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Article: Microarchitecture and nanomechanical properties of trabecular bone after strontium administration in osteoporotic goats

TitleMicroarchitecture and nanomechanical properties of trabecular bone after strontium administration in osteoporotic goats
Authors
KeywordsBone strength
Nanoindentation
Osteoporosis
Ovariectomized goats
Strontium
Issue Date2012
PublisherHumana Press, Inc
Citation
Biological Trace Element Research, 2012, v. 145 n. 1, p. 39-46 How to Cite?
AbstractStrontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18 osteoporotic goats were divided into four groups according to the treatment regimen: control, calcium alone (Ca), calcium and Sr at 24 mg/kg (Ca + 24Sr), and calcium and Sr at 40 mg/kg (Ca + 40Sr). The effects of Sr administration on bone microarchitecture and nanomechanical properties of trabecular bones were analyzed with micro-CT and nanoindentation test, respectively. Serum Sr levels increased six- and tenfold in the Ca + 24Sr and Ca + 40Sr groups, respectively. Similarly, Sr in the bone increased four- and sixfold in these two groups. Sr administration significantly increased trabecular bone volume fraction, trabecular thickness, and double-labeled new bone area. Sr administration, however, did not significantly change the nanomechanical properties of trabecular bone (elastic modulus and hardness). The data suggested that Sr administration increased trabecular bone volume and improved the microarchitecture while maintaining the intrinsic tissue properties in the osteoporotic goat model. © 2011 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/143139
ISSN
2015 Impact Factor: 1.798
2015 SCImago Journal Rankings: 0.652
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong RGCHKU 7147/07E
Hong Kong ITF FundGHP/009/06
Funding Information:

This study was partially supported by the Hong Kong RGC (HKU 7147/07E) and Hong Kong ITF Fund (GHP/009/06). The authors would like to thank Mr. Stephen Chan and Patrick Wong for their expert technical assistance in specimen preparation.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLi, Zen_HK
dc.contributor.authorPeng, Sen_HK
dc.contributor.authorPan, Hen_HK
dc.contributor.authorTang, Ben_HK
dc.contributor.authorLam, RWMen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2011-11-02T03:06:19Z-
dc.date.available2011-11-02T03:06:19Z-
dc.date.issued2012en_HK
dc.identifier.citationBiological Trace Element Research, 2012, v. 145 n. 1, p. 39-46en_HK
dc.identifier.issn0163-4984en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143139-
dc.description.abstractStrontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a bone-seeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18 osteoporotic goats were divided into four groups according to the treatment regimen: control, calcium alone (Ca), calcium and Sr at 24 mg/kg (Ca + 24Sr), and calcium and Sr at 40 mg/kg (Ca + 40Sr). The effects of Sr administration on bone microarchitecture and nanomechanical properties of trabecular bones were analyzed with micro-CT and nanoindentation test, respectively. Serum Sr levels increased six- and tenfold in the Ca + 24Sr and Ca + 40Sr groups, respectively. Similarly, Sr in the bone increased four- and sixfold in these two groups. Sr administration significantly increased trabecular bone volume fraction, trabecular thickness, and double-labeled new bone area. Sr administration, however, did not significantly change the nanomechanical properties of trabecular bone (elastic modulus and hardness). The data suggested that Sr administration increased trabecular bone volume and improved the microarchitecture while maintaining the intrinsic tissue properties in the osteoporotic goat model. © 2011 The Author(s).en_HK
dc.languageengen_US
dc.publisherHumana Press, Incen_US
dc.relation.ispartofBiological Trace Element Researchen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.subjectBone strengthen_HK
dc.subjectNanoindentationen_HK
dc.subjectOsteoporosisen_HK
dc.subjectOvariectomized goatsen_HK
dc.subjectStrontiumen_HK
dc.titleMicroarchitecture and nanomechanical properties of trabecular bone after strontium administration in osteoporotic goatsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4551/resserv?sid=springerlink&genre=article&atitle=Microarchitecture and Nanomechanical Properties of Trabecular Bone After Strontium Administration in Osteoporotic Goats&title=Biological Trace Element Research&issn=01634984&date=2012-01-01&volume=145&issue=1& spage=39&authors=Zhaoyang Li, Songlin Peng, Haobo Pan, <i>et al.</i>en_US
dc.identifier.emailPan, H: haobo@hku.hken_HK
dc.identifier.emailTang, B: tangbin@hkucc.hku.hken_HK
dc.identifier.emailLu, WW: wwlu@hku.hken_HK
dc.identifier.authorityPan, H=rp01564en_HK
dc.identifier.authorityTang, B=rp00081en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s12011-011-9158-yen_HK
dc.identifier.pmid21814830en_HK
dc.identifier.pmcidPMC3256317-
dc.identifier.scopuseid_2-s2.0-84857355647en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857355647&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume145en_HK
dc.identifier.issue1en_HK
dc.identifier.spage39en_HK
dc.identifier.epage46en_HK
dc.identifier.eissn1559-0720en_US
dc.identifier.isiWOS:000299090300005-
dc.publisher.placeUnited Statesen_HK
dc.description.otherSpringer Open Choice, 21 Feb 2012en_US
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications-
dc.identifier.scopusauthoridLi, Z=35867304900en_HK
dc.identifier.scopusauthoridPeng, S=13402746900en_HK
dc.identifier.scopusauthoridPan, H=7403295092en_HK
dc.identifier.scopusauthoridTang, B=24554184100en_HK
dc.identifier.scopusauthoridLam, RWM=14625371400en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.citeulike9690710-

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