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Article: Arterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD

TitleArterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD
Authors
Keywordsarterial stiffness
brachial-ankle pulse wave velocity
diastolic dysfunction
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
Citation
Journal Of Human Hypertension, 2011, v. 25 n. 3, p. 152-158 How to Cite?
Abstract
Brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, is an established cardiovascular risk factor of ventricular stiffening. We studied the association of baPWV with left-ventricular (LV) diastolic function in a sub-study of the Guangzhou Biobank Cohort Study. In all, 378 Chinese subjects with a normal ejection fraction (50%) had baPWV measurement by a noninvasive automatic waveform analyser, carotid intima-medial thickness (IMT) measurement by B-mode ultrasonography and cardiac diastolic function assessment by echocardiography. After adjusting for age, both baPWV and IMT were associated with LV mass index, posterior wall end-diastolic thickness and inter-ventricular end-diastolic thickness, but only baPWV was associated with deceleration time, atrial flow velocity and E/A ratio. Multivariable linear regression model showed that baPWV and mean arterial pressure, but not IMT, were significantly associated with E/A ratio (Β=-0.02, P=0.03 and Β=-0.36, P=0.02, respectively). The receiver operator characteristic curve showed that baPWV was better than pulse pressure or mean arterial pressure to detect LV diastolic dysfunction (E/A<1.0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction. © 2011 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/142573
ISSN
2013 Impact Factor: 2.692
2013 SCImago Journal Rankings: 1.177
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science of China/Research Grants Council (No. 30518001; HKU720/05) Grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (co-PI); The University of Hong Kong: Tai Hing Lam (co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Bernard MY Cheung, Shahrad Taheri, Paramjit Gill, Greg YH Lip, Kar Keung Cheng, G Neil Thomas (co-PI).

References

 

Author Affiliations
  1. The University of Hong Kong
  2. Guangzhou No. 12 Hospital
  3. University of Birmingham
DC FieldValueLanguage
dc.contributor.authorXu, Len_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorYue, XJen_HK
dc.contributor.authorLin, JMen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorLiu, Ben_HK
dc.contributor.authorLi Jin, Yen_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorThomas, GNen_HK
dc.date.accessioned2011-10-28T02:51:45Z-
dc.date.available2011-10-28T02:51:45Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Human Hypertension, 2011, v. 25 n. 3, p. 152-158en_HK
dc.identifier.issn0950-9240en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142573-
dc.description.abstractBrachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, is an established cardiovascular risk factor of ventricular stiffening. We studied the association of baPWV with left-ventricular (LV) diastolic function in a sub-study of the Guangzhou Biobank Cohort Study. In all, 378 Chinese subjects with a normal ejection fraction (50%) had baPWV measurement by a noninvasive automatic waveform analyser, carotid intima-medial thickness (IMT) measurement by B-mode ultrasonography and cardiac diastolic function assessment by echocardiography. After adjusting for age, both baPWV and IMT were associated with LV mass index, posterior wall end-diastolic thickness and inter-ventricular end-diastolic thickness, but only baPWV was associated with deceleration time, atrial flow velocity and E/A ratio. Multivariable linear regression model showed that baPWV and mean arterial pressure, but not IMT, were significantly associated with E/A ratio (Β=-0.02, P=0.03 and Β=-0.36, P=0.02, respectively). The receiver operator characteristic curve showed that baPWV was better than pulse pressure or mean arterial pressure to detect LV diastolic dysfunction (E/A<1.0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction. © 2011 Macmillan Publishers Limited All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhhen_HK
dc.relation.ispartofJournal of Human Hypertensionen_HK
dc.subjectarterial stiffnessen_HK
dc.subjectbrachial-ankle pulse wave velocityen_HK
dc.subjectdiastolic dysfunctionen_HK
dc.subject.meshAnkle Brachial Index-
dc.subject.meshCarotid Artery Diseases - epidemiology - physiopathology - ultrasonography-
dc.subject.meshHeart Ventricles - physiopathology-
dc.subject.meshHypertension - epidemiology - physiopathology - ultrasonography-
dc.subject.meshVascular Resistance - physiology-
dc.titleArterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVDen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/jhh.2010.44en_HK
dc.identifier.pmid20428193en_HK
dc.identifier.scopuseid_2-s2.0-79951682810en_HK
dc.identifier.hkuros184528en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951682810&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue3en_HK
dc.identifier.spage152en_HK
dc.identifier.epage158en_HK
dc.identifier.isiWOS:000287195400003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXu, L=7404744449en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridYue, XJ=35410971600en_HK
dc.identifier.scopusauthoridLin, JM=35409737900en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridLiu, B=36079151900en_HK
dc.identifier.scopusauthoridLi Jin, Y=35932230900en_HK
dc.identifier.scopusauthoridZhang, WS=24464616400en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.citeulike7114758-

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