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Article: Preparation of porous scaffolds of borosilicate bioglass

TitlePreparation of porous scaffolds of borosilicate bioglass
硼硅酸鹽生物活性玻璃多孔支架的制備
Authors
KeywordsBorosilicate bioglass (硼硅酸鹽生物活性玻璃)
Replication technique (有機泡沫浸漬法)
Scaffolds (多孔支架)
Slurry (漿料)
Issue Date2008
PublisherScience Press (科學出版社)
Citation
Journal Of Inorganic Materials, 2008, v. 23 n. 2, p. 322-326 How to Cite?
無機材料學報, 2008, v. 23 n. 2, p. 322-326 How to Cite?
AbstractA borosilicate bioglass in Na 2O-CaO-SiO 2-P 2O 5- B 2O 3 system is a bioactive and biodegradable material for tissue engineering. In this study, the bioactive porous scaffolds with three-dimensional interconnection were fabricated by replication technique, using borosilicate bioglass powder to form slurry with ethanol as solvent and ethyl-cellulose as additive. The compressive strength of scaffolds increases from 0.03MPa to 0.36MPa by adjusting the slurry load, the solid concentration and the ethyl-cellulose concentration in the slurry, while the pore size of scaffolds remains in the rangeot 300-500μm and the porosity maintains over 80%. According the analysis on Cellular Structure Model, it is suggested that employing high strength glass and optimizing slurry composition are effective approaches to improve cellular structure and increase scaffold strength. The compressive strength of another borosilicate glass scaffolds made from Na 2O-K 2O-MgO-CaO-SiO 2- P 2O 5-B 2O 3 system can reach 5-8MPa based on the theory. These experiments show that the replication technique is a promising way to prepare bioglass scaffolds.
Na2O-CaO-SiO2-P2O5-B2O3系硼硅酸鹽生物玻璃是一類具有良好生物活性和降解性能的組織工程材料.本研究中,采用有機泡沫浸漬法,乙醇作溶劑,乙基纖維素作添加劑,將硼硅酸鹽玻璃粉體制備成具有三維連通網狀結構的組織工程多孔支架.通過調節漿料的固相含量和乙基纖維素含量,改善坯體的涂覆量,在支架孔徑為300~500μm,孔隙率高于80%時,使支架抗壓強度從0.03MPa提高到0.36MPa.根據蜂窩狀結構模型分析,發現采用高強度玻璃,優化漿料是改善多孔材料結構和力學性能的有效途徑.用該模型理論指導,由Na2O-K2O-MgO-CaO·SiO2-P2O5-B2O3系統制成的另一種硼硅酸鹽玻璃支架,其抗壓強度可達5~8MPa.實驗表明有機泡沫浸漬法在制備組織工程支架中有廣泛的應用前景.
Persistent Identifierhttp://hdl.handle.net/10722/143145
ISSN
2015 Impact Factor: 0.551
2015 SCImago Journal Rankings: 0.204
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorYao, AHen_HK
dc.contributor.authorWang, DPen_HK
dc.contributor.authorHuang, WHen_HK
dc.contributor.authorFu, HLen_HK
dc.contributor.authorZhao, Den_HK
dc.contributor.authorLu, WJen_HK
dc.contributor.authorPan, HBen_HK
dc.date.accessioned2011-11-02T03:06:35Z-
dc.date.available2011-11-02T03:06:35Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Inorganic Materials, 2008, v. 23 n. 2, p. 322-326en_HK
dc.identifier.citation無機材料學報, 2008, v. 23 n. 2, p. 322-326-
dc.identifier.issn1000-324Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/143145-
dc.description.abstractA borosilicate bioglass in Na 2O-CaO-SiO 2-P 2O 5- B 2O 3 system is a bioactive and biodegradable material for tissue engineering. In this study, the bioactive porous scaffolds with three-dimensional interconnection were fabricated by replication technique, using borosilicate bioglass powder to form slurry with ethanol as solvent and ethyl-cellulose as additive. The compressive strength of scaffolds increases from 0.03MPa to 0.36MPa by adjusting the slurry load, the solid concentration and the ethyl-cellulose concentration in the slurry, while the pore size of scaffolds remains in the rangeot 300-500μm and the porosity maintains over 80%. According the analysis on Cellular Structure Model, it is suggested that employing high strength glass and optimizing slurry composition are effective approaches to improve cellular structure and increase scaffold strength. The compressive strength of another borosilicate glass scaffolds made from Na 2O-K 2O-MgO-CaO-SiO 2- P 2O 5-B 2O 3 system can reach 5-8MPa based on the theory. These experiments show that the replication technique is a promising way to prepare bioglass scaffolds.en_HK
dc.description.abstractNa2O-CaO-SiO2-P2O5-B2O3系硼硅酸鹽生物玻璃是一類具有良好生物活性和降解性能的組織工程材料.本研究中,采用有機泡沫浸漬法,乙醇作溶劑,乙基纖維素作添加劑,將硼硅酸鹽玻璃粉體制備成具有三維連通網狀結構的組織工程多孔支架.通過調節漿料的固相含量和乙基纖維素含量,改善坯體的涂覆量,在支架孔徑為300~500μm,孔隙率高于80%時,使支架抗壓強度從0.03MPa提高到0.36MPa.根據蜂窩狀結構模型分析,發現采用高強度玻璃,優化漿料是改善多孔材料結構和力學性能的有效途徑.用該模型理論指導,由Na2O-K2O-MgO-CaO·SiO2-P2O5-B2O3系統制成的另一種硼硅酸鹽玻璃支架,其抗壓強度可達5~8MPa.實驗表明有機泡沫浸漬法在制備組織工程支架中有廣泛的應用前景.-
dc.languagechien_US
dc.publisherScience Press (科學出版社)en_US
dc.relation.ispartofWuji Cailiao Xuebao/Journal of Inorganic Materialsen_HK
dc.relation.ispartof無機材料學報-
dc.subjectBorosilicate bioglass (硼硅酸鹽生物活性玻璃)en_HK
dc.subjectReplication technique (有機泡沫浸漬法)en_HK
dc.subjectScaffolds (多孔支架)en_HK
dc.subjectSlurry (漿料)en_HK
dc.titlePreparation of porous scaffolds of borosilicate bioglassen_HK
dc.title硼硅酸鹽生物活性玻璃多孔支架的制備-
dc.typeArticleen_HK
dc.identifier.emailLu, WJ:wwlu@hku.hken_HK
dc.identifier.emailPan, HB:haobo@hku.hken_HK
dc.identifier.authorityLu, WJ=rp00411en_HK
dc.identifier.authorityPan, HB=rp01564en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3724/SP.J.1077.2008.00322en_HK
dc.identifier.scopuseid_2-s2.0-41949109591en_HK
dc.identifier.hkuros163522-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41949109591&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue2en_HK
dc.identifier.spage322en_HK
dc.identifier.epage326en_HK
dc.publisher.placeBeijing (北京)en_HK
dc.identifier.scopusauthoridLiu, X=36064600700en_HK
dc.identifier.scopusauthoridYao, AH=15761582600en_HK
dc.identifier.scopusauthoridWang, DP=7407069947en_HK
dc.identifier.scopusauthoridHuang, WH=7407905904en_HK
dc.identifier.scopusauthoridFu, HL=15759505300en_HK
dc.identifier.scopusauthoridZhao, D=35225599700en_HK
dc.identifier.scopusauthoridLu, WJ=7404215221en_HK
dc.identifier.scopusauthoridPan, HB=7403295092en_HK
dc.customcontrol.immutablecsl 140625-

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