 32 n. 3, p. 229-237 [How to Cite?] DOI: http://dx.doi.org/10.1086/658330 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1086/658330 | ||||||
| dc.identifier.epage | 237 | ||||||
| dc.identifier.hkuros | 197695 | ||||||
| dc.identifier.hkuros | 190823 | ||||||
| dc.identifier.isi | WOS:000292614200005
Funding Information: We thank Dr P. Y. Leung of the Hospital Authority for facilitating this study. This work was partly funded by Suen Chi Sun Charitable Foundation and Research Fund for the Control of Infectious Diseases (RFCID). | ||||||
| dc.identifier.issn | 0899-823X 2011 Impact Factor: 3.669 2011 SCImago Journal Rankings: 0.448 | ||||||
| dc.identifier.issue | 3 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 21460507 | ||||||
| dc.identifier.scopus | eid_2-s2.0-79952394548 | ||||||
| dc.identifier.spage | 229 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/143370 | ||||||
| dc.identifier.volume | 32 | ||||||
| dc.language | eng | ||||||
| dc.publisher | University of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.html | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Infection Control and Hospital Epidemiology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License | ||||||
| dc.subject.mesh | Caliciviridae Infections - epidemiology - prevention and control - transmission | ||||||
| dc.subject.mesh | Cross Infection - epidemiology - prevention and control - transmission | ||||||
| dc.subject.mesh | Disease Outbreaks - prevention and control - statistics and numerical data | ||||||
| dc.subject.mesh | Infection Control - methods | ||||||
| dc.subject.mesh | Norovirus - genetics - isolation and purification | ||||||
| dc.title | Prevention of nosocomial transmission of norovirus by strategic infection control measures | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Queen Mary Hospital Hong Kong