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Article: Ophthalmic manifestations and risk factors for mortality of HIV patients in the post-highly active anti-retroviral therapy era

TitleOphthalmic manifestations and risk factors for mortality of HIV patients in the post-highly active anti-retroviral therapy era
Authors
KeywordsAIDS
CMV retinitis
Factor
HIV
Mortality
Risk
Issue Date2011
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEO
Citation
Clinical And Experimental Ophthalmology, 2011, v. 39 n. 2, p. 99-104 How to Cite?
AbstractBackground: To evaluate the ophthalmic manifestations and risk factors for mortality in HIV patients in the post-highly active anti-retrovirus therapy (HAART) era. Design: Retrospective study. Samples: 151 patients with HIV infection. Methods: Review of all HIV patients who have attended the Hong Kong Eye Hospital between 2000 and 2007. Main Outcome Measures: Ocular findings especially opportunistic infections and medical information including mortality during follow up. Results: At presentation, 139 (92.1%) patients were already diagnosed with HIV and 58 (41.7%) had an AIDS indicator condition. Fifty-one (33.8%) patients had HIV-related eye disease on presentation and the leading manifestations were cytomegalovirus (CMV) retinitis and HIV microangiopathy. Low baseline CD4 cell count <100 cells/L was significantly related with HIV-related ophthalmic manifestations and CMV retinitis at presentation (P<0.013). 105 patients were followed for 6 months or more and the mean follow-up was 4.8 years. There was no significant change in visual acuity compared with baseline (P=0.13). 20 (19.0%) patients had one eye with final visual acuity of 20/200 or worse and the leading cause for poor vision was CMV retinitis. 11 (10.5%) patients died during the follow-up due to complications of HIV/AIDS. The presence of HIV retinal microangiopathy was significantly associated with mortality (P=0.005). Conclusions: CMV retinitis remains the main HIV-related ocular disease in the post-HAART era. HIV retinal microangiopathy might be an important prognostic factor for mortality. Appropriate ophthalmic monitoring is justified to detect for ophthalmic complications in HIV patients regardless of HAART use in order for prompt initiation of treatment. © 2010 The Authors. Clinical and Experimental Ophthalmology © 2010 Royal Australian and New Zealand College of Ophthalmologists.
Persistent Identifierhttp://hdl.handle.net/10722/143001
ISSN
2015 Impact Factor: 2.546
2015 SCImago Journal Rankings: 1.335
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, TYYen_HK
dc.contributor.authorWong, RLen_HK
dc.contributor.authorLuk, FOen_HK
dc.contributor.authorChow, VWen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorLam, DSen_HK
dc.date.accessioned2011-10-28T03:02:05Z-
dc.date.available2011-10-28T03:02:05Z-
dc.date.issued2011en_HK
dc.identifier.citationClinical And Experimental Ophthalmology, 2011, v. 39 n. 2, p. 99-104en_HK
dc.identifier.issn1442-6404en_HK
dc.identifier.urihttp://hdl.handle.net/10722/143001-
dc.description.abstractBackground: To evaluate the ophthalmic manifestations and risk factors for mortality in HIV patients in the post-highly active anti-retrovirus therapy (HAART) era. Design: Retrospective study. Samples: 151 patients with HIV infection. Methods: Review of all HIV patients who have attended the Hong Kong Eye Hospital between 2000 and 2007. Main Outcome Measures: Ocular findings especially opportunistic infections and medical information including mortality during follow up. Results: At presentation, 139 (92.1%) patients were already diagnosed with HIV and 58 (41.7%) had an AIDS indicator condition. Fifty-one (33.8%) patients had HIV-related eye disease on presentation and the leading manifestations were cytomegalovirus (CMV) retinitis and HIV microangiopathy. Low baseline CD4 cell count <100 cells/L was significantly related with HIV-related ophthalmic manifestations and CMV retinitis at presentation (P<0.013). 105 patients were followed for 6 months or more and the mean follow-up was 4.8 years. There was no significant change in visual acuity compared with baseline (P=0.13). 20 (19.0%) patients had one eye with final visual acuity of 20/200 or worse and the leading cause for poor vision was CMV retinitis. 11 (10.5%) patients died during the follow-up due to complications of HIV/AIDS. The presence of HIV retinal microangiopathy was significantly associated with mortality (P=0.005). Conclusions: CMV retinitis remains the main HIV-related ocular disease in the post-HAART era. HIV retinal microangiopathy might be an important prognostic factor for mortality. Appropriate ophthalmic monitoring is justified to detect for ophthalmic complications in HIV patients regardless of HAART use in order for prompt initiation of treatment. © 2010 The Authors. Clinical and Experimental Ophthalmology © 2010 Royal Australian and New Zealand College of Ophthalmologists.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEOen_HK
dc.relation.ispartofClinical and Experimental Ophthalmologyen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.comen_US
dc.subjectAIDSen_HK
dc.subjectCMV retinitisen_HK
dc.subjectFactoren_HK
dc.subjectHIVen_HK
dc.subjectMortalityen_HK
dc.subjectRisken_HK
dc.subject.meshAIDS-Related Opportunistic Infections - drug therapy - mortality - virology-
dc.subject.meshAntiretroviral Therapy, Highly Active-
dc.subject.meshCytomegalovirus Retinitis - mortality - virology-
dc.subject.meshEye Infections, Viral - drug therapy - mortality - virology-
dc.subject.meshHIV Protease Inhibitors - therapeutic use-
dc.titleOphthalmic manifestations and risk factors for mortality of HIV patients in the post-highly active anti-retroviral therapy eraen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, RLM: ray81@hku.hken_US
dc.identifier.authorityWong, RLM=rp01394en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1442-9071.2010.02400.xen_HK
dc.identifier.pmid20796263-
dc.identifier.scopuseid_2-s2.0-79952646541en_HK
dc.identifier.hkuros197017en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952646541&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue2en_HK
dc.identifier.spage99en_HK
dc.identifier.epage104en_HK
dc.identifier.isiWOS:000288458800003-
dc.publisher.placeAustraliaen_HK
dc.identifier.citeulike9031719-

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