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Article: Aortic arch calcification and vascular disease: The guangzhou biobank cohort study
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TitleAortic arch calcification and vascular disease: The guangzhou biobank cohort study
 
AuthorsXu, L1 3
Jiang, CQ3
Lam, TH1
Thomas, GN2
Zhang, WS3
Cheng, KK2
 
KeywordsAortic arch calcification
Ischemic heart disease
Stroke
Vascular disease
 
Issue Date2011
 
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CRD
 
CitationCardiology, 2011, v. 117 n. 4, p. 260-264 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000323285
 
AbstractObjective: To examine the association between aortic arch calcification (AAC) and vascular disease in an older Chinese sample. Methods: For this study, 30,203 Chinese aged 50-85 years were recruited with baseline information on socioeconomic position, lifestyle and vascular risk factors. The presence and severity of AAC were diagnosed independently from chest X-ray by two radiologists. Results: The age-adjusted prevalence of AAC was significantly higher in women than men [34.6% (95% CI 33.9-35.3) vs. 27.9% (95% CI 26.8-28.8), p < 0.001]. Severity of AAC was significantly associated with physician-diagnosed ischemic heart disease (adjusted OR = 1.55, 95% CI 1.35-1.79) and combined vascular disease (OR = 1.48, 95% CI 1.30-1.69) after adjusting for multiple potential confounders. Increasing severity of AAC was associated with increased risk for ischemic heart disease and vascular disease (p for trend = 0.02 to <0.001). No association between AAC and stroke was found. Conclusions: AAC was strongly and independently associated with vascular disease, suggesting that assessment of AAC from chest X-ray, which is noninvasive and relatively inexpensive, can provide useful information for risk stratification of vascular disease, and should be routinely incorporated in chest X-ray examination. Copyright © 2011 S. Karger AG, Basel.
 
ISSN0008-6312
2013 Impact Factor: 2.044
 
DOIhttp://dx.doi.org/10.1159/000323285
 
ISI Accession Number IDWOS:000288876300004
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study was funded by The University of Hong Kong Foundation for Educational Development and Research, Hong Kong, the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China, and the University of Birmingham, UK. The Guangzhou Biobank Cohort Study investigators include: X.Q. Lao, W.S. Zhang, M. Cao, T. Zhu, B. Liu, C.Q. Jiang (co-principal investigator; all from the Guangzhou No. 12 Hospital); C.M. Schooling, S.M. McGhee, R. Fielding, G.M. Leung, T.H. Lam (co-principal investigator; all from the University of Hong Kong); P. Adab, G.N. Thomas, K.K. Cheng (co-principal investigator; all from the University of Birmingham).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorXu, L
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorLam, TH
 
dc.contributor.authorThomas, GN
 
dc.contributor.authorZhang, WS
 
dc.contributor.authorCheng, KK
 
dc.date.accessioned2011-10-28T02:51:39Z
 
dc.date.available2011-10-28T02:51:39Z
 
dc.date.issued2011
 
dc.description.abstractObjective: To examine the association between aortic arch calcification (AAC) and vascular disease in an older Chinese sample. Methods: For this study, 30,203 Chinese aged 50-85 years were recruited with baseline information on socioeconomic position, lifestyle and vascular risk factors. The presence and severity of AAC were diagnosed independently from chest X-ray by two radiologists. Results: The age-adjusted prevalence of AAC was significantly higher in women than men [34.6% (95% CI 33.9-35.3) vs. 27.9% (95% CI 26.8-28.8), p < 0.001]. Severity of AAC was significantly associated with physician-diagnosed ischemic heart disease (adjusted OR = 1.55, 95% CI 1.35-1.79) and combined vascular disease (OR = 1.48, 95% CI 1.30-1.69) after adjusting for multiple potential confounders. Increasing severity of AAC was associated with increased risk for ischemic heart disease and vascular disease (p for trend = 0.02 to <0.001). No association between AAC and stroke was found. Conclusions: AAC was strongly and independently associated with vascular disease, suggesting that assessment of AAC from chest X-ray, which is noninvasive and relatively inexpensive, can provide useful information for risk stratification of vascular disease, and should be routinely incorporated in chest X-ray examination. Copyright © 2011 S. Karger AG, Basel.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationCardiology, 2011, v. 117 n. 4, p. 260-264 [How to Cite?]
DOI: http://dx.doi.org/10.1159/000323285
 
dc.identifier.doihttp://dx.doi.org/10.1159/000323285
 
dc.identifier.epage264
 
dc.identifier.hkuros184186
 
dc.identifier.isiWOS:000288876300004
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study was funded by The University of Hong Kong Foundation for Educational Development and Research, Hong Kong, the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China, and the University of Birmingham, UK. The Guangzhou Biobank Cohort Study investigators include: X.Q. Lao, W.S. Zhang, M. Cao, T. Zhu, B. Liu, C.Q. Jiang (co-principal investigator; all from the Guangzhou No. 12 Hospital); C.M. Schooling, S.M. McGhee, R. Fielding, G.M. Leung, T.H. Lam (co-principal investigator; all from the University of Hong Kong); P. Adab, G.N. Thomas, K.K. Cheng (co-principal investigator; all from the University of Birmingham).

 
dc.identifier.issn0008-6312
2013 Impact Factor: 2.044
 
dc.identifier.issue4
 
dc.identifier.pmid21252535
 
dc.identifier.scopuseid_2-s2.0-78651528078
 
dc.identifier.spage260
 
dc.identifier.urihttp://hdl.handle.net/10722/142563
 
dc.identifier.volume117
 
dc.languageeng
 
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CRD
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofCardiology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCardiology. Copyright © S Karger AG.
 
dc.subject.meshAorta, Thoracic
 
dc.subject.meshAortic Diseases
 
dc.subject.meshCalcinosis
 
dc.subject.meshRisk Factors
 
dc.subject.meshSeverity of Illness Index
 
dc.subjectAortic arch calcification
 
dc.subjectIschemic heart disease
 
dc.subjectStroke
 
dc.subjectVascular disease
 
dc.titleAortic arch calcification and vascular disease: The guangzhou biobank cohort study
 
dc.typeArticle
 
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<contributor.author>Jiang, CQ</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Thomas, GN</contributor.author>
<contributor.author>Zhang, WS</contributor.author>
<contributor.author>Cheng, KK</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Guangzhou No. 12 Hospital