File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Human pluripotent stem cell-based approaches for myocardial repair: From the electrophysiological perspective

TitleHuman pluripotent stem cell-based approaches for myocardial repair: From the electrophysiological perspective
Authors
KeywordsCardiomyocytes
Electrophysiology
Heart
Human Embryonic Stem Cells
Induced Pluripotent Stem Cells
Issue Date2011
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/mpohbp/index.html
Citation
Molecular Pharmaceutics, 2011, v. 8 n. 5, p. 1495-1504 How to Cite?
AbstractHeart diseases are a leading cause of mortality worldwide. Terminally differentiated adult cardiomyocytes (CMs) lack the innate ability to regenerate. Their malfunction or significant loss can lead to conditions from cardiac arrhythmias to heart failure. For myocardial repair, cell- and gene-based therapies offer promising alternatives to donor organ transplantation. Human embryonic stem cells (hESCs) can self-renew while maintaining their pluripotency. Direct reprogramming of adult somatic cells to become pluripotent hES-like cells (also known as induced pluripotent stem cells or iPSCs) has been achieved. Both hESCs and iPSCs have been successfully differentiated into genuine human CMs. In this review, we describe our current knowledge of the structure-function properties of hESC/iPSC-CMs, with an emphasis on their electrophysiology and Ca 2+ handling, along with the hurdles faced and potential solutions for translating into clinical and other applications (e.g., disease modeling, cardiotoxicity and drug screening). © 2011 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/143125
ISSN
2015 Impact Factor: 4.342
2015 SCImago Journal Rankings: 1.681
ISI Accession Number ID
Funding AgencyGrant Number
NIHR01 HL72857
Research Grant Council
CC Wong Foundation
HKU
Funding Information:

This work was supported by grants from the NIH, R01 HL72857 (to R.A.L.), Research Grant Council (to R.A.L.), the CC Wong Foundation Stem Cell Fund (to R.A.L.) and the HKU Development Fund (to E.P., C.-w.K. and R.A.L.).

References

 

DC FieldValueLanguage
dc.contributor.authorPoon, Een_HK
dc.contributor.authorKong, CWen_HK
dc.contributor.authorLi, RAen_HK
dc.date.accessioned2011-11-02T03:05:23Z-
dc.date.available2011-11-02T03:05:23Z-
dc.date.issued2011en_HK
dc.identifier.citationMolecular Pharmaceutics, 2011, v. 8 n. 5, p. 1495-1504en_HK
dc.identifier.issn1543-8384en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143125-
dc.description.abstractHeart diseases are a leading cause of mortality worldwide. Terminally differentiated adult cardiomyocytes (CMs) lack the innate ability to regenerate. Their malfunction or significant loss can lead to conditions from cardiac arrhythmias to heart failure. For myocardial repair, cell- and gene-based therapies offer promising alternatives to donor organ transplantation. Human embryonic stem cells (hESCs) can self-renew while maintaining their pluripotency. Direct reprogramming of adult somatic cells to become pluripotent hES-like cells (also known as induced pluripotent stem cells or iPSCs) has been achieved. Both hESCs and iPSCs have been successfully differentiated into genuine human CMs. In this review, we describe our current knowledge of the structure-function properties of hESC/iPSC-CMs, with an emphasis on their electrophysiology and Ca 2+ handling, along with the hurdles faced and potential solutions for translating into clinical and other applications (e.g., disease modeling, cardiotoxicity and drug screening). © 2011 American Chemical Society.en_HK
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/mpohbp/index.htmlen_HK
dc.relation.ispartofMolecular Pharmaceuticsen_HK
dc.subjectCardiomyocytesen_US
dc.subjectElectrophysiologyen_US
dc.subjectHearten_US
dc.subjectHuman Embryonic Stem Cellsen_US
dc.subjectInduced Pluripotent Stem Cellsen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshElectrophysiological Phenomenaen_HK
dc.subject.meshEmbryonic Stem Cells - physiology - transplantationen_HK
dc.subject.meshHeart - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInduced Pluripotent Stem Cells - physiology - transplantationen_HK
dc.subject.meshMicroRNAs - metabolismen_HK
dc.subject.meshMuscle Developmenten_HK
dc.subject.meshMyocardial Infarction - metabolism - rehabilitation - therapyen_HK
dc.subject.meshMyocytes, Cardiac - physiologyen_HK
dc.subject.meshPluripotent Stem Cells - metabolism - transplantationen_HK
dc.subject.meshRegenerationen_HK
dc.subject.meshSinoatrial Node - physiologyen_HK
dc.subject.meshTissue Engineeringen_HK
dc.titleHuman pluripotent stem cell-based approaches for myocardial repair: From the electrophysiological perspectiveen_HK
dc.typeArticleen_HK
dc.identifier.emailKong, CW:marcokong@hku.hken_HK
dc.identifier.emailLi, RA:ronaldli@hkucc.hku.hken_HK
dc.identifier.authorityKong, CW=rp01563en_HK
dc.identifier.authorityLi, RA=rp01352en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1021/mp2002363en_HK
dc.identifier.pmid21879736-
dc.identifier.scopuseid_2-s2.0-80053466698en_HK
dc.identifier.hkuros212189-
dc.identifier.hkuros197133-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053466698&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1495en_HK
dc.identifier.epage1504en_HK
dc.identifier.eissn1543-8392-
dc.identifier.isiWOS:000295347500007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPoon, E=53871816200en_HK
dc.identifier.scopusauthoridKong, CW=36784634200en_HK
dc.identifier.scopusauthoridLi, RA=7404724466en_HK
dc.identifier.citeulike9856752-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats