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Article: Effects of cigarette smoking and restraint stress on human colon tumor growth in mice

TitleEffects of cigarette smoking and restraint stress on human colon tumor growth in mice
Authors
KeywordsB-cell lymphoma-2
Cigarette smoking
Colon cancer
Cyclooxygenase-2
Prostaglandin E2
Restraint stress
Issue Date2009
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIG
Citation
Digestion, 2009, v. 80 n. 4, p. 209-214 How to Cite?
AbstractBackground: Cigarette smoking is a risk factor for colon cancer. Studies suggest that stress increases the incidence and promotes the development of cancers. Cigarette smoking and stress are closely associated, as people often smoke under stressful conditions and both of them can activate the adrenergic nervous system. Aims: To investigate the effects of cigarette smoking and restraint stress on colon cancer growth and the possible underlying mechanisms in these pathological processes. Methods: Nude mice bearing a HT-29 human colon cancer xenograft were either exposed to cigarette smoke and/or restraint stress. Cotinine and epinephrine levels in plasma of nude mice were measured by enzyme immunoassays. Expression of cyclooxygenase-2 (COX-2) and B-cell lymphoma-2 (Bcl-2) in tumor tissues were detected by Western blot. Prostaglandin E 2 (PGE2) concentrations were determined by enzyme immunoassay. Results: 4% cigarette smoking together with restraint stress 1 h daily for 33 days promoted tumor growth in nude mice. This was accompanied by the increase of plasma levels of cotinine and epinephrine in these animals. They also enhanced the COX-2, Bcl-2 expressions and PGE2 levels in tumor tissues. Conclusion: These findings are important in understanding the pathogenesis of colon cancer, particularly related to cigarette smoking and stress. © 2009 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/142539
ISSN
2015 Impact Factor: 1.884
2015 SCImago Journal Rankings: 0.953
ISI Accession Number ID
Funding AgencyGrant Number
Chinese University of Hong Kong
Hong Kong Research Grants CouncilCUHK 7499/05M
Funding Information:

The study was supported by the Direct Grant from the Chinese University of Hong Kong and the Hong Kong Research Grants Council (CUHK 7499/05M).

References

 

DC FieldValueLanguage
dc.contributor.authorWong, HPSen_HK
dc.contributor.authorLi, ZJen_HK
dc.contributor.authorShin, VYen_HK
dc.contributor.authorTai, EKKen_HK
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorYu, Len_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2011-10-28T02:50:46Z-
dc.date.available2011-10-28T02:50:46Z-
dc.date.issued2009en_HK
dc.identifier.citationDigestion, 2009, v. 80 n. 4, p. 209-214en_HK
dc.identifier.issn0012-2823en_HK
dc.identifier.urihttp://hdl.handle.net/10722/142539-
dc.description.abstractBackground: Cigarette smoking is a risk factor for colon cancer. Studies suggest that stress increases the incidence and promotes the development of cancers. Cigarette smoking and stress are closely associated, as people often smoke under stressful conditions and both of them can activate the adrenergic nervous system. Aims: To investigate the effects of cigarette smoking and restraint stress on colon cancer growth and the possible underlying mechanisms in these pathological processes. Methods: Nude mice bearing a HT-29 human colon cancer xenograft were either exposed to cigarette smoke and/or restraint stress. Cotinine and epinephrine levels in plasma of nude mice were measured by enzyme immunoassays. Expression of cyclooxygenase-2 (COX-2) and B-cell lymphoma-2 (Bcl-2) in tumor tissues were detected by Western blot. Prostaglandin E 2 (PGE2) concentrations were determined by enzyme immunoassay. Results: 4% cigarette smoking together with restraint stress 1 h daily for 33 days promoted tumor growth in nude mice. This was accompanied by the increase of plasma levels of cotinine and epinephrine in these animals. They also enhanced the COX-2, Bcl-2 expressions and PGE2 levels in tumor tissues. Conclusion: These findings are important in understanding the pathogenesis of colon cancer, particularly related to cigarette smoking and stress. © 2009 S. Karger AG, Basel.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DIGen_HK
dc.relation.ispartofDigestionen_HK
dc.rightsDigestion. Copyright © S Karger AG.en_US
dc.subjectB-cell lymphoma-2en_HK
dc.subjectCigarette smokingen_HK
dc.subjectColon canceren_HK
dc.subjectCyclooxygenase-2en_HK
dc.subjectProstaglandin E2en_HK
dc.subjectRestraint stressen_HK
dc.subject.meshAdenocarcinoma - etiology - metabolism - psychology-
dc.subject.meshColonic Neoplasms - etiology - metabolism - psychology-
dc.subject.meshProto-Oncogene Proteins c-bcl-2 - metabolism-
dc.subject.meshSmoking - adverse effects-
dc.subject.meshStress, Psychological - complications-
dc.titleEffects of cigarette smoking and restraint stress on human colon tumor growth in miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-2823&volume=80&issue=4&spage=209&epage=214&date=2009&atitle=Effects+of+cigarette+smoking+and+restraint+stress+on+human+colon+tumor+growth+in+miceen_US
dc.identifier.emailWong, HPS:hpswong@hkusua.hku.hken_HK
dc.identifier.authorityWong, HPS=rp00808en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000231898en_HK
dc.identifier.pmid19776585-
dc.identifier.scopuseid_2-s2.0-70349264308en_HK
dc.identifier.hkuros184629en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349264308&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue4en_HK
dc.identifier.spage209en_HK
dc.identifier.epage214en_HK
dc.identifier.isiWOS:000272603800001-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridWong, HPS=8644138100en_HK
dc.identifier.scopusauthoridLi, ZJ=35170171500en_HK
dc.identifier.scopusauthoridShin, VY=7003491170en_HK
dc.identifier.scopusauthoridTai, EKK=9842278900en_HK
dc.identifier.scopusauthoridWu, WKK=18345422600en_HK
dc.identifier.scopusauthoridYu, L=16314581700en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK

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