File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Arterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD
  • Basic View
  • Metadata View
  • XML View
TitleArterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD
 
AuthorsXu, L1 2
Jiang, CQ2
Lam, TH1
Yue, XJ2
Lin, JM2
Cheng, KK3
Liu, B2
Li Jin, Y2
Zhang, WS2
Thomas, GN3
 
Keywordsarterial stiffness
brachial-ankle pulse wave velocity
diastolic dysfunction
 
Issue Date2011
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
CitationJournal Of Human Hypertension, 2011, v. 25 n. 3, p. 152-158 [How to Cite?]
DOI: http://dx.doi.org/10.1038/jhh.2010.44
 
AbstractBrachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, is an established cardiovascular risk factor of ventricular stiffening. We studied the association of baPWV with left-ventricular (LV) diastolic function in a sub-study of the Guangzhou Biobank Cohort Study. In all, 378 Chinese subjects with a normal ejection fraction (50%) had baPWV measurement by a noninvasive automatic waveform analyser, carotid intima-medial thickness (IMT) measurement by B-mode ultrasonography and cardiac diastolic function assessment by echocardiography. After adjusting for age, both baPWV and IMT were associated with LV mass index, posterior wall end-diastolic thickness and inter-ventricular end-diastolic thickness, but only baPWV was associated with deceleration time, atrial flow velocity and E/A ratio. Multivariable linear regression model showed that baPWV and mean arterial pressure, but not IMT, were significantly associated with E/A ratio (Β=-0.02, P=0.03 and Β=-0.36, P=0.02, respectively). The receiver operator characteristic curve showed that baPWV was better than pulse pressure or mean arterial pressure to detect LV diastolic dysfunction (E/A<1.0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction. © 2011 Macmillan Publishers Limited All rights reserved.
 
ISSN0950-9240
2012 Impact Factor: 2.818
2012 SCImago Journal Rankings: 0.898
 
DOIhttp://dx.doi.org/10.1038/jhh.2010.44
 
ISI Accession Number IDWOS:000287195400003
Funding AgencyGrant Number
National Natural Science of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science of China/Research Grants Council (No. 30518001; HKU720/05) Grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (co-PI); The University of Hong Kong: Tai Hing Lam (co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Bernard MY Cheung, Shahrad Taheri, Paramjit Gill, Greg YH Lip, Kar Keung Cheng, G Neil Thomas (co-PI).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorXu, L
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorLam, TH
 
dc.contributor.authorYue, XJ
 
dc.contributor.authorLin, JM
 
dc.contributor.authorCheng, KK
 
dc.contributor.authorLiu, B
 
dc.contributor.authorLi Jin, Y
 
dc.contributor.authorZhang, WS
 
dc.contributor.authorThomas, GN
 
dc.date.accessioned2011-10-28T02:51:45Z
 
dc.date.available2011-10-28T02:51:45Z
 
dc.date.issued2011
 
dc.description.abstractBrachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, is an established cardiovascular risk factor of ventricular stiffening. We studied the association of baPWV with left-ventricular (LV) diastolic function in a sub-study of the Guangzhou Biobank Cohort Study. In all, 378 Chinese subjects with a normal ejection fraction (50%) had baPWV measurement by a noninvasive automatic waveform analyser, carotid intima-medial thickness (IMT) measurement by B-mode ultrasonography and cardiac diastolic function assessment by echocardiography. After adjusting for age, both baPWV and IMT were associated with LV mass index, posterior wall end-diastolic thickness and inter-ventricular end-diastolic thickness, but only baPWV was associated with deceleration time, atrial flow velocity and E/A ratio. Multivariable linear regression model showed that baPWV and mean arterial pressure, but not IMT, were significantly associated with E/A ratio (Β=-0.02, P=0.03 and Β=-0.36, P=0.02, respectively). The receiver operator characteristic curve showed that baPWV was better than pulse pressure or mean arterial pressure to detect LV diastolic dysfunction (E/A<1.0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction. © 2011 Macmillan Publishers Limited All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Human Hypertension, 2011, v. 25 n. 3, p. 152-158 [How to Cite?]
DOI: http://dx.doi.org/10.1038/jhh.2010.44
 
dc.identifier.citeulike7114758
 
dc.identifier.doihttp://dx.doi.org/10.1038/jhh.2010.44
 
dc.identifier.epage158
 
dc.identifier.hkuros184528
 
dc.identifier.isiWOS:000287195400003
Funding AgencyGrant Number
National Natural Science of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science of China/Research Grants Council (No. 30518001; HKU720/05) Grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Cohort Study-Cardiovascular Disease Subcohort (GBCS-CVD) investigators include Guangzhou No. 12 Hospital: Jie Ming Lin, Bin Liu, Xiao Jun Yue, Chao Qiang Jiang (co-PI); The University of Hong Kong: Tai Hing Lam (co-PI); The Chinese University of Hong Kong: Brian Tomlinson, Ka Sing Wong; The University of Birmingham: Bernard MY Cheung, Shahrad Taheri, Paramjit Gill, Greg YH Lip, Kar Keung Cheng, G Neil Thomas (co-PI).

 
dc.identifier.issn0950-9240
2012 Impact Factor: 2.818
2012 SCImago Journal Rankings: 0.898
 
dc.identifier.issue3
 
dc.identifier.pmid20428193
 
dc.identifier.scopuseid_2-s2.0-79951682810
 
dc.identifier.spage152
 
dc.identifier.urihttp://hdl.handle.net/10722/142573
 
dc.identifier.volume25
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Human Hypertension
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnkle Brachial Index
 
dc.subject.meshCarotid Artery Diseases - epidemiology - physiopathology - ultrasonography
 
dc.subject.meshHeart Ventricles - physiopathology
 
dc.subject.meshHypertension - epidemiology - physiopathology - ultrasonography
 
dc.subject.meshVascular Resistance - physiology
 
dc.subjectarterial stiffness
 
dc.subjectbrachial-ankle pulse wave velocity
 
dc.subjectdiastolic dysfunction
 
dc.titleArterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Xu, L</contributor.author>
<contributor.author>Jiang, CQ</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Yue, XJ</contributor.author>
<contributor.author>Lin, JM</contributor.author>
<contributor.author>Cheng, KK</contributor.author>
<contributor.author>Liu, B</contributor.author>
<contributor.author>Li Jin, Y</contributor.author>
<contributor.author>Zhang, WS</contributor.author>
<contributor.author>Thomas, GN</contributor.author>
<date.accessioned>2011-10-28T02:51:45Z</date.accessioned>
<date.available>2011-10-28T02:51:45Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Journal Of Human Hypertension, 2011, v. 25 n. 3, p. 152-158</identifier.citation>
<identifier.issn>0950-9240</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/142573</identifier.uri>
<description.abstract>Brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, is an established cardiovascular risk factor of ventricular stiffening. We studied the association of baPWV with left-ventricular (LV) diastolic function in a sub-study of the Guangzhou Biobank Cohort Study. In all, 378 Chinese subjects with a normal ejection fraction (50%) had baPWV measurement by a noninvasive automatic waveform analyser, carotid intima-medial thickness (IMT) measurement by B-mode ultrasonography and cardiac diastolic function assessment by echocardiography. After adjusting for age, both baPWV and IMT were associated with LV mass index, posterior wall end-diastolic thickness and inter-ventricular end-diastolic thickness, but only baPWV was associated with deceleration time, atrial flow velocity and E/A ratio. Multivariable linear regression model showed that baPWV and mean arterial pressure, but not IMT, were significantly associated with E/A ratio (&#914;=-0.02, P=0.03 and &#914;=-0.36, P=0.02, respectively). The receiver operator characteristic curve showed that baPWV was better than pulse pressure or mean arterial pressure to detect LV diastolic dysfunction (E/A&lt;1.0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction. &#169; 2011 Macmillan Publishers Limited All rights reserved.</description.abstract>
<language>eng</language>
<publisher>Nature Publishing Group. The Journal&apos;s web site is located at http://www.nature.com/jhh</publisher>
<relation.ispartof>Journal of Human Hypertension</relation.ispartof>
<subject>arterial stiffness</subject>
<subject>brachial-ankle pulse wave velocity</subject>
<subject>diastolic dysfunction</subject>
<subject.mesh>Ankle Brachial Index</subject.mesh>
<subject.mesh>Carotid Artery Diseases - epidemiology - physiopathology - ultrasonography</subject.mesh>
<subject.mesh>Heart Ventricles - physiopathology</subject.mesh>
<subject.mesh>Hypertension - epidemiology - physiopathology - ultrasonography</subject.mesh>
<subject.mesh>Vascular Resistance - physiology</subject.mesh>
<title>Arterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1038/jhh.2010.44</identifier.doi>
<identifier.pmid>20428193</identifier.pmid>
<identifier.scopus>eid_2-s2.0-79951682810</identifier.scopus>
<identifier.hkuros>184528</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-79951682810&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>25</identifier.volume>
<identifier.issue>3</identifier.issue>
<identifier.spage>152</identifier.spage>
<identifier.epage>158</identifier.epage>
<identifier.isi>WOS:000287195400003</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
<identifier.citeulike>7114758</identifier.citeulike>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Guangzhou No. 12 Hospital
  3. University of Birmingham