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Article: The 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinoma
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TitleThe 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinoma
 
AuthorsZhu, X5 4
Wang, F3
Lin, MCM2
Tian, L5
Fan, W3
Ng, SS1
Liu, M4
Huang, J4
Xu, Z2
Li, D3
Kung, H5 3
 
Issue Date2011
 
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
CitationPlos One, 2011, v. 6 n. 3 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0017783
 
AbstractBackground: Elevated glucose-regulated protein 78 (GRP78) levels in tissues have been known to be related with poor prognosis in hepatocellular carcinoma (HCC) patients. Though the variants in the 3′ untranslated region (UTR) of GRP78 gene were not associated with HCC risk, we wonder whether these polymorphisms affect survival of HCC patients. Methodology/Principal Findings: Blood samples of HCC patients were maintained in our specimen bank between 1996 to 2003. DNA from 576 unrelated and resectable patients with HCC was typed for rs16927997 (T>C), rs1140763 (T>C) and rs12009 (T>C) by TaqMan assays. The Kaplan-Meier method and log-rank test were used to estimate overall survival. Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distribution of haplotype was not related to the clinical characteristics. Univariate analysis showed that the allele, genotype, haplotype and diplotype did not effect the survival. None of the clinical features show a significant association (P correced>0.05) with overall patient outcome in multiple comparisons. Conclusions/Significance: There is no noteworthy influence of 3′ UTR variants in the GRP78 on prognosis of resectable HCC in the Chinese population. © 2011 Zhu et al.
 
ISSN1932-6203
2012 Impact Factor: 3.73
2012 SCImago Journal Rankings: 1.512
 
DOIhttp://dx.doi.org/10.1371/journal.pone.0017783
 
PubMed Central IDPMC3062561
 
ISI Accession Number IDWOS:000288809100008
Funding AgencyGrant Number
National Nature Science Foundation of China81071697
Research Project of Health Bureau of Guangzhou City201102A213005
Funding Information:

This work was supported by the National Nature Science Foundation of China ( Grant No. 81071697) and the Research Project of Health Bureau of Guangzhou City (Grant No. 201102A213005). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhu, X
 
dc.contributor.authorWang, F
 
dc.contributor.authorLin, MCM
 
dc.contributor.authorTian, L
 
dc.contributor.authorFan, W
 
dc.contributor.authorNg, SS
 
dc.contributor.authorLiu, M
 
dc.contributor.authorHuang, J
 
dc.contributor.authorXu, Z
 
dc.contributor.authorLi, D
 
dc.contributor.authorKung, H
 
dc.date.accessioned2011-10-28T03:00:27Z
 
dc.date.available2011-10-28T03:00:27Z
 
dc.date.issued2011
 
dc.description.abstractBackground: Elevated glucose-regulated protein 78 (GRP78) levels in tissues have been known to be related with poor prognosis in hepatocellular carcinoma (HCC) patients. Though the variants in the 3′ untranslated region (UTR) of GRP78 gene were not associated with HCC risk, we wonder whether these polymorphisms affect survival of HCC patients. Methodology/Principal Findings: Blood samples of HCC patients were maintained in our specimen bank between 1996 to 2003. DNA from 576 unrelated and resectable patients with HCC was typed for rs16927997 (T>C), rs1140763 (T>C) and rs12009 (T>C) by TaqMan assays. The Kaplan-Meier method and log-rank test were used to estimate overall survival. Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distribution of haplotype was not related to the clinical characteristics. Univariate analysis showed that the allele, genotype, haplotype and diplotype did not effect the survival. None of the clinical features show a significant association (P correced>0.05) with overall patient outcome in multiple comparisons. Conclusions/Significance: There is no noteworthy influence of 3′ UTR variants in the GRP78 on prognosis of resectable HCC in the Chinese population. © 2011 Zhu et al.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPlos One, 2011, v. 6 n. 3 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0017783
 
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0017783
 
dc.identifier.epagee17783
 
dc.identifier.hkuros196603
 
dc.identifier.isiWOS:000288809100008
Funding AgencyGrant Number
National Nature Science Foundation of China81071697
Research Project of Health Bureau of Guangzhou City201102A213005
Funding Information:

This work was supported by the National Nature Science Foundation of China ( Grant No. 81071697) and the Research Project of Health Bureau of Guangzhou City (Grant No. 201102A213005). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 
dc.identifier.issn1932-6203
2012 Impact Factor: 3.73
2012 SCImago Journal Rankings: 1.512
 
dc.identifier.issue3
 
dc.identifier.pmcidPMC3062561
 
dc.identifier.pmid21445355
 
dc.identifier.scopuseid_2-s2.0-79952943508
 
dc.identifier.spagee17783
 
dc.identifier.urihttp://hdl.handle.net/10722/142971
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPLoS ONE
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.mesh3' Untranslated Regions
 
dc.subject.meshCarcinoma, Hepatocellular - genetics - metabolism - pathology
 
dc.subject.meshHeat-Shock Proteins - genetics
 
dc.subject.meshLiver Neoplasms - genetics - metabolism - pathology
 
dc.subject.meshSurvival Analysis
 
dc.titleThe 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinoma
 
dc.typeArticle
 
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<contributor.author>Wang, F</contributor.author>
<contributor.author>Lin, MCM</contributor.author>
<contributor.author>Tian, L</contributor.author>
<contributor.author>Fan, W</contributor.author>
<contributor.author>Ng, SS</contributor.author>
<contributor.author>Liu, M</contributor.author>
<contributor.author>Huang, J</contributor.author>
<contributor.author>Xu, Z</contributor.author>
<contributor.author>Li, D</contributor.author>
<contributor.author>Kung, H</contributor.author>
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<description.abstract>Background: Elevated glucose-regulated protein 78 (GRP78) levels in tissues have been known to be related with poor prognosis in hepatocellular carcinoma (HCC) patients. Though the variants in the 3&#8242; untranslated region (UTR) of GRP78 gene were not associated with HCC risk, we wonder whether these polymorphisms affect survival of HCC patients. Methodology/Principal Findings: Blood samples of HCC patients were maintained in our specimen bank between 1996 to 2003. DNA from 576 unrelated and resectable patients with HCC was typed for rs16927997 (T&gt;C), rs1140763 (T&gt;C) and rs12009 (T&gt;C) by TaqMan assays. The Kaplan-Meier method and log-rank test were used to estimate overall survival. Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distribution of haplotype was not related to the clinical characteristics. Univariate analysis showed that the allele, genotype, haplotype and diplotype did not effect the survival. None of the clinical features show a significant association (P correced&gt;0.05) with overall patient outcome in multiple comparisons. Conclusions/Significance: There is no noteworthy influence of 3&#8242; UTR variants in the GRP78 on prognosis of resectable HCC in the Chinese population. &#169; 2011 Zhu et al.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Prince of Wales Hospital Hong Kong
  3. Sun Yat-Sen University
  4. Guangzhou Medical College
  5. Chinese University of Hong Kong