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Article: Prevention of nosocomial transmission of norovirus by strategic infection control measures
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TitlePrevention of nosocomial transmission of norovirus by strategic infection control measures
 
AuthorsCheng, VCC1 2
Wong, LMW2
Tai, JWM2
Chan, JFW1
To, KKW1
Li, IWS1
Hung, IFN2
Chan, KH1
Ho, PL1
Yuen, KY1
 
Issue Date2011
 
PublisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.html
 
CitationInfection Control And Hospital Epidemiology, 2011, v. 32 n. 3, p. 229-237 [How to Cite?]
DOI: http://dx.doi.org/10.1086/658330
 
AbstractBACKGROUND. Nosocomial outbreaks of norovirus infection pose a great challenge to the infection control team. METHODS. Between November 1, 2009, and February 28, 2010, strategic infection control measures were implemented in a hospital network. In addition to timely staff education and promotion of directly observed hand hygiene, reverse-transcription polymerase chain reaction for norovirus was performed as an added test by the microbiology laboratory for all fecal specimens irrespective of the request for testing. Laboratory-confirmed cases were followed up by the infection control team for timely intervention. The incidence of hospitalacquired norovirus infection per 1,000 potentially infectious patient-days was compared with the corresponding period in the preceding 12 months, and the incidence in the other 6 hospital networks in Hong Kong was chosen as the concurrent control. Phylogenetic analysis of norovirus isolates was performed. RESULTS. Of the 988 patients who were tested, 242 (25%) were positive for norovirus; 114 (47%) of those 242 patients had norovirus detected by our added test. Compared with the corresponding period in the preceding 12 months, the incidence of hospital-acquired norovirus infection decreased from 131 to 16 cases per 1,000 potentially infectious patient-days (P< .001), although the number of hospitalacquired infections was low in both the study period (n=8) and the historical control periods (n=11). The incidence of hospital-acquired norovirus infection in our hospital network (0.03 cases per 1,000 patient-days) was significantly lower than that of the concurrent control (0.06 cases per 1,000 patient-days) (P=.015). Forty-three (93%) of 46 norovirus isolates sequenced belonged to the genogroup II.4 variant. CONCLUSIONS. Strategic infection control measures with an added test may be useful in controlling nosocomial transmission of norovirus. © 2011 by The Society for Healthcare Epidemiology of America. All rights reserved.
 
ISSN0899-823X
2012 Impact Factor: 4.02
2012 SCImago Journal Rankings: 2.082
 
DOIhttp://dx.doi.org/10.1086/658330
 
ISI Accession Number IDWOS:000292614200005
Funding AgencyGrant Number
Suen Chi Sun Charitable Foundation
Research Fund for the Control of Infectious Diseases (RFCID)
Funding Information:

We thank Dr P. Y. Leung of the Hospital Authority for facilitating this study. This work was partly funded by Suen Chi Sun Charitable Foundation and Research Fund for the Control of Infectious Diseases (RFCID).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheng, VCC
 
dc.contributor.authorWong, LMW
 
dc.contributor.authorTai, JWM
 
dc.contributor.authorChan, JFW
 
dc.contributor.authorTo, KKW
 
dc.contributor.authorLi, IWS
 
dc.contributor.authorHung, IFN
 
dc.contributor.authorChan, KH
 
dc.contributor.authorHo, PL
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2011-11-24T10:04:08Z
 
dc.date.available2011-11-24T10:04:08Z
 
dc.date.issued2011
 
dc.description.abstractBACKGROUND. Nosocomial outbreaks of norovirus infection pose a great challenge to the infection control team. METHODS. Between November 1, 2009, and February 28, 2010, strategic infection control measures were implemented in a hospital network. In addition to timely staff education and promotion of directly observed hand hygiene, reverse-transcription polymerase chain reaction for norovirus was performed as an added test by the microbiology laboratory for all fecal specimens irrespective of the request for testing. Laboratory-confirmed cases were followed up by the infection control team for timely intervention. The incidence of hospitalacquired norovirus infection per 1,000 potentially infectious patient-days was compared with the corresponding period in the preceding 12 months, and the incidence in the other 6 hospital networks in Hong Kong was chosen as the concurrent control. Phylogenetic analysis of norovirus isolates was performed. RESULTS. Of the 988 patients who were tested, 242 (25%) were positive for norovirus; 114 (47%) of those 242 patients had norovirus detected by our added test. Compared with the corresponding period in the preceding 12 months, the incidence of hospital-acquired norovirus infection decreased from 131 to 16 cases per 1,000 potentially infectious patient-days (P< .001), although the number of hospitalacquired infections was low in both the study period (n=8) and the historical control periods (n=11). The incidence of hospital-acquired norovirus infection in our hospital network (0.03 cases per 1,000 patient-days) was significantly lower than that of the concurrent control (0.06 cases per 1,000 patient-days) (P=.015). Forty-three (93%) of 46 norovirus isolates sequenced belonged to the genogroup II.4 variant. CONCLUSIONS. Strategic infection control measures with an added test may be useful in controlling nosocomial transmission of norovirus. © 2011 by The Society for Healthcare Epidemiology of America. All rights reserved.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationInfection Control And Hospital Epidemiology, 2011, v. 32 n. 3, p. 229-237 [How to Cite?]
DOI: http://dx.doi.org/10.1086/658330
 
dc.identifier.doihttp://dx.doi.org/10.1086/658330
 
dc.identifier.epage237
 
dc.identifier.hkuros197695
 
dc.identifier.hkuros190823
 
dc.identifier.isiWOS:000292614200005
Funding AgencyGrant Number
Suen Chi Sun Charitable Foundation
Research Fund for the Control of Infectious Diseases (RFCID)
Funding Information:

We thank Dr P. Y. Leung of the Hospital Authority for facilitating this study. This work was partly funded by Suen Chi Sun Charitable Foundation and Research Fund for the Control of Infectious Diseases (RFCID).

 
dc.identifier.issn0899-823X
2012 Impact Factor: 4.02
2012 SCImago Journal Rankings: 2.082
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid21460507
 
dc.identifier.scopuseid_2-s2.0-79952394548
 
dc.identifier.spage229
 
dc.identifier.urihttp://hdl.handle.net/10722/143370
 
dc.identifier.volume32
 
dc.languageeng
 
dc.publisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.html
 
dc.publisher.placeUnited States
 
dc.relation.ispartofInfection Control and Hospital Epidemiology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshCaliciviridae Infections - epidemiology - prevention and control - transmission
 
dc.subject.meshCross Infection - epidemiology - prevention and control - transmission
 
dc.subject.meshDisease Outbreaks - prevention and control - statistics and numerical data
 
dc.subject.meshInfection Control - methods
 
dc.subject.meshNorovirus - genetics - isolation and purification
 
dc.titlePrevention of nosocomial transmission of norovirus by strategic infection control measures
 
dc.typeArticle
 
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<contributor.author>Chan, JFW</contributor.author>
<contributor.author>To, KKW</contributor.author>
<contributor.author>Li, IWS</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong