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Article: Calcium phosphate solubility: The need for re-evaluation

TitleCalcium phosphate solubility: The need for re-evaluation
Authors
Issue Date2009
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/crystal
Citation
Crystal Growth And Design, 2009, v. 9 n. 2, p. 639-645 How to Cite?
Abstract
The determination of the solubility of calcium phosphates by the conventional large excess of solid method has been demonstrated to be inappropriate. The problem lies in incongruent dissolution, leading to phase transformations, and lack of detailed solution equilibria: all calculations have been based on simplifications, which are only crudely approximate. The absolute solid-titration approach shows excellent reliability and reproducibility. Using solid titration, the true solubility isotherm of hydroxyapatite (HAp) has been found to lie substantially lower than previously reported. In addition, contrary to wide belief, dicalcium phosphate dihydrate (DCPD) is not the most stable phase below pH ∼4.2, where calcium-deficient HAp is less soluble. The misunderstanding here arises from the metastability of DCPD, which nucleates much more easily than HAp at low pH. Such results indicate that the Ca-P system is in need of complete reappraisal. The solid-titration method can be extended to other complex systems. © 2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/143143
ISSN
2013 Impact Factor: 4.558
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorPan, HBen_HK
dc.contributor.authorDarvell, BWen_HK
dc.date.accessioned2011-11-02T03:06:30Z-
dc.date.available2011-11-02T03:06:30Z-
dc.date.issued2009en_HK
dc.identifier.citationCrystal Growth And Design, 2009, v. 9 n. 2, p. 639-645en_HK
dc.identifier.issn1528-7483en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143143-
dc.description.abstractThe determination of the solubility of calcium phosphates by the conventional large excess of solid method has been demonstrated to be inappropriate. The problem lies in incongruent dissolution, leading to phase transformations, and lack of detailed solution equilibria: all calculations have been based on simplifications, which are only crudely approximate. The absolute solid-titration approach shows excellent reliability and reproducibility. Using solid titration, the true solubility isotherm of hydroxyapatite (HAp) has been found to lie substantially lower than previously reported. In addition, contrary to wide belief, dicalcium phosphate dihydrate (DCPD) is not the most stable phase below pH ∼4.2, where calcium-deficient HAp is less soluble. The misunderstanding here arises from the metastability of DCPD, which nucleates much more easily than HAp at low pH. Such results indicate that the Ca-P system is in need of complete reappraisal. The solid-titration method can be extended to other complex systems. © 2009 American Chemical Society.en_HK
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/crystalen_HK
dc.relation.ispartofCrystal Growth and Designen_HK
dc.titleCalcium phosphate solubility: The need for re-evaluationen_HK
dc.typeArticleen_HK
dc.identifier.emailPan, HB: haobo@hku.hken_HK
dc.identifier.emailDarvell, BW: b.w.darvell@hku.hken_HK
dc.identifier.authorityPan, HB=rp01564en_HK
dc.identifier.authorityDarvell, BW=rp00007en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/cg801118v-
dc.identifier.scopuseid_2-s2.0-61749093731en_HK
dc.identifier.hkuros163517-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61749093731&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue2en_HK
dc.identifier.spage639en_HK
dc.identifier.epage645en_HK
dc.identifier.eissn1528-7505-
dc.identifier.isiWOS:000263048200001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPan, HB=7403295092en_HK
dc.identifier.scopusauthoridDarvell, BW=7005953926en_HK

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