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Article: Prevention of nosocomial transmission of norovirus by strategic infection control measures

TitlePrevention of nosocomial transmission of norovirus by strategic infection control measures
Authors
Issue Date2011
PublisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.html
Citation
Infection Control And Hospital Epidemiology, 2011, v. 32 n. 3, p. 229-237 How to Cite?
Abstract
BACKGROUND. Nosocomial outbreaks of norovirus infection pose a great challenge to the infection control team. METHODS. Between November 1, 2009, and February 28, 2010, strategic infection control measures were implemented in a hospital network. In addition to timely staff education and promotion of directly observed hand hygiene, reverse-transcription polymerase chain reaction for norovirus was performed as an added test by the microbiology laboratory for all fecal specimens irrespective of the request for testing. Laboratory-confirmed cases were followed up by the infection control team for timely intervention. The incidence of hospitalacquired norovirus infection per 1,000 potentially infectious patient-days was compared with the corresponding period in the preceding 12 months, and the incidence in the other 6 hospital networks in Hong Kong was chosen as the concurrent control. Phylogenetic analysis of norovirus isolates was performed. RESULTS. Of the 988 patients who were tested, 242 (25%) were positive for norovirus; 114 (47%) of those 242 patients had norovirus detected by our added test. Compared with the corresponding period in the preceding 12 months, the incidence of hospital-acquired norovirus infection decreased from 131 to 16 cases per 1,000 potentially infectious patient-days (P< .001), although the number of hospitalacquired infections was low in both the study period (n=8) and the historical control periods (n=11). The incidence of hospital-acquired norovirus infection in our hospital network (0.03 cases per 1,000 patient-days) was significantly lower than that of the concurrent control (0.06 cases per 1,000 patient-days) (P=.015). Forty-three (93%) of 46 norovirus isolates sequenced belonged to the genogroup II.4 variant. CONCLUSIONS. Strategic infection control measures with an added test may be useful in controlling nosocomial transmission of norovirus. © 2011 by The Society for Healthcare Epidemiology of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/143370
ISSN
2013 Impact Factor: 3.938
2013 SCImago Journal Rankings: 2.413
ISI Accession Number ID
Funding AgencyGrant Number
Suen Chi Sun Charitable Foundation
Research Fund for the Control of Infectious Diseases (RFCID)
Funding Information:

We thank Dr P. Y. Leung of the Hospital Authority for facilitating this study. This work was partly funded by Suen Chi Sun Charitable Foundation and Research Fund for the Control of Infectious Diseases (RFCID).

References

 

Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorWong, LMWen_HK
dc.contributor.authorTai, JWMen_HK
dc.contributor.authorChan, JFWen_HK
dc.contributor.authorTo, KKWen_HK
dc.contributor.authorLi, IWSen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2011-11-24T10:04:08Z-
dc.date.available2011-11-24T10:04:08Z-
dc.date.issued2011en_HK
dc.identifier.citationInfection Control And Hospital Epidemiology, 2011, v. 32 n. 3, p. 229-237en_HK
dc.identifier.issn0899-823Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/143370-
dc.description.abstractBACKGROUND. Nosocomial outbreaks of norovirus infection pose a great challenge to the infection control team. METHODS. Between November 1, 2009, and February 28, 2010, strategic infection control measures were implemented in a hospital network. In addition to timely staff education and promotion of directly observed hand hygiene, reverse-transcription polymerase chain reaction for norovirus was performed as an added test by the microbiology laboratory for all fecal specimens irrespective of the request for testing. Laboratory-confirmed cases were followed up by the infection control team for timely intervention. The incidence of hospitalacquired norovirus infection per 1,000 potentially infectious patient-days was compared with the corresponding period in the preceding 12 months, and the incidence in the other 6 hospital networks in Hong Kong was chosen as the concurrent control. Phylogenetic analysis of norovirus isolates was performed. RESULTS. Of the 988 patients who were tested, 242 (25%) were positive for norovirus; 114 (47%) of those 242 patients had norovirus detected by our added test. Compared with the corresponding period in the preceding 12 months, the incidence of hospital-acquired norovirus infection decreased from 131 to 16 cases per 1,000 potentially infectious patient-days (P< .001), although the number of hospitalacquired infections was low in both the study period (n=8) and the historical control periods (n=11). The incidence of hospital-acquired norovirus infection in our hospital network (0.03 cases per 1,000 patient-days) was significantly lower than that of the concurrent control (0.06 cases per 1,000 patient-days) (P=.015). Forty-three (93%) of 46 norovirus isolates sequenced belonged to the genogroup II.4 variant. CONCLUSIONS. Strategic infection control measures with an added test may be useful in controlling nosocomial transmission of norovirus. © 2011 by The Society for Healthcare Epidemiology of America. All rights reserved.en_HK
dc.languageengen_US
dc.publisherUniversity of Chicago Press. The Journal's web site is located at http://www.journals.uchicago.edu/ICHE/home.htmlen_HK
dc.relation.ispartofInfection Control and Hospital Epidemiologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCaliciviridae Infections - epidemiology - prevention and control - transmission-
dc.subject.meshCross Infection - epidemiology - prevention and control - transmission-
dc.subject.meshDisease Outbreaks - prevention and control - statistics and numerical data-
dc.subject.meshInfection Control - methods-
dc.subject.meshNorovirus - genetics - isolation and purification-
dc.titlePrevention of nosocomial transmission of norovirus by strategic infection control measuresen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0899-823X&volume=32&issue=3&spage=229&epage=237&date=2011&atitle=Prevention+of+nosocomial+transmission+of+norovirus+by+strategic+infection+control+measuresen_US
dc.identifier.emailChan, JFW: jfwchan@hku.hken_HK
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hken_HK
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hken_HK
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityChan, JFW=rp01736en_HK
dc.identifier.authorityTo, KKW=rp01384en_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1086/658330en_HK
dc.identifier.pmid21460507en_HK
dc.identifier.scopuseid_2-s2.0-79952394548en_HK
dc.identifier.hkuros197695en_US
dc.identifier.hkuros190823-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952394548&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue3en_HK
dc.identifier.spage229en_HK
dc.identifier.epage237en_HK
dc.identifier.isiWOS:000292614200005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheng, VCC=38662328400en_HK
dc.identifier.scopusauthoridWong, LMW=26022708100en_HK
dc.identifier.scopusauthoridTai, JWM=7101993154en_HK
dc.identifier.scopusauthoridChan, JFW=24278817900en_HK
dc.identifier.scopusauthoridTo, KKW=14323807300en_HK
dc.identifier.scopusauthoridLi, IWS=24464179500en_HK
dc.identifier.scopusauthoridHung, IFN=7006103457en_HK
dc.identifier.scopusauthoridChan, KH=35338760600en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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