Article: The 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinoma
| Title | The 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinoma | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Zhu, X4 5 Wang, F3 Lin, MCM2 Tian, L5 Fan, W3 Ng, SS1 Liu, M4 Huang, J4 Xu, Z2 Li, D3 Kung, H3 5 | ||||||
| Issue Date | 2011 | ||||||
| Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | ||||||
| Citation | Plos One, 2011, v. 6 n. 3 [How to Cite?] DOI: http://dx.doi.org/10.1371/journal.pone.0017783 | ||||||
| Abstract | Background: Elevated glucose-regulated protein 78 (GRP78) levels in tissues have been known to be related with poor prognosis in hepatocellular carcinoma (HCC) patients. Though the variants in the 3′ untranslated region (UTR) of GRP78 gene were not associated with HCC risk, we wonder whether these polymorphisms affect survival of HCC patients. Methodology/Principal Findings: Blood samples of HCC patients were maintained in our specimen bank between 1996 to 2003. DNA from 576 unrelated and resectable patients with HCC was typed for rs16927997 (T>C), rs1140763 (T>C) and rs12009 (T>C) by TaqMan assays. The Kaplan-Meier method and log-rank test were used to estimate overall survival. Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distribution of haplotype was not related to the clinical characteristics. Univariate analysis showed that the allele, genotype, haplotype and diplotype did not effect the survival. None of the clinical features show a significant association (P correced>0.05) with overall patient outcome in multiple comparisons. Conclusions/Significance: There is no noteworthy influence of 3′ UTR variants in the GRP78 on prognosis of resectable HCC in the Chinese population. © 2011 Zhu et al. | ||||||
| ISSN | 1932-6203 2011 Impact Factor: 4.092 2011 SCImago Journal Rankings: 0.519 | ||||||
| DOI | http://dx.doi.org/10.1371/journal.pone.0017783 | ||||||
| ISI Accession Number ID | WOS:000288809100008
Funding Information: This work was supported by the National Nature Science Foundation of China ( Grant No. 81071697) and the Research Project of Health Bureau of Guangzhou City (Grant No. 201102A213005). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ||||||
| PubMed Central ID | PMC3062561 | ||||||
| References | References in Scopus |
| dc.contributor.author | Zhu, X | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Wang, F | ||||||
| dc.contributor.author | Lin, MCM | ||||||
| dc.contributor.author | Tian, L | ||||||
| dc.contributor.author | Fan, W | ||||||
| dc.contributor.author | Ng, SS | ||||||
| dc.contributor.author | Liu, M | ||||||
| dc.contributor.author | Huang, J | ||||||
| dc.contributor.author | Xu, Z | ||||||
| dc.contributor.author | Li, D | ||||||
| dc.contributor.author | Kung, H | ||||||
| dc.date.accessioned | 2011-10-28T03:00:27Z | ||||||
| dc.date.available | 2011-10-28T03:00:27Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Background: Elevated glucose-regulated protein 78 (GRP78) levels in tissues have been known to be related with poor prognosis in hepatocellular carcinoma (HCC) patients. Though the variants in the 3′ untranslated region (UTR) of GRP78 gene were not associated with HCC risk, we wonder whether these polymorphisms affect survival of HCC patients. Methodology/Principal Findings: Blood samples of HCC patients were maintained in our specimen bank between 1996 to 2003. DNA from 576 unrelated and resectable patients with HCC was typed for rs16927997 (T>C), rs1140763 (T>C) and rs12009 (T>C) by TaqMan assays. The Kaplan-Meier method and log-rank test were used to estimate overall survival. Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distribution of haplotype was not related to the clinical characteristics. Univariate analysis showed that the allele, genotype, haplotype and diplotype did not effect the survival. None of the clinical features show a significant association (P correced>0.05) with overall patient outcome in multiple comparisons. Conclusions/Significance: There is no noteworthy influence of 3′ UTR variants in the GRP78 on prognosis of resectable HCC in the Chinese population. © 2011 Zhu et al. | ||||||
| dc.description.nature | published_or_final_version | ||||||
| dc.identifier.citation | Plos One, 2011, v. 6 n. 3 [How to Cite?] DOI: http://dx.doi.org/10.1371/journal.pone.0017783 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0017783 | ||||||
| dc.identifier.epage | e17783 | ||||||
| dc.identifier.hkuros | 196603 | ||||||
| dc.identifier.isi | WOS:000288809100008
Funding Information: This work was supported by the National Nature Science Foundation of China ( Grant No. 81071697) and the Research Project of Health Bureau of Guangzhou City (Grant No. 201102A213005). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ||||||
| dc.identifier.issn | 1932-6203 2011 Impact Factor: 4.092 2011 SCImago Journal Rankings: 0.519 | ||||||
| dc.identifier.issue | 3 | ||||||
| dc.identifier.pmcid | PMC3062561 | ||||||
| dc.identifier.pmid | 21445355 | ||||||
| dc.identifier.scopus | eid_2-s2.0-79952943508 | ||||||
| dc.identifier.spage | e17783 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/142971 | ||||||
| dc.identifier.volume | 6 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | PLoS ONE | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License | ||||||
| dc.subject.mesh | 3' Untranslated Regions | ||||||
| dc.subject.mesh | Carcinoma, Hepatocellular - genetics - metabolism - pathology | ||||||
| dc.subject.mesh | Heat-Shock Proteins - genetics | ||||||
| dc.subject.mesh | Liver Neoplasms - genetics - metabolism - pathology | ||||||
| dc.subject.mesh | Survival Analysis | ||||||
| dc.title | The 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinoma | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Prince of Wales Hospital Hong Kong
- Sun Yat-Sen University
- Guangzhou Medical College
- Chinese University of Hong Kong