File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: A prospective study

TitlePrediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: A prospective study
Authors
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com
Citation
Annals Of Surgery, 2011, v. 254 n. 4, p. 569-576 How to Cite?
AbstractOBJECTIVE: To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy. BACKGROUND: HCC recurrence frequently occurs within the first year after hepatectomy, probably due to circulating tumor cells that have been shed from the primary tumor before hepatectomy. Because CSCs are more likely to initiate tumor growth than mature cancer cells, a high level of circulating CSCs may be a hint for HCC recurrence. METHODS: Multicolor flow cytometry was used to detect the number of circulating CSCs (CD45 -CD90 +CD44 +) in the peripheral circulation of 82 HCC patients 1 day before hepatectomy. The patients were monitored by CT or MRI for recurrence every 3 months. RESULTS: Forty-one (50%) patients had recurrence after a median follow-up period of 13.2 months (range, 1.3-57.1 months). Patients with recurrence had a higher median level of circulating CSCs than patients without recurrence (0.02% vs. 0.01%; P < 0.0001). Circulating CSCs > 0.01% predicted intrahepatic recurrence (relative risk 3.54; 95% CI, 1.41-8.88; P = 0.007) and extrahepatic recurrence (relative risk 10.15; 95% CI, 3-34.4; P = 0.0002). Patients with >0.01% circulating CSCs had a lower 2-year recurrence-free survival rate (22.7% vs. 64.2%; P < 0.0001) and overall survival rate (58.5% vs. 94.1%; P = 0.0005) than patients with ≤0.01% circulating CSCs. On multivariable analysis, circulating CSCs > 0.01%, tumor stage and tumor size were independent factors predicting recurrence-free survival. CONCLUSIONS: Circulating CSCs predicted posthepatectomy HCC recurrence with high accuracy. They may be the target of eradication in the prevention of posthepatectomy HCC metastasis and recurrence. Copyright © 2011 by Lippincott Williams & Wilkins.
DescriptionPapers of the 131st ASA annual meeting
Persistent Identifierhttp://hdl.handle.net/10722/142543
ISSN
2014 Impact Factor: 8.327
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong, Hong Kong, China
Funding Information:

Supported by Mrs. Li Ka Shing Fund, The University of Hong Kong, Hong Kong, China.

References

 

DC FieldValueLanguage
dc.contributor.authorFan, STen_HK
dc.contributor.authorYang, ZFen_HK
dc.contributor.authorHo, DWYen_HK
dc.contributor.authorNg, MNPen_HK
dc.contributor.authorYu, WCen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2011-10-28T02:50:56Z-
dc.date.available2011-10-28T02:50:56Z-
dc.date.issued2011en_HK
dc.identifier.citationAnnals Of Surgery, 2011, v. 254 n. 4, p. 569-576en_HK
dc.identifier.issn0003-4932en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142543-
dc.descriptionPapers of the 131st ASA annual meeting-
dc.description.abstractOBJECTIVE: To investigate whether circulating cancer stem cells (CSCs) of hepatocellular carcinoma (HCC) can predict its recurrence after hepatectomy. BACKGROUND: HCC recurrence frequently occurs within the first year after hepatectomy, probably due to circulating tumor cells that have been shed from the primary tumor before hepatectomy. Because CSCs are more likely to initiate tumor growth than mature cancer cells, a high level of circulating CSCs may be a hint for HCC recurrence. METHODS: Multicolor flow cytometry was used to detect the number of circulating CSCs (CD45 -CD90 +CD44 +) in the peripheral circulation of 82 HCC patients 1 day before hepatectomy. The patients were monitored by CT or MRI for recurrence every 3 months. RESULTS: Forty-one (50%) patients had recurrence after a median follow-up period of 13.2 months (range, 1.3-57.1 months). Patients with recurrence had a higher median level of circulating CSCs than patients without recurrence (0.02% vs. 0.01%; P < 0.0001). Circulating CSCs > 0.01% predicted intrahepatic recurrence (relative risk 3.54; 95% CI, 1.41-8.88; P = 0.007) and extrahepatic recurrence (relative risk 10.15; 95% CI, 3-34.4; P = 0.0002). Patients with >0.01% circulating CSCs had a lower 2-year recurrence-free survival rate (22.7% vs. 64.2%; P < 0.0001) and overall survival rate (58.5% vs. 94.1%; P = 0.0005) than patients with ≤0.01% circulating CSCs. On multivariable analysis, circulating CSCs > 0.01%, tumor stage and tumor size were independent factors predicting recurrence-free survival. CONCLUSIONS: Circulating CSCs predicted posthepatectomy HCC recurrence with high accuracy. They may be the target of eradication in the prevention of posthepatectomy HCC metastasis and recurrence. Copyright © 2011 by Lippincott Williams & Wilkins.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.comen_HK
dc.relation.ispartofAnnals of Surgeryen_HK
dc.subject.meshCarcinoma, Hepatocellular - blood - surgery-
dc.subject.meshHepatectomy-
dc.subject.meshLiver Neoplasms - blood - surgery-
dc.subject.meshNeoplasm Recurrence, Local - blood - epidemiology-
dc.subject.meshNeoplastic Stem Cells-
dc.titlePrediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: A prospective studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-4932&volume=254&issue=4&spage=569&epage=576&date=2011&atitle=Prediction+of+posthepatectomy+recurrence+of+hepatocellular+carcinoma+by+circulating+cancer+stem+cells:+a+prospective+studyen_US
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/SLA.0b013e3182300a1den_HK
dc.identifier.pmid21892074en_HK
dc.identifier.scopuseid_2-s2.0-80053284820en_HK
dc.identifier.hkuros196688en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053284820&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume254en_HK
dc.identifier.issue4en_HK
dc.identifier.spage569en_HK
dc.identifier.epage576en_HK
dc.identifier.isiWOS:000295162400004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.f100014257962-
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridYang, ZF=39863860200en_HK
dc.identifier.scopusauthoridHo, DWY=7402971906en_HK
dc.identifier.scopusauthoridNg, MNP=23478329500en_HK
dc.identifier.scopusauthoridYu, WC=37022285400en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats