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Article: The 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinoma

TitleThe 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinoma
Authors
Issue Date2011
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2011, v. 6 n. 3 How to Cite?
Abstract
Background: Elevated glucose-regulated protein 78 (GRP78) levels in tissues have been known to be related with poor prognosis in hepatocellular carcinoma (HCC) patients. Though the variants in the 3′ untranslated region (UTR) of GRP78 gene were not associated with HCC risk, we wonder whether these polymorphisms affect survival of HCC patients. Methodology/Principal Findings: Blood samples of HCC patients were maintained in our specimen bank between 1996 to 2003. DNA from 576 unrelated and resectable patients with HCC was typed for rs16927997 (T>C), rs1140763 (T>C) and rs12009 (T>C) by TaqMan assays. The Kaplan-Meier method and log-rank test were used to estimate overall survival. Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distribution of haplotype was not related to the clinical characteristics. Univariate analysis showed that the allele, genotype, haplotype and diplotype did not effect the survival. None of the clinical features show a significant association (P correced>0.05) with overall patient outcome in multiple comparisons. Conclusions/Significance: There is no noteworthy influence of 3′ UTR variants in the GRP78 on prognosis of resectable HCC in the Chinese population. © 2011 Zhu et al.
Persistent Identifierhttp://hdl.handle.net/10722/142971
ISSN
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Nature Science Foundation of China81071697
Research Project of Health Bureau of Guangzhou City201102A213005
Funding Information:

This work was supported by the National Nature Science Foundation of China ( Grant No. 81071697) and the Research Project of Health Bureau of Guangzhou City (Grant No. 201102A213005). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorZhu, Xen_HK
dc.contributor.authorWang, Fen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorTian, Len_HK
dc.contributor.authorFan, Wen_HK
dc.contributor.authorNg, SSen_HK
dc.contributor.authorLiu, Men_HK
dc.contributor.authorHuang, Jen_HK
dc.contributor.authorXu, Zen_HK
dc.contributor.authorLi, Den_HK
dc.contributor.authorKung, Hen_HK
dc.date.accessioned2011-10-28T03:00:27Z-
dc.date.available2011-10-28T03:00:27Z-
dc.date.issued2011en_HK
dc.identifier.citationPlos One, 2011, v. 6 n. 3en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142971-
dc.description.abstractBackground: Elevated glucose-regulated protein 78 (GRP78) levels in tissues have been known to be related with poor prognosis in hepatocellular carcinoma (HCC) patients. Though the variants in the 3′ untranslated region (UTR) of GRP78 gene were not associated with HCC risk, we wonder whether these polymorphisms affect survival of HCC patients. Methodology/Principal Findings: Blood samples of HCC patients were maintained in our specimen bank between 1996 to 2003. DNA from 576 unrelated and resectable patients with HCC was typed for rs16927997 (T>C), rs1140763 (T>C) and rs12009 (T>C) by TaqMan assays. The Kaplan-Meier method and log-rank test were used to estimate overall survival. Linkage disequilibrium (LD) analysis identified a total of 3 haplotypes and 6 diplotypes in this region. The distribution of haplotype was not related to the clinical characteristics. Univariate analysis showed that the allele, genotype, haplotype and diplotype did not effect the survival. None of the clinical features show a significant association (P correced>0.05) with overall patient outcome in multiple comparisons. Conclusions/Significance: There is no noteworthy influence of 3′ UTR variants in the GRP78 on prognosis of resectable HCC in the Chinese population. © 2011 Zhu et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.mesh3' Untranslated Regions-
dc.subject.meshCarcinoma, Hepatocellular - genetics - metabolism - pathology-
dc.subject.meshHeat-Shock Proteins - genetics-
dc.subject.meshLiver Neoplasms - genetics - metabolism - pathology-
dc.subject.meshSurvival Analysis-
dc.titleThe 3′ UTR variants in the GRP78 are not associated with overall survival in resectable hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailLin, MCM: mcllin@hkucc.hku.hken_HK
dc.identifier.emailNg, SS: ssmng@hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.identifier.authorityNg, SS=rp00767en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0017783en_HK
dc.identifier.pmid21445355-
dc.identifier.pmcidPMC3062561-
dc.identifier.scopuseid_2-s2.0-79952943508en_HK
dc.identifier.hkuros196603en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952943508&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue3en_HK
dc.identifier.spagee17783en_US
dc.identifier.epagee17783en_US
dc.identifier.isiWOS:000288809100008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhu, X=23491117800en_HK
dc.identifier.scopusauthoridWang, F=35451941500en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridTian, L=7202296490en_HK
dc.identifier.scopusauthoridFan, W=24070406000en_HK
dc.identifier.scopusauthoridNg, SS=7403358718en_HK
dc.identifier.scopusauthoridLiu, M=7406298159en_HK
dc.identifier.scopusauthoridHuang, J=44861198300en_HK
dc.identifier.scopusauthoridXu, Z=44862008100en_HK
dc.identifier.scopusauthoridLi, D=24463373900en_HK
dc.identifier.scopusauthoridKung, H=7402514190en_HK

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