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Article: Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1

TitleIdentification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1
Authors
KeywordsFluorescence in situ hybridization
Hematological malignancies
hLH-2
Philadelphia chromosome
Reverse transcription-polymerase chain reaction
Issue Date1996
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1996, v. 12 n. 6, p. 1205-1212 How to Cite?
AbstractWe describe the isolation of human LH-2, a putative transcription factor containing two cysteine-rich regions (LIM domains) and a homeobox (Hox) DNA-binding domain. High levels of hLH-2 expression were observed in all cases of chronic myelogenous leukaemia (CML) tested, regardless of disease status. hLH-2 was mapped to chromosome 9q33-34.1, in the same region as the reciprocal translocation that creates the BCR-ABL chimera of the Philadelphia chromosome (Ph'), the hallmark of CML; hLH-2 was retained on the derivative 9 chromosome and is therefore centromeric of c-ABL. The proximity of hLH-2 to the breakpoint on chromosome 9 raises the possibility of cis-activation by the t(9;22)(q34;q11) translocation. In addition to finding hLH-2 expression in all cases of CML, expression was observed in lymphoid malignancies and myeloid cell lines, but not in primary cases of acute myelogenous leukaemia. The role of hLH-2 in the development or progression of leukaemia is not known. However, hLH-2 may prove useful as a marker of CML for residual disease.
Persistent Identifierhttp://hdl.handle.net/10722/143352
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, HKen_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorSiderovski, DPen_HK
dc.contributor.authorDong, WFen_HK
dc.contributor.authorOkuno, Yen_HK
dc.contributor.authorShi, XMen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorMinden, MDen_HK
dc.date.accessioned2011-11-24T04:42:25Z-
dc.date.available2011-11-24T04:42:25Z-
dc.date.issued1996en_HK
dc.identifier.citationOncogene, 1996, v. 12 n. 6, p. 1205-1212en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143352-
dc.description.abstractWe describe the isolation of human LH-2, a putative transcription factor containing two cysteine-rich regions (LIM domains) and a homeobox (Hox) DNA-binding domain. High levels of hLH-2 expression were observed in all cases of chronic myelogenous leukaemia (CML) tested, regardless of disease status. hLH-2 was mapped to chromosome 9q33-34.1, in the same region as the reciprocal translocation that creates the BCR-ABL chimera of the Philadelphia chromosome (Ph'), the hallmark of CML; hLH-2 was retained on the derivative 9 chromosome and is therefore centromeric of c-ABL. The proximity of hLH-2 to the breakpoint on chromosome 9 raises the possibility of cis-activation by the t(9;22)(q34;q11) translocation. In addition to finding hLH-2 expression in all cases of CML, expression was observed in lymphoid malignancies and myeloid cell lines, but not in primary cases of acute myelogenous leukaemia. The role of hLH-2 in the development or progression of leukaemia is not known. However, hLH-2 may prove useful as a marker of CML for residual disease.en_HK
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subjectFluorescence in situ hybridizationen_HK
dc.subjectHematological malignanciesen_HK
dc.subjecthLH-2en_HK
dc.subjectPhiladelphia chromosomeen_HK
dc.subjectReverse transcription-polymerase chain reactionen_HK
dc.subject.meshChromosomes, Human, Pair 9-
dc.subject.meshGenes, Homeobox-
dc.subject.meshHomeodomain Proteins - biosynthesis - genetics-
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics - metabolism-
dc.subject.meshTranscription Factors - biosynthesis - genetics-
dc.titleIdentification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9232&volume=12&issue=6&spage=1205&epage=1212&date=1996&atitle=Identification+of+a+human+LIM-Hox+gene,+hLH-2,+aberrantly+expressed+in+chronic+myelogenous+leukaemia+and+located+on+9q33-34.1-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8649822-
dc.identifier.scopuseid_2-s2.0-0029932297en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029932297&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1205en_HK
dc.identifier.epage1212en_HK
dc.identifier.isiWOS:A1996UC06700005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWu, HK=7405580986en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridSiderovski, DP=7004949965en_HK
dc.identifier.scopusauthoridDong, WF=7202224322en_HK
dc.identifier.scopusauthoridOkuno, Y=7202192899en_HK
dc.identifier.scopusauthoridShi, XM=7402953863en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridMinden, MD=7006060361en_HK

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