Article: Arterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleArterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD
AuthorsXu, L1 2
Jiang, CQ2
Lam, TH1
Yue, XJ2
Lin, JM2
Cheng, KK3
Liu, B2
Li Jin, Y2
Zhang, WS2
Thomas, GN3
Keywordsarterial stiffness
brachial-ankle pulse wave velocity
diastolic dysfunction
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
CitationJournal Of Human Hypertension, 2011, v. 25 n. 3, p. 152-158 [How to Cite?]
DOI: http://dx.doi.org/10.1038/jhh.2010.44
AbstractBrachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, is an established cardiovascular risk factor of ventricular stiffening. We studied the association of baPWV with left-ventricular (LV) diastolic function in a sub-study of the Guangzhou Biobank Cohort Study. In all, 378 Chinese subjects with a normal ejection fraction (50%) had baPWV measurement by a noninvasive automatic waveform analyser, carotid intima-medial thickness (IMT) measurement by B-mode ultrasonography and cardiac diastolic function assessment by echocardiography. After adjusting for age, both baPWV and IMT were associated with LV mass index, posterior wall end-diastolic thickness and inter-ventricular end-diastolic thickness, but only baPWV was associated with deceleration time, atrial flow velocity and E/A ratio. Multivariable linear regression model showed that baPWV and mean arterial pressure, but not IMT, were significantly associated with E/A ratio (Β=-0.02, P=0.03 and Β=-0.36, P=0.02, respectively). The receiver operator characteristic curve showed that baPWV was better than pulse pressure or mean arterial pressure to detect LV diastolic dysfunction (E/A<1.0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction. © 2011 Macmillan Publishers Limited All rights reserved.
ISSN0950-9240
2011 Impact Factor: 2.802
2011 SCImago Journal Rankings: 0.206
DOIhttp://dx.doi.org/10.1038/jhh.2010.44
ISI Accession Number IDWOS:000287195400003
Funding AgencyGrant Number
National Natural Science of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science of China/Research Grants Council (No. 30518001; HKU720/05) Grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (co-PI); The University of Hong Kong: Tai Hing Lam (co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Bernard MY Cheung, Shahrad Taheri, Paramjit Gill, Greg YH Lip, Kar Keung Cheng, G Neil Thomas (co-PI).

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorXu, L
dc.contributor.authorJiang, CQ
dc.contributor.authorLam, TH
dc.contributor.authorYue, XJ
dc.contributor.authorLin, JM
dc.contributor.authorCheng, KK
dc.contributor.authorLiu, B
dc.contributor.authorLi Jin, Y
dc.contributor.authorZhang, WS
dc.contributor.authorThomas, GN
dc.date.accessioned2011-10-28T02:51:45Z
dc.date.available2011-10-28T02:51:45Z
dc.date.issued2011
dc.description.abstractBrachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, is an established cardiovascular risk factor of ventricular stiffening. We studied the association of baPWV with left-ventricular (LV) diastolic function in a sub-study of the Guangzhou Biobank Cohort Study. In all, 378 Chinese subjects with a normal ejection fraction (50%) had baPWV measurement by a noninvasive automatic waveform analyser, carotid intima-medial thickness (IMT) measurement by B-mode ultrasonography and cardiac diastolic function assessment by echocardiography. After adjusting for age, both baPWV and IMT were associated with LV mass index, posterior wall end-diastolic thickness and inter-ventricular end-diastolic thickness, but only baPWV was associated with deceleration time, atrial flow velocity and E/A ratio. Multivariable linear regression model showed that baPWV and mean arterial pressure, but not IMT, were significantly associated with E/A ratio (Β=-0.02, P=0.03 and Β=-0.36, P=0.02, respectively). The receiver operator characteristic curve showed that baPWV was better than pulse pressure or mean arterial pressure to detect LV diastolic dysfunction (E/A<1.0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction. © 2011 Macmillan Publishers Limited All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Human Hypertension, 2011, v. 25 n. 3, p. 152-158 [How to Cite?]
DOI: http://dx.doi.org/10.1038/jhh.2010.44
dc.identifier.citeulike7114758
dc.identifier.doihttp://dx.doi.org/10.1038/jhh.2010.44
dc.identifier.epage158
dc.identifier.hkuros184528
dc.identifier.isiWOS:000287195400003
Funding AgencyGrant Number
National Natural Science of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science of China/Research Grants Council (No. 30518001; HKU720/05) Grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (co-PI); The University of Hong Kong: Tai Hing Lam (co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Bernard MY Cheung, Shahrad Taheri, Paramjit Gill, Greg YH Lip, Kar Keung Cheng, G Neil Thomas (co-PI).

dc.identifier.issn0950-9240
2011 Impact Factor: 2.802
2011 SCImago Journal Rankings: 0.206
dc.identifier.issue3
dc.identifier.pmid20428193
dc.identifier.scopuseid_2-s2.0-79951682810
dc.identifier.spage152
dc.identifier.urihttp://hdl.handle.net/10722/142573
dc.identifier.volume25
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
dc.publisher.placeUnited Kingdom
dc.relation.ispartofJournal of Human Hypertension
dc.relation.referencesReferences in Scopus
dc.subject.meshAnkle Brachial Index
dc.subject.meshCarotid Artery Diseases - epidemiology - physiopathology - ultrasonography
dc.subject.meshHeart Ventricles - physiopathology
dc.subject.meshHypertension - epidemiology - physiopathology - ultrasonography
dc.subject.meshVascular Resistance - physiology
dc.subjectarterial stiffness
dc.subjectbrachial-ankle pulse wave velocity
dc.subjectdiastolic dysfunction
dc.titleArterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Guangzhou No. 12 Hospital
  3. University of Birmingham