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Article: Conversion of borate-based glass scaffold to hydroxyapatite in a dilute phosphate solution

TitleConversion of borate-based glass scaffold to hydroxyapatite in a dilute phosphate solution
Authors
Issue Date2010
PublisherInstitute of Physics Publishing Ltd.. The Journal's web site is located at http://www.iop.org/EJ/journal/BMM
Citation
Biomedical Materials, 2010, v. 5 n. 1, article no. 15005 How to Cite?
AbstractPorous scaffolds of a borate-based glass (composition in mol%: 6Na 2O, 8K2O, 8MgO, 22CaO, 36B2O3, 18SiO2, 2P2O5), with interconnected porosity of ∼70% and pores of size 200-500 νm, were prepared by a polymer foam replication technique. The degradation of the scaffolds and conversion to a hydroxyapatite-type material in a 0.02 M K2HPO4 solution (starting pH = 7.0) at 37 °C were studied by measuring the weight loss of the scaffolds, as well as the pH and the boron concentration of the solution. X-ray diffraction, scanning electronic microscopy and energy dispersive X-ray analysis showed that a hydroxyapatite-type material was formed on the glass surface within 7 days of immersion in the phosphate solution. Cellular response to the scaffolds was assessed using murine MLO-A5 cells, an osteogenic cell line. Scanning electron microscopy showed that the scaffolds supported cell attachment and proliferation during the 6 day incubation. The results indicate that this borate-based glass could provide a promising degradable scaffold material for bone tissue engineering applications. © 2010 IOP Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/143133
ISSN
2015 Impact Factor: 3.361
2015 SCImago Journal Rankings: 0.936
ISI Accession Number ID
Funding AgencyGrant Number
Shanghai Committee of Science and Technology08441900500
nano-technology promotion0952nm03400
Funding Information:

This work was supported by the Shanghai Committee of Science and Technology through the major project (grant no 08441900500) and the nano-technology promotion project (grant no 0952nm03400).

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorPan, Hen_HK
dc.contributor.authorFu, Hen_HK
dc.contributor.authorFu, Qen_HK
dc.contributor.authorRahaman, MNen_HK
dc.contributor.authorHuang, Wen_HK
dc.date.accessioned2011-11-02T03:05:59Z-
dc.date.available2011-11-02T03:05:59Z-
dc.date.issued2010en_HK
dc.identifier.citationBiomedical Materials, 2010, v. 5 n. 1, article no. 15005en_HK
dc.identifier.issn1748-6041en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143133-
dc.description.abstractPorous scaffolds of a borate-based glass (composition in mol%: 6Na 2O, 8K2O, 8MgO, 22CaO, 36B2O3, 18SiO2, 2P2O5), with interconnected porosity of ∼70% and pores of size 200-500 νm, were prepared by a polymer foam replication technique. The degradation of the scaffolds and conversion to a hydroxyapatite-type material in a 0.02 M K2HPO4 solution (starting pH = 7.0) at 37 °C were studied by measuring the weight loss of the scaffolds, as well as the pH and the boron concentration of the solution. X-ray diffraction, scanning electronic microscopy and energy dispersive X-ray analysis showed that a hydroxyapatite-type material was formed on the glass surface within 7 days of immersion in the phosphate solution. Cellular response to the scaffolds was assessed using murine MLO-A5 cells, an osteogenic cell line. Scanning electron microscopy showed that the scaffolds supported cell attachment and proliferation during the 6 day incubation. The results indicate that this borate-based glass could provide a promising degradable scaffold material for bone tissue engineering applications. © 2010 IOP Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherInstitute of Physics Publishing Ltd.. The Journal's web site is located at http://www.iop.org/EJ/journal/BMMen_HK
dc.relation.ispartofBiomedical Materialsen_HK
dc.titleConversion of borate-based glass scaffold to hydroxyapatite in a dilute phosphate solutionen_HK
dc.typeArticleen_HK
dc.identifier.emailPan, H:haobo@hku.hken_HK
dc.identifier.authorityPan, H=rp01564en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1088/1748-6041/5/1/015005en_HK
dc.identifier.pmid20057014-
dc.identifier.scopuseid_2-s2.0-76249123189en_HK
dc.identifier.hkuros176713-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76249123189&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue1en_HK
dc.identifier.spagearticle no. 15005-
dc.identifier.epagearticle no. 15005-
dc.identifier.eissn1748-605X-
dc.identifier.isiWOS:000274247400005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiu, X=36064600700en_HK
dc.identifier.scopusauthoridPan, H=7403295092en_HK
dc.identifier.scopusauthoridFu, H=15759505300en_HK
dc.identifier.scopusauthoridFu, Q=36046915000en_HK
dc.identifier.scopusauthoridRahaman, MN=7006601420en_HK
dc.identifier.scopusauthoridHuang, W=7407905904en_HK

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